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Asstated intheStrategy for American Leadership in Advanced Manufacturing,worldwide competition in Manufacturing has been dominated in recent decades by the maturation, commoditization, and widespread application of computation in production equipment and logistics, effectively leveling the global technological playing field and putting a premium on low wages and incremental technical improvements.[1] The next generation of technological competition in Manufacturing will be dictated by inventions of new materials, chemicals, devices, systems, processes, machines, design and work methods, social structures and business practices. Fundamental research will be required in robotics, artificial intelligence, biotechnology, materials science, sustainability, education and public policy, and workforce development to take the lead in this global competition. The research supported under this solicitationwillenhance U.S. leadership in Manufacturing far into the future by providing new capabilitiesfor established companies andentrepreneurs,improving ourhealth and quality of life,andreducingthe impact of Manufacturing industries on the environment.

The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society.  The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors.  A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials.  Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding

The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society.  The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors.  A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials.  Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding

The goal of the Combustion and Fire Systems program is to generate cleaner global and local environments, enhance public safety, improve energy and homeland security, and enable more efficient energy conversion and manufacturing.  The program endeavors to create fundamental scientific knowledge and engineering solutions that are needed to develop useful combustion applications and for mitigating the effects of fire.  The program aims to identify and understand the controlling basic principles and use that knowledge to create predictive capabilities for designing and optimizing practical combustion devices. Additional outcomes of interest for this program include: broad-based tools - experimental, theoretical, and computational - which can be applied to a variety of problems in combustion and fire systems; science and technology for clean and efficient generation of power, both stationary and mobile; combustion science and technology for energy-efficient manufacturing; research that enables clean global and local environments (reduction in combustion generated pollutants); enhanced public safety and homeland security through research on fire growth, inhibition and suppression; and education and training of an innovative workforce for power, transportation, and manufacturing industries.

The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society.  The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors.  A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials.  Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding.

The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society.  The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors.  A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials.  Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding.

The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society.  The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors.  A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials.  Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding

The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics (PRM) program is to advance fundamental engineering research on the rates and mechanisms of important classes of catalyzed and uncatalyzed chemical reactions as they relate to the design, production, and application of catalysts, chemical processes, biochemical processes, and specialized materials that have important impacts on society.  The program seeks to advance electrochemical and photochemical processes of engineering significance or with commercial potential, design and optimization of complex chemical and biochemical processes, thermodynamic modeling and experiments that relate molecular dynamics to macroscopic properties and behavior, dynamic modeling and control of process systems and individual process units, reactive processing of polymers/ceramics/thin films, and interactions between chemical reactions and transport processes in reactive systems, for the integration of this information into the design of complex chemical and biochemical reactors.  A substantial focus of the PRM program is to impact the chemical manufacturing enterprise by funding projects aimed at zero emissions and environmentally-friendly, smart manufacturing using sustainable materials.  Areas that focus on reactors of all types (fuel cells, batteries, microreactors, biochemical reactors, etc.), reactor design in general, and design and control of all systems associated with energy from renewable sources have a high priority for funding

This Funding Opportunity Announcement (FOA) is soliciting applications to develop Solid Oxide Fuel Cell Technology in order to support fuel cells system manufacturers in addressing issues related to cost and reliability of fuel cells systems. Applications are sought in two areas of interest (AOI) that include AOI 1 - Solid Oxide Fuel Cells (SOFC) Core Technology Research and AOI 2 - Core Technology Research and Development (R&D) in Support of Near-Term SOFC Power Systems Prototype Tests. AOI 1 is supporting transformational technologies that are focused on early-stage laboratory-scale R&D. Successful projects will result in validation of concepts at a laboratory-scale. Collaboration with a fuel cell system manufacturer is encouraged. AOI 2 will seek projects that address reliability issues facing 2nd Generation SOFC power systems in an operational environment. This AOI will require a team approach where the participation of at least one fuel cell system manufacturer as a prime or a sub-recipient in the team is required. Teams should be able to take the technology developed during the award to the point that it can be validated in an operational system. Fuel cell technology other than SOFC will be considered non-responsive to both AOIs.

This Program encourages research on processes and production systems based on computation, modeling and simulation, use of process metrology, sensing, monitoring, and control, and assessment of product (nanomaterial, nanostructure, nanodevice or nanosystem) quality and performance. The Program seeks to explore transformative approaches to nanomanufacturing, including but not limited to: micro-reactor and micro-fluidics enabled nanosynthesis, bio-inspired nanomanufacturing, manufacturing by nanomachines, additive nanomanufacturing, hierarchical nanostructure assembly, continuous high-rate nanofabrication such as roll-to-roll processing or massively-parallel large-area processing, and modular manufacturing platforms for nanosystems. 

The National Institute on Drug Abuse (NIDA) intends to solicit proposals from offerors having the capability to perform the following tasks: (1) cultivate and harvest, process, analyze, store, and distribute cannabis (marijuana) for research, (2) extract cannabis to produce pure and standardized (current Good Manufacturing Practices (cGMP)-grade) cannabis extracts containing varying concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), (3) isolate cGMP and research grade THC, CBD, and other cannabinoids, (4) periodically analyze cannabis extracts, and isolated cannabinoids for authenticity, purity and stability, (5) develop new methods for growing cannabis plants containing high THC, low CBD; high CBD, low THC; and equal strength of CBD and THC, (6) manufacture, analyze, determine stability, store, and supply marijuana cigarettes, and (7) supply cannabis, cannabis extract, other phyto-cannabinoids, and marijuana cigarettes to research investigators and/or to the NIDA Drug Supply program upon NIDA authorization.

NineSigma, representing a global electric motor manufacturer, invites proposals for a durable, high-temperature non-conductive coating for steel. In the manufacture of electric motors, NineSigma's client makes a rotor that consists of a stack of thin, die-stamped steel sheets with a die-cast aluminum squirrel cage.  It is important that the steel be electrically isolated from the aluminum.  NineSigma's client needs a durable non-conductive coating to apply to the steel assembly prior to die-casting the aluminum.  The coating must withstand temperatures associated with the die-casting process and with subsequent thermal cycling.

The Confluence Tech Showcase will connect vendors, manufacturers, developers, entrepreneurs, technologists, engineers, and students to our regional utilities to share solutions to the top challenges that have been identified by the utilities. This call for abstracts is addressed to vendors, manufacturers, developers, researchers, technologists, engineers, utilities, entrepreneurs, students and anyone with a solution to the challenges outlined by the Regional Utility Network.   Topics: (Sessions have been categorized into the following tracks: financial innovations, operational efficiencies, business drivers, resiliency opportunities, regulatory concerns, and water sector challenges for utilities within the water cycle (stormwater, drinking water, wastewater).  Abstracts should provide a technology, process, and/or case study of solutions related to these topics, and clearly indicate their value proposition and unique aspects in addressing the problem.  )

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates.  The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems.  Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability.  Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.  Proposals whose main focus is on the synthesis of particles are not encouraged.

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates.  The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems.  Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability.  Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.  Proposals whose main focus is on the synthesis of particles are not encouraged.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program.

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates.  The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems.  Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability.  Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.

The goal of the Particulate and Multiphase Processes (PMP) program is to support fundamental research on physico-chemical phenomena that govern particulate and multiphase systems, including flow of suspensions, drops and bubbles, granular and granular-fluid flows, behavior of micro- and nanostructured fluids, and self-assembly/directed-assembly processes that involve particulates.  The program encourages transformative research to improve our basic understanding of particulate and multiphase processes with emphasis on research that demonstrates how particle-scale phenomena affect the behavior and dynamics of larger-scale systems.  Although proposed research should focus on fundamentals, a clear vision is required that anticipates how results could benefit important applications in advanced manufacturing, energy harvesting, transport in biological systems, biotechnology, or environmental sustainability.  Collaborative and interdisciplinary proposals are encouraged, especially those that involve a combination of experiment with theory or modeling.

The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications focusing on integrated, transdisciplinary research that would advance scientific understanding of potential for impacts to ecosystem wellbeing associated with the use of manufactured chemicals. Specifically, the RFA would solicit proposals for systems-based research to develop and apply innovative metrics and modeling approaches to improve evaluation of ecological resilience and impact analyses, and to support environmental sustainability. Successful proposals will translate emerging and advanced methods, data, and computational tools to address complexity of these systems and distill drivers of adverse outcomes to ecological organisms and populations.

The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications focusing on integrated, transdisciplinary research that would advance scientific understanding of potential for impacts to ecosystem wellbeing associated with the use of manufactured chemicals. Specifically, the RFA would solicit proposals for systems-based research to develop and apply innovative metrics and modeling approaches to improve evaluation of ecological resilience and impact analyses, and to support environmental sustainability. Successful proposals will translate emerging and advanced methods, data, and computational tools to address complexity of these systems and distill drivers of adverse outcomes to ecological organisms and populations.

This Research Announcement (RA) solicits ground-breaking single-investigator proposals from junior faculty for research and development in the areas of physical sciences, engineering, materials, mathematics, biology, computing, informatics, and manufacturing of interest to DARPA's Biological Technologies Office (BTO), Defense Sciences Office (DSO) and Microsystems Technology Office (MTO).

This Research Announcement (RA) solicits ground-breaking single-investigator proposals from junior faculty for research and development in the areas of physical sciences, engineering, materials, mathematics, biology, computing, informatics, and manufacturing of interest to DARPA's Biological Technologies Office (BTO), Defense Sciences Office (DSO) and Microsystems Technology Office (MTO).

In recent years, somatic cells as therapeutic agents have provided new treatment approaches for a number of pathological conditions that were deemed untreatable, or difficult to treat. Several successful cell therapies using T cells have been demonstrated for cancer and autoimmune diseases, while stem cell therapies have given relief for heart disease and stroke. Hundreds of clinical trials are ongoing to examine efficacy of cell therapies for a variety of other diseases including diabetes, Alzheimer's, Parkinson's, and Crohn's disease. Production of therapeutic cells is currently expensive and, therefore, cost prohibitive for the large number of people who might benefit from these treatments. The overarching goal of this Advanced Biomanufacturing of Therapeutic Cells (ABTC) solicitation is to catalyze well-integrated interdisciplinary research to understand, design, and control cell manufacturing systems and processes that will enable reproducible, cost-effective, and high-quality production of cells with predictable performance for the identified therapeutic function.

In recent years, somatic cells as therapeutic agents have provided new treatment approaches for a number of pathological conditions that were deemed untreatable, or difficult to treat. Several successful cell therapies using T cells have been demonstrated for cancer and autoimmune diseases, while stem cell therapies have given relief for heart disease and stroke. Hundreds of clinical trials are ongoing to examine efficacy of cell therapies for a variety of other diseases including diabetes, Alzheimer's, Parkinson's, and Crohn's disease. Production of therapeutic cells is currently expensive and, therefore, cost prohibitive for the large number of people who might benefit from these treatments. The overarching goal of this Advanced Biomanufacturing of Therapeutic Cells (ABTC) solicitation is to catalyze well-integrated interdisciplinary research to understand, design, and control cell manufacturing systems and processes that will enable reproducible, cost-effective, and high-quality production of cells with predictable performance for the identified therapeutic function.

The goal of the Combustion and Fire Systems program is to generate cleaner global and local environments, enhance public safety, improve energy and homeland security, and enable more efficient energy conversion and manufacturing. 

The Small Business Innovation Research (SBIR) Program stimulates technological innovation in the private sector by strengthening the role of small business concerns in meeting Federal research and development needs, increasing the commercial application of federally supported research results, and fostering and encouraging participation by socially and economically disadvantaged and women-owned small businesses. The SBIR program solicits proposals from the small business sector consistent with NSF's mission. The program is governed by Public Law 112-81 (SBIR/STTR Reauthorization Act of 2011). A main purpose of the legislation is to stimulate technological innovation and increase private sector commercialization. The NSF SBIR program is therefore in a unique position to meet both the goals of NSF and the purpose of the SBIR legislation by transforming scientific discovery into both social and economic benefit, and by emphasizing private sector commercialization. Accordingly, NSF has formulated broad solicitation topics for SBIR that conform to the high-technology investment sector's interests. The topics are: Biological and Chemical Technologies (BC) Education Applications (EA) Electronics, Information and Communication Technologies (EI) Nanotechnology, Advanced Materials, and Manufacturing (NM)

An objective of the Critical Infrastructure Resilience Institute (CIRI) is to bring together capabilities of colleges, universities, federal laboratories, industry, and nonprofit organizations to assess and improve resilience in the ten critical infrastructures for which the Department of Homeland Security is the designated sector-specific agency: * Chemical * Commercial Facilities * Communications * Critical Manufacturing * Dams * Emergency Services * Government Facilities * Information Technology * Nuclear Reactors, Materials, and Waste * Transportation Systems CIRI activities are organized around four themes: 1. Understanding resilient critical infrastructure systems. 2. Application of critical infrastructure in the real world. 3. The business case for infrastructure resiliency. 4. The future of resiliency. With those objectives in mind, CIRI is seeking proposals for projects that will improve the nation's ability to * Understand vulnerabilities and risks * Quantitatively assess risks and resilience measures * Mitigate risks and improve resilience * Establish the business case for resiliency * Deploy resiliency measures