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This Funding Opportunity Announcement (FOA) intends to support investigators who have interest and capability to join efforts for the discovery of cell-based chemical probes for novel brain targets. It is expected that applicants will have in hand the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds. Through this FOA, NIH wishes to stimulate research in: 1) discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of NIMH, NIA, and/or NIDCD; and 2) discovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms. Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes. The main emphasis of projects submitted under this FOA should be in the discovery of cell-based chemical probes. Applicants interested in developing in vivo chemical probes may wish to apply using the companion R01 mechanism (PAR-17-336).

Awarded through the ACS Division of Medicinal Chemistry, the annual award is intended to recognize two current graduate students and/or postdoctoral researchers who have had a primary, leading role in significant scientific discoveries that enhance the field of medicinal chemistry. The awardees will present an award address at the fall national meeting of the American Chemical Society as a part of Division of Medicinal Chemistry programming, receive a commemorative plaque and honorarium, and receive $500 to partially offset travel expenses to attend the meeting.

The goal of research funded under the interdisciplinary P2C2 solicitation is to utilize key geological, chemical, atmospheric (gas in ice cores), and biological records of climate system variability to provide insights into the mechanisms and rate of change that characterized Earth's past climate variability, the sensitivity of Earth's climate system to changes in forcing, and the response of key components of the Earth system to these changes.

This Funding Opportunity Announcement (FOA) intends to support investigators who have interest and capability to join efforts for the discovery of in vivo chemical probes. It is expected that applicants will have in hand the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds. Through this FOA, NIH wishes to stimulate research in 1) discovery and development of novel, small molecules for their potential use in studying disease treatment relevant to the missions of the participating NIH Institutes, and 2) discovery and/or validation of novel, biological targets that will inform studies of disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease targets and processes.

Miami University researchers can provide input about the professional development opportunities they'd like to see OARS offer in the next year by completing this 5-minute survey.

The purpose of this Request for Information is to seek information from power generation equipment manufacturers, utilities, power plant architect-engineers, and other stakeholders that can be used as input to a Department of Energy Fossil Energy Research and Development program that will culminate in the design, construction, and operation of a coal-based pilot-scale power plant by 2025. The coal-based pilot plant will be used as the basis for scaling up to a commercial offering that is highly efficient (40 percent or greater higher heating value), modular (unit sizes of approximately 50 to 350 MW), and economical for both international and domestic power generation. The pilot plant and commercial offering does not have to capture and store carbon dioxide, but must be carbon capture ready. This is solely a request for information and is not a Funding Opportunity Announcement. U.S. Department of Energy is not accepting applications to this Request for Information.

Request for Information - Upgrading Carbon Derived from Methane Pyrolysis This is a Request for Information (RFI) only. This RFI is not accepting application for financial assistance. The purpose of this RFI is solely to solicit input for ARPA-E consideration to inform the possible formulation of future programs. The Advanced Research Projects Agency -Energy (ARPA-E) in the US Department of Energy is seeking information concerning technologies to produce hydrogen and elemental carbon from the thermal decomposition of methane (also known as methane pyrolysis, methane cracking, or methane splitting). Recognizing that the value of the carbon product would be a key factor in the economic feasibility of such processes, ARPA-E seeks input from experts in the fields of materials science (including advanced carbon fiber synthesis), process engineering, methane pyrolysis, plasma chemistry, and chemical engineering regarding potential mechanisms for the bulk conversion of carbon materials, specifically from less valuable forms (e.g. amorphous carbon) or mixtures, to more valuable single allotropes or controlled mixtures of high-value carbon structures. Consistent with the agency's mission, ARPA-E is seeking insights on clearly disruptive, novel technologies for such conversions, early in the R&D cycle, and not integration strategies for existing technologies. The information you provide may be used by ARPA-E in support of program planning.

The Catalysis program is part of the Chemical Process Systems cluster, which also includes: 1) the Electrochemical Systems program; 2) the Interfacial Engineering program; and 3) the Process Systems, Reaction Engineering, and Molecular Thermodynamics program. The goals of the Catalysis program are to increase fundamental understanding in catalytic engineering science and to advance the development of catalytic materials and reactions that are beneficial to society. Research in this program should focus on new concepts for catalytic materials and reactions, utilizing synthetic, theoretical, and experimental approaches. Target applications include fuels, specialty and bulk chemicals, environmental catalysis, biomass conversion to fuels and chemicals, conversion of greenhouse gases, and generation of solar hydrogen, as well as efficient routes to energy utilization. Heterogeneous catalysis represents the main thrust of the program. Proposals related to both gas-solid and liquid-solid heterogeneous catalysis are welcome, as are proposals that incorporate concepts from homogeneous catalysis. Topic areas that are of particular interest include: · Renewable energy-related catalysis with applications in electrocatalysis, photocatalysis, and catalytic conversion of biomass-derived chemicals. Catalysis aimed at closing the carbon cycle (especially conversion of CO2, methane, and natural gas to fuels and chemical intermediates). · Catalytic alternatives to traditionally non-catalytic reaction processes, as well as new catalyst designs for established catalytic processes. · Environmental catalysis (including energy-efficient and green routes to fuels and chemicals). ·

The Process Systems, Reaction Engineering and Molecular Thermodynamics program is part of the Chemical Process Systems cluster, which also includes: 1) the Catalysis program; 2) the Electrochemical Systems program; and 3) the Interfacial Engineering program. The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics program is to advance fundamental engineering research on the rates and mechanisms of chemical reactions, systems engineering and molecular thermodynamics as they relate to the design and optimization of chemical reactors and the production of specialized materials that have important impacts on society. The program supports the development of advanced optimization and control algorithms for chemical processes, molecular and multi-scale modeling of complex chemical systems, fundamental studies on molecular thermodynamics, and the integration of this information into the design of complex chemical reactors. An important area supported by the program focuses on the development of energy-efficient and environmentally-friendly chemical processes and materials. Proposals should focus on: · Chemical reaction engineering: This area encompasses the interaction of transport phenomena and kinetics in reactive systems and the use of this knowledge in the design of complex chemical reactors. Focus areas include novel reactor designs, such as catalytic and membrane reactors, micro-reactors, and atomic layer deposition systems; studies of reactions in supercritical fluids; novel activation techniques, such as plasmas, acoustics, and microwaves; design of multifunctional systems, such as "chemical-factory/lab-on-a-chip" concepts; and biomass conversion to fuels and chemicals. The program also supports new approaches that enable the design of modular chemical manufacturing systems.

The Critical Aspects of Sustainability (CAS) program includes the Division of Chemistry (CHE) and the Division of Materials Research (DMR) within the Directorate for Mathematical and Physical Sciences (MPS), the Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) and the Division of Civil, Mechanical and Manufacturing Innovation (CMMI) within the Directorate for Engineering (ENG), and the Division of Earth Sciences (EAR) within the Directorate for Geosciences (GEO).

The National Science Foundation (NSF) through its Divisions of Electrical, Communications and Cyber Systems (ECCS); Chemical, Bioengineering, Environmental and Transport Systems (CBET); Civil, Mechanical and Manufacturing Innovation (CMMI); Information and Intelligent Systems (IIS); and Mathematical Sciences (DMS) announces a solicitation on Multimodal Sensor Systems for Precision Health enabled by Data Harnessing, Artificial Intelligence (AI), and Learning. Next-generation multimodal sensor systems for precision health integrated with AI, machine learning (ML), and mathematical and statistical (MS) methods for learning can be envisioned for harnessing a large volume of diverse data in real time with high accuracy, sensitivity and selectivity, and for building predictive models to enable more precise diagnosis and individualized treatments. It is expected that these multimodal sensor systems will have the potential to identify with high confidence combinations of biomarkers, including kinematic and kinetic indicators associated with specific disease and disability. This focused solicitation seeks high-risk/high-return interdisciplinary research on novel concepts, innovative methodologies, theory, algorithms, and enabling technologies that will address the fundamental scientific issues and technological challenges associated with precision health.

The purpose of this Funding Opportunity Announcement (FOA) is to support research projects that examine how inter-organelle communication in cancer cells and/or tumor-associated cells affects cellular function, adaptation, and phenotypic plasticity.

The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) is sponsoring an event (D3) to (1) familiarize attendees with DSO's mission and the nature of the efforts we support; (2) promote understanding of how to do business with DSO and (3) facilitate discussions with potential performers. The event is scheduled for Thursday, June 15, 2017 at the DoubleTree Crystal City (300 Army Navy Drive Arlington, VA 22202); selected sessions will be webcast for those who would like to participate remotely.  Advance registration is required for attending the event in person or for viewing the webcast.

A large amount of the research and development of post-combustion carbon capture technology focuses on three main technologies: adsorption, absorption and membranes. Each of these technologies have energy and techno-economic advantages and disadvantages. However, an optimal process may involve the integration of multiple technologies into a single, hybrid, transformative process that is more economical and energy efficient. The challenge of developing this type of process is the integration of rigorous process sub-models into a single framework, where hybrid designs can be evaluated and optimized. The National Energy Technology Laboratory (NETL) has significant expertise in the development of rigorous process models and modeling for the advancement and acceleration of the commercialization of carbon capture process systems. A large part of the effort is the Carbon Capture Simulation Initiative (CCSI). The computational tools and multi-scale modeling techniques comprising the CCSI Toolset can be broadly applied for the development of a wide variety of technologies well beyond carbon capture including chemicals production, petroleum refining, natural gas processing and biofuel production.

NineSigma, representing Novo Nordisk, seeks information on new or emerging technologies for delivery of protein and peptide based therapeutics, or on novel therapeutic approaches such as electroceutical technologies and bio-printing. Novo Nordisk is traveling to San Diego and San Francisco to hear in-person presentations from start-up companies or research groups in the San Diego area from June 9 - June 12, 2017 and San Francisco June 13 - June 15, 2017.

Background A large amount of the research and development of post-combustion carbon capture technology focuses on three main technologies: adsorption, absorption and membranes. Each of these technologies have energy and techno-economic advantages and disadvantages. However, an optimal process may involve the integration of multiple technologies into a single, hybrid, transformative process that is more economical and energy efficient. The challenge of developing this type of process is the integration of rigorous process sub-models into a single framework, where hybrid designs can be evaluated and optimized. The National Energy Technology Laboratory (NETL) has significant expertise in the development of rigorous process models and modeling for the advancement and acceleration of the commercialization of carbon capture process systems. A large part of the effort is the Carbon Capture Simulation Initiative (CCSI) [Reference 1]. The computational tools and multi-scale modeling techniques comprising the CCSI Toolset can be broadly applied for the development of a wide variety of technologies well beyond carbon capture including chemicals production, petroleum refining, natural gas processing and biofuel production.

The purpose of this Funding Opportunity Announcement (FOA) is to support bi-phasic developmental, discovery-driven, or hypothesis-driven research focused on innovative strategies to detect HIV either within the first two weeks of infection or to monitor viral rebound after stopping or developing resistance to antiretroviral therapy. Applications should propose simple diagnostic tools that would be feasible for a self-testing platform to allow untrained individuals to detect HIV. Interdisciplinary collaborations that include biomedical, physical, and behavioral sciences are highly encouraged.

The primary objective is to support scholarships for nuclear science, engineering, technology and related disciplines to develop a workforce capable of supporting the design, construction, operation, and regulation of nuclear facilities and the safe handling of nuclear materials. The primary objective is to support fellowships for nuclear science, engineering, technology and related disciplines to develop a workforce capable of supporting the design, construction, operation, and regulation of nuclear facilities and the safe handling of nuclear materials. The primary objective is to support faculty development for nuclear science, engineering, technology and related disciplines to develop a workforce capable of supporting the design, construction, operation, and regulation of nuclear facilities and the safe handling of nuclear materials. The grants specifically target probationary, tenure-track faculty during the first 6 years of their career and new faculty hires in the following academic areas: Nuclear, Mechanical, Civil, Environmental, Electrical, Fire Protection, Geotechnical, Structural and Materials Sciences Engineering as well as Health Physics. The program provides support to enable newer faculty to enhance their careers as professors and researchers in the university department where employed.

This Funding Opportunity Announcement (FOA) is associated with the Beau Biden Cancer MoonshotSM Initiative that is intended to accelerate cancer research. The purpose of this FOA is to increase case ascertainment and optimize delivery of evidence-based healthcare for individuals at high risk of cancer due to an inherited genetic susceptibility. Specifically, this FOA targets the following area designated as a scientific priority by the Blue Ribbon Panel (BRP) Recommendation E: "To realize the potential of cancer prevention and early detection in our nation, NCI should sponsor an initiative to improve the current state of early detection, genetic testing, genetic counseling, and knowledge landscape of the mechanisms and biomarkers associated with cancer development. This initiative should include demonstration projects that will show how cancer screening programs can simultaneously save lives, improve quality of life, and reduce healthcare costs."

The Fusion Energy Sciences (FES) program of the Office of Science (SC) and the Defense Program (DP) of the National Nuclear Security Administration (NNSA), both of the U.S. Department of Energy (DOE), jointly announce their interests in receiving grant applications for new awards and grant renewals for research in the SC-NNSA Joint Program in High-Energy-Density (HED) laboratory plasmas. All individuals or groups planning to submit applications for new or renewal funding in Fiscal Year 2018 should submit in response to this Funding Opportunity Announcement (FOA). The specific areas of interest are: 1. HED Hydrodynamics 2. Radiation-Dominated Dynamics and Material Properties 3. Magnetized HED Plasma Physics 4. Nonlinear Optics of Plasmas and Laser-Plasma Interactions 5. Relativistic HED Plasmas and Intense Beam Physics 6. Warm Dense Matter 7. High-Z, Multiply Ionized HED Atomic Physics 8. Diagnostics for HED Laboratory Plasmas More specific information on each area of interest is outlined in the general and program specific supplementary information provided.