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The Process Systems, Reaction Engineering and Molecular Thermodynamics program is part of the Chemical Process Systems cluster, which also includes: 1) the Catalysis program; 2) the Electrochemical Systems program; and 3) the Interfacial Engineering program. The goal of the Process Systems, Reaction Engineering and Molecular Thermodynamics program is to advance fundamental engineering research on the rates and mechanisms of chemical reactions, systems engineering and molecular thermodynamics as they relate to the design and optimization of chemical reactors and the production of specialized materials that have important impacts on society. The program supports the development of advanced optimization and control algorithms for chemical processes, molecular and multi-scale modeling of complex chemical systems, fundamental studies on molecular thermodynamics, and the integration of this information into the design of complex chemical reactors. An important area supported by the program focuses on the development of energy-efficient and environmentally-friendly chemical processes and materials. Proposals should focus on: · Chemical reaction engineering: This area encompasses the interaction of transport phenomena and kinetics in reactive systems and the use of this knowledge in the design of complex chemical reactors. Focus areas include novel reactor designs, such as catalytic and membrane reactors, micro-reactors, and atomic layer deposition systems; studies of reactions in supercritical fluids; novel activation techniques, such as plasmas, acoustics, and microwaves; design of multifunctional systems, such as "chemical-factory/lab-on-a-chip" concepts; and biomass conversion to fuels and chemicals. The program also supports new approaches that enable the design of modular chemical manufacturing systems.

The Critical Aspects of Sustainability (CAS) program includes the Division of Chemistry (CHE) and the Division of Materials Research (DMR) within the Directorate for Mathematical and Physical Sciences (MPS), the Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) and the Division of Civil, Mechanical and Manufacturing Innovation (CMMI) within the Directorate for Engineering (ENG), and the Division of Earth Sciences (EAR) within the Directorate for Geosciences (GEO).

The National Science Foundation (NSF) through its Divisions of Electrical, Communications and Cyber Systems (ECCS); Chemical, Bioengineering, Environmental and Transport Systems (CBET); Civil, Mechanical and Manufacturing Innovation (CMMI); Information and Intelligent Systems (IIS); and Mathematical Sciences (DMS) announces a solicitation on Multimodal Sensor Systems for Precision Health enabled by Data Harnessing, Artificial Intelligence (AI), and Learning. Next-generation multimodal sensor systems for precision health integrated with AI, machine learning (ML), and mathematical and statistical (MS) methods for learning can be envisioned for harnessing a large volume of diverse data in real time with high accuracy, sensitivity and selectivity, and for building predictive models to enable more precise diagnosis and individualized treatments. It is expected that these multimodal sensor systems will have the potential to identify with high confidence combinations of biomarkers, including kinematic and kinetic indicators associated with specific disease and disability. This focused solicitation seeks high-risk/high-return interdisciplinary research on novel concepts, innovative methodologies, theory, algorithms, and enabling technologies that will address the fundamental scientific issues and technological challenges associated with precision health.

NineSigma, representing a Fortune 500 global energy and chemical manufacturer, invites proposals for innovative technologies capable of recovering and re-purposing low grade heat waste generated by their crude oil refinery and petrochemical operations.

NineSigma, representing a multibillion-dollar chemical manufacturer, seeks a development partner for the technology to analyze the charge distribution or chemical composition of rugged/uneven surfaces.

NineSigma, representing a major component manufacturer, seeks non-destructive physical property measurement technologies, at a high speed, of carbon-fiber assembly. Of interest are not only those designed for characterizing carbon fiber but also those for versatile other applications. The client intends to provide potential partners with their knowledge and development resources, if necessary, to develop the technology further.

This Funding Opportunity Announcement (FOA) supports the optimization of potential therapeutic Biotechnology Products and Biologics (e.g., peptides, proteins, oligonucleotides, gene and cell therapies) for disorders identified under the NINDS mission. This track supports the further characterization and optimization of therapeutic lead(s) that showed promise as a potential therapeutic agent as evidenced by convincing animal proof-of-concept studies. Therefore, at the end of this funding period, successful projects will have delivered and optimized therapeutic candidate with demonstrated bioactivity, stability, manufacturability, bioavailability, in vivo efficacy and should be eligible for entry into the CREATE Bio Development track. The CREATE Bio Development track is a later stage program focused on the development of optimized therapeutic candidates through Investigational New Drug (IND)-enabling studies and submission of an IND package to the Food and Drug Administration (FDA). Also Listed under (U44)

NineSigma, representing a major manufacturer, seeks a technology to identify compounds contributing to the odor. Especially, proposals from organizations that are eager to conduct sample testing for the client's odorous gases are anticipated.

Pre-release of the latest topics in the Air Force's SBIR and STTR Commercial Solutions Opening program, which include COVID-19 pandemic materials and manufacturing advances, human performance and medical response advances/solutions and information sciences' advances/solutions

NineSigma, representing Betco Corporation, a privately held specialty chemical and equipment manufacturer, is seeking partners with solutions to clean, disinfect, and sanitize skin and surfaces. Novel products, technology advancements, or other approaches that can demonstrate efficacy to improve the overall cleanliness, health, and safety of commercial environments are of immediate interest.

The Centers for Chemical Innovation (CCI) Program supports research centers focused on major, long-term fundamental chemical research challenges. CCIs that address these challenges will produce transformative research, lead to innovation, and attract broad scientific and public interest. CCIs are agile structures that can respond rapidly to emerging opportunities through enhanced collaborations. CCIs integrate research, innovation, education, broadening participation, and informal science communication. The CCI Program is a two-phase program. Both phases are described in this solicitation. Phase I CCIs receive significant resources to develop the science, management and broader impacts of a major research center before requesting Phase II funding. Satisfactory progress in Phase I is required for Phase II applications; Phase I proposals funded in FY 2021 will seek Phase II funding in FY 2024. The FY 2021 Phase I CCI competition is open to projects in all fields supported by the Division of Chemistry, and must have scientific focus and the potential for transformative impact in chemistry. NSF Chemistry particularly encourages fundamental chemistry projects related to one or more of NSF's Big Ideas, including Quantum Leap, Understanding the Rules of Life, and Harnessing the Data Revolution. Similarly, the Division of Chemistry encourages CCI projects aligned with chemistry aspects of other articulated budget priorities, including Advanced Manufacturing, Artificial Intelligence, Biotechnology, and Quantum Information Science. More information on all of these is available in Section IX of this Program Solicitation.

The Emerging Frontiers in Research and Innovation (EFRI) program of the NSF Directorate for Engineering (ENG) serves a critical role in helping ENG focus on important emerging areas in a timely manner. This solicitation is a funding opportunity for interdisciplinary teams of researchers to embark on rapidly advancing frontiers of fundamental engineering research. For this solicitation, we will consider proposals that aim to investigate emerging frontiers in one of the following two research areas: Distributed Chemical Manufacturing (DCheM) Engineering the Elimination of End-of-Life Plastics (E3P) This solicitation will be coordinated with the Directorate for Biological Sciences, the Directorate for Mathematical and Physical Sciences and the Directorate for Social, Behavioral and Economic Sciences. EFRI seeks proposals with potentially transformative ideas that represent an opportunity for a significant shift in fundamental engineering knowledge with a strong potential for long term impact on national needs or a grand challenge. The proposals must also meet the detailed requirements delineated in this solicitation.