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Naval Surface Warfare Center (NSWC) Crane and the Office of the Undersecretary of Defense for Research and Engineering (OUSD(R&E))'s Joint Hypersonic Transition Office (JHTO) are interested in receiving research proposals in the following areas. Each will have a Period of Performance (PoP) of 12 months. a. Systems-level design of high-temperature composite materials and structures research utilization of fiber architectures and matrix compositions b. Novel position, navigation, and timing and adaptive flight controls c. Design-oriented models to optimize scramjet and multi-mode engines d. Simulation Methods for the Rapid Prediction of Hypersonic Environments e. Addressing the flow path processes that occur in rectangular or curved inlets and isolators including the destabilization that may occur due to junction flows or off-nominal flight conditions f. The development of methods and models including validation experiments and instrumentation to provide high quality data on multiphase blast properties and structural responses to structures g. Improving the understanding of rotating detonation rocket engine (RDRE) physics and developing design solutions for their inherent technical challenges h. Hypersonic Workforce Curricula Development

Growing Convergence Research (GCR) at the National Science Foundation was identified as one of 10 Big Ideas. Convergence research is a means for solving vexing research problems, in particular, complex problems focusing on societal needs. It entails integrating knowledge, methods, and expertise from different disciplines and forming novel frameworks to catalyze scientific discovery and innovation. GCR identifies Convergence Research as having two primary characteristics: Research driven by a specific and compelling problem. Convergence Research is generally inspired by the need to address a specific challenge or opportunity, whether it arises from deep scientific questions or pressing societal needs. Deep integration across disciplines. As experts from different disciplines pursue common research challenges, their knowledge, theories, methods, data, research communities and languages become increasingly intermingled or integrated. New frameworks, paradigms or even disciplines can form sustained interactions across multiple communities. A distinct characteristic of convergence research, in contrast to other forms of multidisciplinary research, is that from the inception, the convergence paradigm intentionally brings together intellectually diverse researchers and stakeholders to frame the research questions, develop effective ways of communicating across disciplines and sectors, adopt common frameworks for their solution, and, when appropriate, develop a new scientific vocabulary. Research teams practicing convergence aim at developing sustainable relationships that may not only create solutions to the problem that engendered the collaboration, but also develop novel ways of framing related research questions and open new research vistas.

This Funding Opportunity Announcement (FOA) encourages Small Business Innovative Research (SBIR) grant applications from small business concerns (SBCs) to address problems associated with the methods of collection, bioassay, isolation, purification, de-replication, yield, and supply that hamper the full utilization of natural products. 

This Funding Opportunity Announcement (FOA) encourages Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) to address problems associated with the methods of collection, bioassay, isolation, purification, de-replication, yield, and supply that hamper the full utilization of natural products. 

The Chemical Measurement and Imaging Program supports research focusing on chemically-relevant measurement science and chemical imaging, targeting both improved understanding of new and existing methods and development of innovative approaches and instruments.  Research areas include but are not limited to sampling and separation science; electroanalytical chemistry; spectrometry; and frequency- and time-domain spectroscopy.  Development of new chemical imaging and measurement tools probing chemical properties and processes are supported.  Innovations enabling the monitoring and imaging of chemical and electronic processes across a wide range of time and length scales are also relevant.  New approaches to data analysis and interpretation (including chemometrics) are encouraged.  Proposals addressing established techniques must seek improved understanding and/or innovative approaches to substantially broaden applicability.  Sensor-related proposals should address new approaches to chemical sensing, with prospects for broad utility and significant enhancement of current capabilities.

The Chemical Measurement and Imaging Program supports research focusing on chemically-relevant measurement science and chemical imaging, targeting both improved understanding of new and existing methods and development of innovative approaches and instruments.  Research areas include but are not limited to sampling and separation science; electroanalytical chemistry; spectrometry; and frequency- and time-domain spectroscopy.  Development of new chemical imaging and measurement tools probing chemical properties and processes are supported.  Innovations enabling the monitoring and imaging of chemical and electronic processes across a wide range of time and length scales are also relevant.  New approaches to data analysis and interpretation (including chemometrics) are encouraged.  Proposals addressing established techniques must seek improved understanding and/or innovative approaches to substantially broaden applicability.  Sensor-related proposals should address new approaches to chemical sensing, with prospects for broad utility and significant enhancement of current capabilities.

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program focuses on basic research that addresses fundamental questions regarding the chemistry of macromolecular, supramolecular and nanoscopic species and other organized structures and that advances chemistry knowledge in these areas.  Research of interest to this program will explore novel chemistry concepts in the following topics: (1) The development of novel synthetic approaches to clusters, nanoparticles, polymers, and supramolecular architectures; innovative surface functionalization methodologies; surface monolayer chemistry; and template-directed synthesis.  (2) The study of molecular-scale interactions that give rise to macromolecular, supramolecular or nanoparticulate self-assembly into discrete structures; and the study of chemical forces and dynamics that are responsible for spatial organization in discrete organic, inorganic, or hybrid systems (excluding extended solids).  (3) Investigations that utilize advanced experimental or computational methods to understand or to predict the chemical structure, unique chemical and physicochemical properties, and chemical reactivities that result from the organized or nanoscopic structures.  Research in which theory advances experiment and experiment advances theory synergistically is of special interest.

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program focuses on basic research that addresses fundamental questions regarding the chemistry of macromolecular, supramolecular and nanoscopic species and other organized structures and that advances chemistry knowledge in these areas.  Research of interest to this program will explore novel chemistry concepts in the following topics: (1) The development of novel synthetic approaches to clusters, nanoparticles, polymers, and supramolecular architectures; innovative surface functionalization methodologies; surface monolayer chemistry; and template-directed synthesis.  (2) The study of molecular-scale interactions that give rise to macromolecular, supramolecular or nanoparticulate self-assembly into discrete structures; and the study of chemical forces and dynamics that are responsible for spatial organization in discrete organic, inorganic, or hybrid systems (excluding extended solids).  (3) Investigations that utilize advanced experimental or computational methods to understand or to predict the chemical structure, unique chemical and physicochemical properties, and chemical reactivities that result from the organized or nanoscopic structures.  Research in which theory advances experiment and experiment advances theory synergistically is of special interest.

The Geobiology and Low-Temperature Geochemistry Program supports research on 1) the interactions between biological and geological systems at all scales of space and time; 2) geomicrobiology and biomineralization processes; 3) the role of life in the transformation and evolution of the Earth's geochemical cycles; 4) inorganic and organic geochemical processes occurring at or near the Earth's surface now and in the past, and at the broad spectrum of interfaces ranging in scale from planetary and regional to mineral-surface and supramolecular; 5) mineralogy and chemistry of soils and sediments; 6) surficial chemical and biogeochemical systems and cycles and their modification through natural and anthropogenic change; and 7) development of tools, methods, and models for low-temperature geochemistry and geobiological research - such as those emerging from molecular biology - in the study of the terrestrial environment.

This Funding Opportunity Announcement (FOA) encourages Small Business Innovative Research (SBIR) grant applications from small business concerns (SBCs) to address problems associated with the methods of collection, bioassay, isolation, purification, de-replication, yield, and supply that hamper the full utilization of natural products.

The Geobiology and Low-Temperature Geochemistry Program focuses on geochemical processes in terrestrial Earth's surface environmental systems, as well as the interaction of geochemical and biological processes. The program supports field, laboratory, theoretical, and modeling studies of these processes and related mechanisms at all spatial and temporal scales. Studies may address: 1) inorganic and/or organic geochemical processes occurring at or near the Earth's surface now and in the past, and across the broad spectrum of interfaces ranging in scale from planetary and regional to mineral-surface and supramolecular; 2) the role of life in the transformation and evolution of Earth's geochemical cycles; 3) surficial chemical and biogeochemical systems and cycles, including their modification through environmental change and human activities; 4) low-temperature aqueous geochemical processes; 5) mineralogy and chemistry of earth materials; 6) geomicrobiology and biomineralization processes; and 7) medical mineralogy and geochemistry. The Program encourages research that focuses on geochemical processes as they are coupled with physical and biological processes in the critical zone. The Program also supports work on the development of tools, methods, and models for the advancement of low-temperature geochemistry and geobiology. The Geobiology and Low-Temperature Geochemistry Program is interested in supporting transformational and cutting-edge research. The Program is highly interdisciplinary and interfaces with other programs within the Earth Surface Section and with programs in biology, chemistry and engineering.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) requests applications for the NIAMS Core Centers for Clinical Research (CCCR) (P30) within its mission. The CCCRs will provide avenues to advance the methodological sciences that support clinical research within and across the NIAMS' portfolio of diseases. The overall goals of the CCCR are to advance prevention, diagnosis and treatment of musculoskeletal, rheumatologic, and skin diseases by developing and fostering the implementation of novel methods, metrics, and outcome measures that address critical existing and emerging clinical research needs. 

Computational neuroscience provides a theoretical foundation and a rich set of technical approaches for understanding complex neurobiological systems, building on the theory, methods, and findings of computer science, neuroscience, and numerous other disciplines. Through the CRCNS program, the National Science Foundation (NSF), the National Institutes of Health (NIH), the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF), the French National Research Agency (Agence Nationale de la Recherche, ANR), and the United States-Israel Binational Science Foundation (BSF) support collaborative activities that will advance the understanding of nervous system structure and function, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system. 

TRANSLATIONAL MEDICINE AND THERAPEUTICS: The goal of the PhRMA Foundation's Translational Medicine and Therapeutics Program is to promote the development and use of experimental and computational methods in an integrative approach towards clinical needs in diagnosis, treatment and prevention. This can involve enhanced understanding of human biological and disease processes but requires a strong translational component. This program will support the concepts of Translational Medicine and Therapeutics as defined by the Foundation: "Translational medicine and therapeutics is a discipline focused on bridging experimental and computational technologies and discoveries in the research laboratory to their application in clinical practice. Examples of research components include activities in molecular and cellular biology, pathophysiology, systems biology, bioinformatics, modeling and simulation, and other quantitative sciences to connect basic biological concepts and entities to directly address unmet medical needs. The goals are to use clinical observation as the basis for hypothesis generation to further basic research and to efficiently advance the product of basic research to patients." Translational Medicine and Therapeutics awards will advance training and support career development of scientists engaged in research that significantly integrates cutting-edge technologies with advanced biological, chemical, and pharmacological sciences and engineering methodologies in such areas as (but not restricted to): * Genetics (Molecular, Pharmaco-, Population, Medical) * Genomics (Functional, Structural, Toxico-, Pharmaco-, Comparative) * Systems (Biology and Pharmacology) * Pathways and networks * Integrative biology * Modeling and simulation * Target Identification and Validation * Biomarker Discovery and Validation * Vaccine Development * Molecular Epidimiology * Imaging * Disease Modeling

The Beckman Young Investigator (BYI) Program is intended to provide research support to the most promising young faculty members in the early stages of academic careers in the chemical and life sciences particularly to foster the invention of methods, instruments and materials that will open up new avenues of research in science.

The Chemical and Biological Separations (CBS) program supports fundamental research on novel methods and materials for separation processes.  These processes are central to the chemical, biochemical, materials, energy, and pharmaceutical industries.  A fundamental understanding of the interfacial, transport, and thermodynamic behavior of multiphase chemical systems as well as quantitative descriptions of processing characteristics in the process-oriented industries is critical for efficient resource management and effective environmental protection.  The program encourages proposals that address emerging research areas and technologies, have a high degree of interdisciplinary thought coupled with knowledge creation, and integrate education and research.

The CSDM Program supports research on the nature of molecular structure and its consequences for reactivity, intermolecular interactions, and dynamics.   Chemical dynamics is defined to encompass reaction kinetics and mechanisms, intramolecular rearrangement or conformational changes, and changes induced via electromagnetic excitation.  While the majority of projects supported by CSDM are experimental in nature, the Program is receptive to research focused on utilizing applied computational methods.  However, the proposer should establish a high degree of relevance to the understanding of existing experimental data.  The CSDM Program is concerned primarily with chemical phenomena in the gas and fluid phases, as well as chemical processes at gas-fluid, gas-solid, fluid-solid, and fluid-fluid interfaces.  Proposals concerned with solid phase chemical processes are generally not supported by the Program. Proposals concerned with structure, dynamics or mechanisms as they pertain to catalytic processes should be submitted to the Chemical Catalysis Program (CHE/CAT). Proposals whose primary questions relate to phenomena arising from the properties of nanoscale materials or assemblies should be submitted to the Macromolecular, Supramolecular, and Nanochemistry Program (CHE/MSN). CSDM supports research projects that have strong implications for advancing the foundational physical models of chemical structure and dynamics. 

The Chemical Synthesis program focuses on the development of new, efficient synthetic methodologies and on the synthesis of complex and/or challenging molecules.  Typical synthetic targets involve novel structures, structures displaying unique properties, or structures providing pathways to discover and elucidate new phenomena.  Examples of supported research areas include the development of innovative reagents, catalysts for synthetic transformations, discovery of new synthetic methods, target-oriented synthesis, green synthesis, and synthesis of novel organic, organometallic, and inorganic structures.  Research in this program will generate fundamental knowledge of chemical synthesis that enables the development of new avenues of basic chemical research and transformative technologies. 

The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications focusing on integrated, transdisciplinary research that would advance scientific understanding of potential for impacts to ecosystem wellbeing associated with the use of manufactured chemicals. Specifically, the RFA would solicit proposals for systems-based research to develop and apply innovative metrics and modeling approaches to improve evaluation of ecological resilience and impact analyses, and to support environmental sustainability. Successful proposals will translate emerging and advanced methods, data, and computational tools to address complexity of these systems and distill drivers of adverse outcomes to ecological organisms and populations.

The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications focusing on integrated, transdisciplinary research that would advance scientific understanding of potential for impacts to ecosystem wellbeing associated with the use of manufactured chemicals. Specifically, the RFA would solicit proposals for systems-based research to develop and apply innovative metrics and modeling approaches to improve evaluation of ecological resilience and impact analyses, and to support environmental sustainability. Successful proposals will translate emerging and advanced methods, data, and computational tools to address complexity of these systems and distill drivers of adverse outcomes to ecological organisms and populations.

The Chemical and Biological Separations (CBS) program supports fundamental research on novel methods and materials for separation processes.  These processes are central to the chemical, biochemical, materials, energy, and pharmaceutical industries.  A fundamental understanding of the interfacial, transport, and thermodynamic behavior of multiphase chemical systems as well as quantitative descriptions of processing characteristics in the process-oriented industries is critical for efficient resource management and effective environmental protection.  The program encourages proposals that address emerging research areas and technologies, have a high degree of interdisciplinary thought coupled with knowledge creation, and integrate education and research. Research topics OF PARTICULAR INTEREST in CBS include fundamental molecular-level work on: Nanostructured materials for separations Biorenewable resource separation processes Purification of drinking water Field (flow, magnetic, electrical) induced separations Separation of molecular constituents from blood The duration of unsolicited awards is generally one to three years.  The average annual award size for the program is $80,000.  Proposals requesting a substantially higher amount than this, without prior consultation with the Program Director, may be returned without review.  Small equipment proposals of less than $100,000 will also be considered and may be submitted during the annual submission window. 

The National Institute on Drug Abuse (NIDA) intends to solicit proposals from offerors having the capability to perform the following tasks: (1) cultivate and harvest, process, analyze, store, and distribute cannabis (marijuana) for research, (2) extract cannabis to produce pure and standardized (current Good Manufacturing Practices (cGMP)-grade) cannabis extracts containing varying concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), (3) isolate cGMP and research grade THC, CBD, and other cannabinoids, (4) periodically analyze cannabis extracts, and isolated cannabinoids for authenticity, purity and stability, (5) develop new methods for growing cannabis plants containing high THC, low CBD; high CBD, low THC; and equal strength of CBD and THC, (6) manufacture, analyze, determine stability, store, and supply marijuana cigarettes, and (7) supply cannabis, cannabis extract, other phyto-cannabinoids, and marijuana cigarettes to research investigators and/or to the NIDA Drug Supply program upon NIDA authorization.