Group items tagged

To continue making safe and effective topical semisolid drug products available to the American public, it is essential that FDA's regulatory science, as well as best practices in the pharmaceutical industry, are informed by the most current understanding of the product quality attributes that are potentially critical to the therapeutic performance of topical semisolid dosage forms. The scope of this project is to characterize all measurable physical/chemical qualities of different dosage forms of semisolid topical drug products, identify appropriate methodologies for measuring each of these quality attributes, characterize formulation and manufacturing parameters that alter the arrangement of matter in the dosage form as measured by specific quality attributes, and utilize in vitro and/or in vivo measures of product performance to correlate variations in critical quality attributes with a failure mode for a drug product.  

NOAA's Office of Ocean Exploration & Research (OER) is soliciting pre-proposals followed by full proposals for bold, innovative, multi-partner, interdisciplinary ocean exploration projects in the following areas of interest: 1) physical, chemical and biological characterizations of unknown or poorly known regions of the deep ocean, especially areas deeper than 500 m. 2) baseline characterization of marine archaeological resources at any depth; and 3) technology that advances ocean exploration and has application to NOAA related missions. 

Bioequivalence studies that compare a reference formulation to an investigational formulation are typically conducted in healthy adult volunteers and occasionally are conducted in patients. Some populations have unique physical, biological, and physiological considerations that are not reflected by healthy volunteers or by the typical patient for whom a drug is indicated. Physicians have expressed concerns about generic drug substitution (especially for narrow therapeutic index drugs) in special patient populations whose experience with a drug may not be represented by those in whom bioequivalence studies are conducted. For instance, for products that do not have age-appropriate formulations (e.g., formulations do not differ by age of patient), the use of generic products under "off-label" practice patterns in special populations such as crushing or dissolving tablets in liquid for pediatric patients may influence their equivalence to brand name products. Special populations include, but are not limited to, pediatric patients, elderly patients who take multiple medications, women (particularly those who are pregnant), racial/ethnic minorities, and/or individuals with impaired kidney or liver function.

n 2016, the National Science Foundation (NSF) unveiled a set of "Big Ideas," 10 bold, long-term research and process ideas that identify areas for future investment at the frontiers of science and engineering (seehttps://www.nsf.gov/news/special_reports/big_ideas/index.jsp). The Big Ideas represent unique opportunities to position our Nation at the cutting edge of global science and engineering leadership by bringing together diverse disciplinary perspectives to support convergence research. As such, when responding to this solicitation, even though proposals must be submitted to the Directorate for Mathematical & Physical Sciences/Office of Multidisciplinary Activities (MPS/OMA),once received, the proposals will be managed by a cross-disciplinary team of NSF Program Directors. The Quantum Idea Incubator for Transformational Advances in Quantum Systems (QII - TAQS) program is designed to support interdisciplinary teams that will explore highly innovative, original, and potentially transformative ideas for developing and applying quantum science, quantum computing, and quantum engineering. Proposals with the potential to deliver new concepts, new platforms, and/or new approaches that will accelerate the science, computing, and engineering of quantum technologies are encouraged. Breakthroughs in quantum sensing, quantum communications, quantum simulations, or quantum computing systems are anticipated.

The overall goals of the Bioinformatics Center are to provide a database and associated tools for storage and integration of clinical physiological and metabolic data along with multiple types of chemical analysis data derived through metabolomics, proteomics, genomics, transcriptomics, or similar technologies. 

The mission of BTO is to foster, demonstrate, and transition breakthrough fundamental research, discoveries, and applications that integrate biology, engineering, computer science, mathematics, and the physical sciences. BTO's investment portfolio goes far beyond life sciences applications in medicine to include areas of research such as human-machine interfaces, microbes as production platforms, and deep exploration of the impact of evolving ecologies and environments on U.S. readiness and capabilities. BTO's programs operate across a wide range of scales, from individual cells to the warfighter to global ecosystems. BTO responds to the urgent and long-term needs of the Department of Defense (DoD) and addresses national security priorities.

AFOSR plans, coordinates, and executes the Air Force Research Laboratory's (AFRL) basic research program in response to technical guidance from AFRL and requirements of the Air Force. Additionally, the office fosters, supports, and conducts research within Air Force, university, and industry laboratories; and ensures transition of research results to support U.S. Air Force needs. The focus of AFOSR is on research areas that offer significant and comprehensive benefits to our national war fighting and peacekeeping capabilities. These areas are organized and managed in two scientific Departments: Engineering and Information Science (RTA) and Physical and Biological Sciences (RTB). The research activities managed within each Department are summarized in this section.

The Critical Aspects of Sustainability (CAS) program includes the Division of Chemistry (CHE) and the Division of Materials Research (DMR) within the Directorate for Mathematical and Physical Sciences (MPS), the Division of Chemical, Bioengineering, Environmental and Transport Systems (CBET) and the Division of Civil, Mechanical and Manufacturing Innovation (CMMI) within the Directorate for Engineering (ENG), and the Division of Earth Sciences (EAR) within the Directorate for Geosciences (GEO).

OBJECTIVE: This is an AF Special Topic partnership, please see the above AF Special Topic instructions for further details. A Phase I award will be completed over 3 months with a maximum award of $25K and a Phase II may be awarded for a maximum period of 12 months DESCRIPTION: Academia is producing disruptive science and technology innovations at an increasingly rapid pace. Hence, rather than utilizing a pre-defined requirements approach, this topic is intended to be an open call for ideas and technologies that may not be currently listed (i.e. the unknown-unknown) under STTR topics, but nonetheless still fit within broad interest areas of the Air Force basic research level. These broad areas (Engineering and Complex Systems, Information and Networks, Physical Sciences, and Chemistry/Biological Sciences) are covered in greater detail at wpafb.af.mil/Welcome/Fact-Sheets/Display/Article/842026. To be eligible, offeror(s) must be teams that have formed companies and partnered with a university (e.g. university entrepreneurship centers, university technology transfer offices). The offeror should demonstrate their technical capability by demonstrating a credible and high-potential minimum viable product (MVP) along with a credible plan for developing the prototype to a commercially available solution. This topic is not looking for fully formed products, and it is acceptable if the solutions are earlier stage.

The National Institute of Environmental Health Sciences (NIEHS) invites qualified investigators from domestic institutions of higher education to apply to the Superfund Research Program (SRP) R01 Individual Research Project grant program. The mission of the NIEHS is to discover how the environment affects people in order to promote healthier lives. The NIEHS Superfund Research Program (SRP) (http://www.niehs.nih.gov/research/supported/srp/) was established under the Superfund Amendment Reauthorization Act (SARA) Section 311(a), which authorizes NIEHS to implement a university-based program of basic research for the development of: 1) advanced techniques for the detection, assessment, and evaluation of the effect of hazardous substances on human health; 2) methods to assess the risks to human health presented by hazardous substances; 3) methods and technologies to detect hazardous substances in the environment; and 4) basic biological, chemical, and physical methods to reduce the amount and/or toxicity of hazardous substances. SRP's broad scope, as dictated by the SARA mandates, allows NIEHS to support scientific research to address the wide array of scientific uncertainties facing the national Superfund program utilizing biomedical as well as environmental science and engineering approaches. Research supported by the SRP uses mechanistic science as a foundation and, in keeping with the broad research themes of the program mandates, the SRP promotes an interdisciplinary approach to develop solutions for the safe management of hazardous substances with the ultimate goal of improving public health.

With this solicitation, NIJ seeks proposals for basic or applied research and development projects. An NIJ forensic science research and development grant supports a discrete, specified, circumscribed project that will: (1) increase the body of knowledge to guide and inform forensic science policy and practice, or (2) lead to the production of useful material(s), device(s), system(s), or method(s) that have the potential for forensic application. The intent of this program is to direct the findings of basic scientific research; research and development in broader scientific fields applicable to forensic science; and ongoing forensic science research toward the development of highly-discriminating, accurate, reliable, cost-effective, and rapid methods for the identification, analysis, and interpretation of physical evidence for criminal justice purposes. Projects should address the challenges and needs of the forensic science community. The operational needs discussed at NIJ's FY 2016 Forensic Science TWG meeting may be found on NIJ.gov. Additional research needs of the forensic science community can be found at the Organization of Scientific Area Committees website. While the goals and deliverables of proposed projects do not necessarily need to result in immediate solutions to the posted challenges or needs, they should speak to them and produce knowledge that adds to work towards eventual resolutions.

The purpose of this Funding Opportunity Announcement (FOA) is to support bi-phasic developmental, discovery-driven, or hypothesis-driven research focused on innovative strategies to detect HIV either within the first two weeks of infection or to monitor viral rebound after stopping or developing resistance to antiretroviral therapy. Applications should propose simple diagnostic tools that would be feasible for a self-testing platform to allow untrained individuals to detect HIV. Interdisciplinary collaborations that include biomedical, physical, and behavioral sciences are highly encouraged.

1. Lithium-ion Battery Safety. Safety concerns continue to hamper full adoption of lithium-ion batteries for defense systems, despite significant research investments by the government and the private sector. This Defense initiative will advance promising lithium-ion battery safety technologies at university research laboratories into early laboratory prototypes and potentially minimum viable products for adoption by the defense and commercial sectors via early startups, small businesses and non-traditional defense contractors. Specific technical areas of interest include, but are not limited to, the following: improved electrolytes; stable high-energy anodes and cathodes; cell components and structures that enhance safety and reliability (e.g. use of electrode coatings and electrolyte additives); safety optimization through battery and battery module design and packaging; and battery management and state of health techniques that prevent and/or mitigate catastrophic failure. 2. Electrical Grid Reliability, Resiliency and Security. Both the defense and commercial sectors recognize the ever-growing criticality to enhance electrical grid reliability, resiliency and security through innovation at the component and system levels. This Defense initiative will advance relevant electrical grid innovations at university research laboratories into early laboratory prototypes and potentially minimum viable products for adoption by the defense and commercial sectors via early startups, small businesses and non-traditional defense contractors. Specific technical areas of interest include, but are not limited to, the following: advanced electrical power generation, transmission and distribution hardware and software; physical cyber secured industrial controls hardware and software; effective control of microgrids supporting high-dynamic loads; electrical grid protocols and controls to maintain secured operations of critical infrastructure under adverse conditions; hardening of e

The Petrology and Geochemistry Program supports basic research on the formation of planet Earth, including its accretion, early differentiation, and subsequent petrologic and geochemical modification via igneous and metamorphic processes. Proposals in this program generally address the petrology and high-temperature geochemistry of igneous and metamorphic rocks (including mantle samples), mineral physics, economic geology, and volcanology. Proposals that are focused on the development of analytical tools, theoretical and computational models, and experimental techniques for applications by the igneous and metamorphic petrology, and high temperature geochemistry and geochronology communities are also invited.

The Blavatnik National Awards honor America's most innovative young faculty-rank scientists and engineers. These awards celebrate the past accomplishments and future potential of young faculty members working in the three disciplinary categories of Life Sciences, Physical Sciences & Engineering, and Chemistry. Every year, one Blavatnik National Awards Laureate in each disciplinary category will receive $250,000 in unrestricted funds, and additional nominees will be recognized as Finalists. Nominations are accepted from an invited group of research universities, independent research institutions, academic medical centers, and government laboratories from around the United States, as well as from the Awards' own Scientific Advisory Council, composed of renowned science and technology leaders. Miami University is an invited institution. If you are interested in being nominated, please contact Heather Johnston (johnsthb@MiamiOH.edu) in the Office of Research & Innovation.

We are looking for ideas that can lead to new multi-grant research portfolios on human flourishing. We are particularly interested in ideas for interdisciplinary scientific research towards discoveries that can promote physical, mental, social, and spiritual well-being. We welcome ideas that bridge gaps between empirical science and the humanities. Such ideas may include (but are not limited to):  Experimental testing of philosophically grounded models of human flourishing; Research on biological complexity in humans, including genetics, epigenetics, and microbiome research; Investigation of key psychological, neuroscientific, or human developmental concepts, such as (but not limited to) altruism, creativity, imagination, narrative, and meta-cognition; Research on cognitive, affective, or social capacities of individuals or groups; Studies of human biological or cultural evolution.

The Cottrell Scholar Award (CSA) is available to early career faculty at US and Canadian research universities and primarily undergraduate institutions. Eligible applicants are tenure-track faculty who hold primary or courtesy appointments in chemistry, physics, or astronomy departments that offer bachelor's and/or graduate degrees in the applicant's discipline, For the 2020 proposal cycle, eligibility is limited to faculty members who started their first tenure-track appointment anytime in calendar year 2017. Accommodations are made for faculty who have taken maternity or paternity leave, or who have experienced medical conditions that prompted a tenure clock extension.

This Funding Opportunity Announcement (FOA) invites exploratory/developmental applications that propose transformative engineering solutions to technical challenges associated with meaningful development, substantial optimization of existing technologies and clinical translation of intraoral biodevices. Proposed technologies are expected to advance development of oral biodevices to clinical use, including but not limited to: precision medicine-based detection, diagnosis and treatment of oral and overall health conditions, and measurement of patient functional status and clinical outcome assessment. Areas of interest in this FOA include engineering approaches that allow integration of electronic, physical, and biological systems essential to the development of functional biodevices that are safe and effective for detection, diagnosis and treatment of oral and systemic disease. Products of this research will be proof-of-concept prototype biodevices, dedicated biosensors and associated core technologies that enable development of safe and effective intra-oral biodevices intended for specific clinical applications. To streamline the development of oral biodevices that advance precision medicine-based approaches in clinical practice, this FOA encourages interdisciplinary collaborations across engineering, multifunctional sensors, pharmacology, chemistry, medicine, and dentistry, as well as between academia and industry.

Naval Surface Warfare Center (NSWC) Crane and the Office of the Undersecretary of Defense for Research and Engineering (OUSD(R&E))'s Joint Hypersonic Transition Office (JHTO) are interested in receiving research proposals in the following areas. Each will have a Period of Performance (PoP) of 12 months. a. Systems-level design of high-temperature composite materials and structures research utilization of fiber architectures and matrix compositions b. Novel position, navigation, and timing and adaptive flight controls c. Design-oriented models to optimize scramjet and multi-mode engines d. Simulation Methods for the Rapid Prediction of Hypersonic Environments e. Addressing the flow path processes that occur in rectangular or curved inlets and isolators including the destabilization that may occur due to junction flows or off-nominal flight conditions f. The development of methods and models including validation experiments and instrumentation to provide high quality data on multiphase blast properties and structural responses to structures g. Improving the understanding of rotating detonation rocket engine (RDRE) physics and developing design solutions for their inherent technical challenges h. Hypersonic Workforce Curricula Development

The Emerging Frontiers in Research and Innovation (EFRI) program of the NSF Directorate for Engineering (ENG) serves a critical role in helping ENG focus on important emerging areas in a timely manner. This solicitation is a funding opportunity for interdisciplinary teams of researchers to embark on rapidly advancing frontiers of fundamental engineering research. For this solicitation, we will consider proposals that aim to investigate emerging frontiers in one of the following two research areas: Distributed Chemical Manufacturing (DCheM) Engineering the Elimination of End-of-Life Plastics (E3P) This solicitation will be coordinated with the Directorate for Biological Sciences, the Directorate for Mathematical and Physical Sciences and the Directorate for Social, Behavioral and Economic Sciences. EFRI seeks proposals with potentially transformative ideas that represent an opportunity for a significant shift in fundamental engineering knowledge with a strong potential for long term impact on national needs or a grand challenge. The proposals must also meet the detailed requirements delineated in this solicitation.