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The Children's Heart Foundation's 2020 Call for Research Proposals is now open! The Children's Heart Foundation funds life-saving, life-changing congenital heart defect (CHD) research in clinical cardiology, translational research, population science, and advancement, prevention, detection of surgical and interventional techniques including, but not limited to the following areas:  Genetics Biochemistry Pharmacology Devices and procedural research (cardiac catheterization and surgery) Neurodevelopmental and functional outcomes Quality and policy regarding delivery of care, coverage, and access Maternal environment and modifiable disease impact on fetuses with CHD Fetal diagnosis and intervention Long-term care of adults with CHDs Technological development and advancements

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support the development of comprehensive reference epigenomes for male and female gametes, and pre-implantation embryos after exposure to a particular environmental factor/insult.  What is envisioned is the establishment of a compendium/atlas annotating epigenetic changes during various stages of spermatogenesis, oogenesis, and pre-implantation embryo development, the identification of the affected genes, and the characterization of any resulting phenotype in the offspring.

The purpose of this FOA is to stimulate the development of innovative research strategies aimed at increasing the understanding of the molecular and cellular changes in the cytoskeleton that occur during the aging process.  Applications considering the effect of age on factors such as cytoskeleton structure and function, the impact of the cytoskeleton on intracellular organelle interactions, and signaling or regulatory molecules controlling cellular architecture are encouraged.  There is also interest in studying the role of the cytoskeleton in nuclear-cytoplasmic communications, and in spatio-temporal relationships during the aging process and in age-related diseases.

The purpose of this FOA is to support the expansion of the National Institute of Neurological Disorders and Stroke (NINDS) Human Cell and Data Repository. The repository will maintain the current collection of fibroblast and induced pluripotent stem cell (iPSC) lines as well as develop, characterize, expand and where appropriate genetically modify new high-quality iPSC, fibroblast cell lines and peripheral blood monocyte cells in accordance with the NINDS mission.  The NINDS Human Cell and Data Repository will distribute human cell resources broadly to qualified academic and industry researchers.   

This Funding Opportunity Announcement (FOA) solicits research projects focused on the process of effective communication of research findings about breast cancer and the environment. A central objective of this new initiative is to ensure effective translation of findings that result in risk messaging that is understood by targeted audiences.  The ultimate goal is to provide the scientific evidence for developing communication-based prevention efforts to reduce the risk for breast cancer from environmental factors.