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The National Institute on Aging is seeking applications on systems biology approaches using non-mammalian laboratory animal models to increase our understanding of the basic biology underpinning neurodegeneration. It is expected that research supported under this FOA will provide new insights into molecular networks that might be involved in causing, amplifying or protecting against neurodegeneration, and that, in turn, might ultimately contribute to Alzheimer's disease or related dementias. Importantly, a major goal of this FOA is to use interaction and regulatory networks produced and analyzed using systems biology to gain these new insights. Because this FOA is directed toward discovery, currently employed genetically modified laboratory animals used to study AD are not required, although they may be used. Because this FOA requires systems biology approaches, data used to build interaction or regulatory networks may also come from humans or other mammals in which AD, related dementias, or aging-related cognitive decline have been observed. This FOA will only support studies using non-mammalian laboratory animal models; studies involving humans or experiments with mammals will not be allowed under this FOA.

This Funding Opportunity Announcement (FOA) invites applications proposing research on the specific role of aging biology in the development, etiology and treatment of Alzheimer's disease. Aging is by far the main risk factor for most chronic diseases, a fact recognized by the field of geroscience. Recent advances in the fields of basic aging biology and geroscience now allow researchers to address mechanistically the role of aging in Alzheimers disease. Applications that make use of geroscience principles and test the role of different hallmarks of aging biology are specifically appropriate, while those focused solely on aging biology, or solely on Alzheimers disease will be deemed unresponsive to the FOA.

This Funding Opportunity Announcement (FOA) invites applications proposing research on the specific role of aging biology in the development, etiology and treatment of Alzheimer's disease. Aging is by far the main risk factor for most chronic diseases, a fact recognized by the field of geroscience. Recent advances in the fields of basic aging biology and geroscience now allow researchers to address mechanistically the role of aging in Alzheimers disease. Applications that make use of geroscience principles and test the role of different hallmarks of aging biology are specifically appropriate, while those focused solely on aging biology, or solely on Alzheimers disease will be deemed unresponsive to the FOA.

This Funding Opportunity Announcement (FOA) invites applications proposing research on the specific role of aging biology in the development, etiology and treatment of Alzheimer's disease. Aging is by far the main risk factor for most chronic diseases, a fact recognized by the field of geroscience. Recent advances in the fields of basic aging biology and geroscience now allow researchers to address mechanistically the role of aging in Alzheimer's disease. Applications that make use of geroscience principles and test the role of different hallmarks of aging biology are specifically appropriate, while those focused solely on aging biology, or solely on Alzheimer's disease will be deemed nonresponsive to the FOA.

This Funding Opportunity Announcement (FOA) invites applications proposing research on the specific role of aging biology in the development, etiology and treatment of Alzheimer's disease. Aging is by far the main risk factor for most chronic diseases, a fact recognized by the field of geroscience. Recent advances in the fields of basic aging biology and geroscience now allow researchers to address mechanistically the role of aging in Alzheimer's disease. Applications that make use of geroscience principles and test the role of different hallmarks of aging biology are specifically appropriate, while those focused solely on aging biology, or solely on Alzheimer's disease will be deemed nonresponsive to the FOA.

The National Institute on Aging is seeking applications to develop systems biology approaches to understand the basic biology underpinning neurodegeneration which might ultimately contribute to Alzheimer's disease or related dementias, using non-mammalian laboratory animal models. It is expected that research carried under the auspices of this FOA will lead to discovery of new mechanisms that provoke neurodegeneration and to new molecular pathways that might be involved in causing, amplifying or protecting against neurodegeneration. Applications should propose to use established non-mammalian laboratory animals which have a history of contributions to our understanding of neurobiology or aging biology.  

This FOA will use the NIH Resource-Related Research Project (R24) mechanism to facilitate the development of research networks to advance research on the basic biology of aging in health disparities. The infrastructure-building aspect of this FOA will be to establish collaborations for subsequent research on the biology of aging underlying health disparities. The intention is to provide a platform for discovery and pilot projects to establish feasibility of novel approaches to be used by these collaborations. For this FOA, the key human population feature of health disparities is accelerated aging.

The emergent field of geroscience seeks to relate the biology of aging to the development of chronic diseases and the onset of degenerative conditions which are prevalent in the older segment of human populations. It is generally accepted that age is the major risk factor for most chronic diseases and degenerative conditions in adults. Thus, a critical question in geroscience is to identify components in the biology of aging that are the underlying risk for multiple chronic diseases and degenerative conditions. Therefore, this FOA will support planning grants to circumscribe the scope of this question and suggest ways to answer it experimentally. The focus will be on epigenetics underlying aging as a risk factor for age-related diseases and degenerative conditions in humans. Mortality and age-related mortality are outside the scope of this FOA. Studies using model organisms are outside the scope of this FOA.

The emergent field of geroscience seeks to relate the biology of aging to the development of chronic diseases and the onset of degenerative conditions which are prevalent in the older segment of human populations. It is generally accepted that age is the major risk factor for most chronic diseases and degenerative conditions in adults. Thus, a critical question in geroscience is to identify components in the biology of aging that are the underlying risk for multiple chronic diseases and degenerative conditions. Therefore, this FOA will support planning grants to circumscribe the scope of this question and suggest ways to answer it experimentally. The focus will be on epigenetics underlying aging as a risk factor for age-related diseases and degenerative conditions in humans. Mortality and age-related mortality are outside the scope of this FOA. Studies using model organisms are outside the scope of this FOA.

The purpose of this Funding Opportunity Announcement (FOA) is to stimulate collaborative research to understand the biological mechanisms of aging in dental, oral, and craniofacial (DOC) tissues, as they relate to parallel processes in other tissues and organs. The areas of emphasis under this FOA include inflammation, tissue healing and regeneration, and epigenetic regulation. The overarching long-term goal of this effort is to improve oral health in older adults by addressing knowledge gaps in our understanding of the basic biology of age-associated changes in health and disease states of DOC tissues. Also listed under R01

This FOA invites exploratory comparative biology research projects assessing how different animal species respond to challenges and damage to cellular physiology pathways that might influence the onset of Alzheimer's and other neurodegenerative diseases as well as resilience to them, such as adaptation to stress, macromolecular damage, proteostasis and stem cell function and regeneration.    

The Biological Anthropology Program supports basic research in areas related to human evolution and contemporary human biological variation. Research areas supported by the program include, but are not limited to, human genetic variation, human adaptation, human osteology and bone biology, human and nonhuman primate paleontology, functional anatomy, and primate socioecology. Grants supported in these areas are united by an underlying evolutionary framework, and often a consideration of adaptation as a central theoretical theme. Many proposals also have a biocultural orientation. The program frequently serves as a bridge within NSF between the social and behavioral sciences and the natural and physical sciences, and proposals are commonly jointly reviewed and funded with other programs.

The Biological Anthropology Program supports basic research in areas related to human evolution and contemporary human biological variation. Research areas supported by the program include, but are not limited to, human genetic variation, human adaptation, human osteology and bone biology, human and nonhuman primate paleontology, functional anatomy, and primate socioecology. Grants supported in these areas are united by an underlying evolutionary framework, and often a consideration of adaptation as a central theoretical theme. Many proposals also have a biocultural orientation. The program frequently serves as a bridge within NSF between the social and behavioral sciences and the natural and physical sciences, and proposals are commonly jointly reviewed and funded with other programs.

The goal of this funding opportunity announcement is to continue and expand the open-science, systems-biology enterprise of the AMP-AD Target Discovery and Preclinical Validation Consortium and enable data-driven discovery and validation of novel targets and biomarkers for AD and AD-related dementias through the development of predictive network models of brain health and disease.

The Ellison Medical Foundation Senior Scholar program is designed to support established investigators working at institutions in the U.S. to conduct research in the basic biological and basic biomedical sciences relevant to understanding lifespan development processes and age-related diseases and disabilities. The award is intended to provide significant support to allow the development of new, creative research programs by investigators who may not currently be conducting aging research or who wish to develop new research programs in aging. The Foundation particularly seeks to stimulate new research that has rigorous scientific foundations but is currently inadequately funded, either because of its perceived novelty, high risk, or because it is from an area where other "traditional" research interests absorb most funding. Areas of interest include, but are not limited to Structural biology Molecular genetics Studies with model systems ranging from lower eukaryotes to humans Inquiries testing the relevance of simpler models to human aging Genetic epidemiology of aging; candidate longevity genes Aging in the immune system Host defense molecules in aging systems Mechanisms of free radical induced cell aging Mechanisms of aging in various differentiated cell populations Gene/environment and gene/gene interactions Integrative physiology New approaches to age-modulated disease mechanisms

In order to continue to attract new generations of talented investigators, the Glenn/AFAR Scholarships for Research in the Biology of Aging have been established.  The program is designed to give students enrolled in MD, DO, PhD, or combined-degree programs the opportunity to conduct a three-to-six-month research project focused on biomedical research in aging.  The program aims to give students the chance to learn more about the field of aging research, as well as increase their understanding of the challenges involved in improving the quality of life for older people.

This Funding Opportunity Announcement (FOA) invites pilot/feasibility projects that propose basic, clinical, or translational research on underactive bladder (UAB) and its consequences in aging and in older persons. Applications should focus on the 1) biology, etiology and pathophysiology of UAB in animal models and/or older adults;  2) translation of basic/clinical research into clinical practice and health decision-making; 3) diagnosis, prevention, management and clinical outcomes of UAB in older adults; and/or 4) epidemiology and risk factors for the development of UAB with advancing age. Pilot/feasibility research supported by this initiative should enhance knowledge of UAB and its consequences in older adults and provide evidence of feasibility of the diagnosis, evaluation, and/or treatment of UAB in older persons.

Through its Science of Hope and Optimism Funding Initiative program, the association will award two-year grants of up to $250,000 for research projects that use a variety of methods to explore the nature of hope and optimism. Priority will be given to projects in cognitive, developmental, personality, health, and social psychology, as well as sociology. Interdisciplinary teams that include members from cognate areas - e.g., cognitive science, anthropology, nursing, and biology - are encouraged.

Proposals in areas where support from the National Institutes of Health or other traditional funding sources is unlikely because the research is high risk are particularly encouraged if they have potential to lead to major new advances in the understanding of basic mechanisms of aging. Projects investigating age-related diseases also qualify, but only if approached from the point of view of how basic aging processes may lead to these outcomes. Projects concerning mechanisms underlying common geriatric functional disorders are encouraged, as long as these include connections to fundamental problems in the biology of aging. Projects that deal strictly with clinical problems such as the diagnosis and treatment of disease, health outcomes, or the social context of aging are not eligible.

The goal of this Funding Opportunity Announcement (FOA) is to support innovative research focused on understanding the molecular and cellular mechanisms underlying the heterogeneity and multifactorial nature of Alzheimer's disease (AD) with the potential to create new or challenge existing scientific paradigms. This FOA encourages individual or collaborative research projects that propose innovative approaches to understand the complex biology of AD aimed to fill critical knowledge gaps.

The Chan Zuckerberg Initiative invites applications to join the CZI Neurodegeneration Challenge Network an interdisciplinary collaborative initiative to increase understanding of the fundamental biology of neurodegenerative disorders. Applications are being accepted for two funding mechanisms: Awards are worth $350K total costs per year for three years, for a total of $1.05M (including up to 15% indirect costs). The CZI Neurodegeneration Challenge Network has three goals: (1) to make fundamental advances toward understanding neurodegeneration; (2) to bring new ideas and talent to the field of neurodegeneration; and (3) to encourage a new type of interdisciplinary collaborative research involving scientists, clinicians and engineers