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The program aims to support hit-to-lead optimization through investigational new drug (IND)-enabling studies. To that end, grants of $600,000 over two years will be awarded in support of proposals with the potential to advance discovery into meaningful therapeutics to treat, prevent, or slow Alzheimer's disease or related dementias. Funding priorities identified by ADDF include drug targets related to proteostatis (autophagy, lysosomal biogenesis, proteasomal degradation, post-translational modifications associated with proteostasis, protein folding/misfolding, endoplasmic reticulum stress, and extracellular clearance) and neurovascular health (blood brain barrier function and integrity, cerebral hypoperfusion, nutrient supply to the brain, and endothelial interaction with pericytes and astrocytes).

The American Psychological Foundation provides financial support for innovative research and programs that enhance the power of psychology to elevate the human condition and advance human potential, both today and for generations to come. As part of this mission, APF is accepting applications for its APF Trauma Psychology Grant. Through the annual program, a single grant of up to $3,000 will be awarded in support innovative work aimed at alleviating trauma. To be eligible, applicants must be an early-career psychologist (no more than ten years postdoctoral); be affiliated with a nonprofit charitable, educational, or scientific institution, or governmental entity operating exclusively for charitable and educational purposes; have a demonstrated knowledge of trauma and trauma research; have demonstrated competence and capacity to execute the proposed work; and, if human participants are involved, have IRB approval from his/her host institution before funding can be awarded.

The 2017 Building Trust and Mutual Respect to Improve Health Care call for proposals (CFP) will fund empirical research studies to help us better understand how to build trust and mutual respect to meet vulnerable patients' health care needs. For this CFP, we would define vulnerable populations in a number of different ways, including the economically disadvantaged, diverse racial and ethnic populations, the uninsured, older adults, homeless individuals, and people with complex health and social needs (including people with acute behavioral health needs or multiple chronic conditions). Proposals most closely aligned with the scope of this CFP will go beyond documenting the problem to generate findings that will be generalizable and have broad application across health systems and the field. Eligibility and Selection Criteria · Researchers, as well as practitioners in the public and private sector working with researchers, are eligible to submit proposals through their organizations. Projects may be generated from disciplines including health services research; economics; sociology; program evaluation; political science; public policy; psychology; public health; public administration; law; business administration; or other related fields. · The Foundation may give preference to applicants that are either public entities or nonprofit organizations that are tax-exempt under Section 501(c)(3) of the Internal Revenue Code and are not private foundations or Type III supporting organizations. · The Foundation may require additional documentation. Applicant organizations must be based in the United States or its territories.

The Endowment Fund is especially interested in how technology may be used or adapted to monitor, manipulate, analyze, or model brain function at any level, from the molecular to the entire organism. Technology may take any form, from biochemical tools to instruments to software and mathematical approaches. Because the program seeks to advance and enlarge the range of technologies available to the neurosciences, research based primarily on existing techniques will not be considered.

Aimed at advancing cutting-edge investigations, the awards are presented to highly promising, early career scientists. At this critical juncture in young investigators' careers, when funding can be a challenge, the fellowship awards promote higher-risk, and potentially higher-reward, projects.

The Children's Heart Foundation's 2020 Call for Research Proposals is now open! The Children's Heart Foundation funds life-saving, life-changing congenital heart defect (CHD) research in clinical cardiology, translational research, population science, and advancement, prevention, detection of surgical and interventional techniques including, but not limited to the following areas:  Genetics Biochemistry Pharmacology Devices and procedural research (cardiac catheterization and surgery) Neurodevelopmental and functional outcomes Quality and policy regarding delivery of care, coverage, and access Maternal environment and modifiable disease impact on fetuses with CHD Fetal diagnosis and intervention Long-term care of adults with CHDs Technological development and advancements

The Children's Heart Foundation's 2020 Call for Research Proposals is now open! The Children's Heart Foundation funds life-saving, life-changing congenital heart defect (CHD) research in clinical cardiology, translational research, population science, and advancement, prevention, detection of surgical and interventional techniques including, but not limited to the following areas:  Genetics Biochemistry Pharmacology Devices and procedural research (cardiac catheterization and surgery) Neurodevelopmental and functional outcomes Quality and policy regarding delivery of care, coverage, and access Maternal environment and modifiable disease impact on fetuses with CHD Fetal diagnosis and intervention Long-term care of adults with CHDs Technological development and advancements

This Funding Opportunity Announcement (FOA) utilizes the Small Business Innovation Research Program (SBIR) award mechanism to support the development of highly engaging cognitive training interventions delivered through computers and/or gaming platforms that are targeted to the treatment of neuropsychiatric disorders, autism and/or HIV Associated Neurocognitive Disorders (HAND), with the goal of improving real-world functioning of patients. This initiative specifically supports small businesses with development and commercial experience in the entertainment software industry to partner with clinical neuroscientists experienced with cognitive training.

The Neuroscience Scholars Program (NSP) is a three-year fellowship administered by the Society for Neuroscience to enhance career development and professional networking opportunities for underrepresented diverse undergraduate and graduate students, and postdoctoral fellows in neuroscience. The program, funded by the National Institute of Neurological Disorders and Stroke, provides scholars with: Annual stipend for enrichment activities outside the scholar's home institution Support for and annual meeting travel expenses Access to annual meeting workshops, courses, and events Complimentary SfN meeting registration and abstract fee waivers Complimentary SfN membership and subscription to The Journal of Neuroscience online Mentoring Other benefits include opportunities to network, expand professional contacts, and acquire professional skills.

The National Niemann-Pick Disease Foundation (NNPDF) invites applications for postdoctoral research fellowships examining the biology of Niemann-Pick Type C (NPC) disease, a lethal neurodegenerative disease for which there are no effective therapies. M.D., Ph. D. and D.V.M. postdoctoral fellows are eligible to apply for funding to improve our understanding of the biology and pathogenesis of NPC disease.  Preference will be given to research projects developing new therapies for NPC and identifying biomarkers of disease activity for diagnosis and clinical trials. The fellowships provide support of $50,000 per annum for two years and may be renewable based on performance.  Applicants must be currently associated with a recognized laboratory

The purpose of this FOA is to seek, identify and support bold and innovative approaches to broaden graduate and postdoctoral training, such that training programs reflect the range of career options that trainees (regardless of funding source) ultimately may pursue and that are required for a robust biomedical, behavioral, social and clinical research enterprise. Collaborations with non-academic partners are encouraged to ensure that experts from a broad spectrum of research and research-related careers contribute to coursework, rotations, internships or other forms of exposure. This program will establish a new paradigm for graduate and postdoctoral training; awardee institutions will work together to define needs and share best practices.

The Encyclopedia of DNA Elements (ENCODE) project, by systematically cataloging transcribed regions, transcription factor binding sites, and chromatin structure, has recently found that a larger fraction of the human genome may be functional than was previously appreciated. However, our understanding of the role of these functional genomic elements in neurodevelopment and mental disorders is at an early stage. This funding opportunity will support studies that identify non-coding functional genomic elements and elucidate their role in the etiology of mental disorders.

This Funding Opportunity Announcement (FOA) encourages research grant applications from institutions/organizations to investigate mechanisms by which the gut microbiome modulates the development and function of brain circuits that subserve behavioral functions of direct relevance to the mission of the NIMH.Because initial colonization of the gut by microbiota occurs early in life and may influence the subsequent development and modifiability of the central nervous system, developmental studies are of particular interest. Applicants may propose to use wild-type, gnotobiotic, or specific pathogen-free model organisms and/or human cohorts. With this FOA, the NIMH encourages investigator teams to initiate hypothesis-driven research in this cross-cutting research area and to identify promising mechanistic leads for future basic and translational research that will advance the mission of the NIMH.

The BDSRA is pleased to announce that funds are available to conduct research directly relevant to all forms of Neuronal Ceroid Lipofuscinosis (NCL, Batten disease), rare, fatal, lysosomal neurodegenerative disorders that strike infants, children and adults. Research is needed across a broad spectrum addressing the underlying mechanisms of neural dysfunction and degeneration in each form of NCL from dysfunctional soluble lysosomal enzymes (PPT1, TPP1, CTSD), transmembrane proteins (CLN3, CLN6, MFSD8, CLN8) and other proteins implicated in lysosome function, membrane trafficking, or neurotransmitter release (CLN5, CSPα). Proposals will be considered for all forms of NCL, with emphasis on CLN1, CLN2, and CLN3. 

This funding opportunity announcement (FOA) issued by ORIP, National Institutes of Health, encourages research grant applications from institutions/organizations that propose to develop, characterize or improve animal models for human disease or to improve diagnosis and control of diseases that might interfere with animal use for biomedical research purposes.

This Funding Opportunity Announcement (FOA) issued by the National Institute of Mental Health (NIMH) seeks research studies that use dimensional constructs to integrate biology (e.g., brain circuit o

The purpose of this funding opportunity announcement is to request applications for the initiation or continuation of nationally-available neuroscience research education programs that will significantly advance the mission of NINDS.

The purpose of this Dear Colleague Letter is to advise you about funding opportunities at the National Science Foundation for the research community to propose research projects or workshops that will gather data on the implementation and impacts of recent science policy initiatives including, but not limited to those noted earlier.  Especially encouraged are proposals that will: Develop new, or improve existing, analytical frameworks for evaluating the impacts of federal science policy initiatives; Explore different agencies' approaches to the implementation of particular policies to examine how variations in approach affect the achievement of intended policy outcomes; Collect case-study or quantitative data that facilitate identification of best practices in science and innovation policy implementation.

The Social Psychology Program at NSF supports basic research on human social behavior, including cultural differences and development over the life span.  Among the many research topics supported are: attitude formation and change, social cognition, personality processes, interpersonal relations and group processes, the self, emotion, social comparison and social influence, and the psychophysiological and neurophysiological bases of social behavior.  The scientific merit of a proposal depends on four important factors: (1) The problems investigated must be theoretically grounded. (2) The research should be based on empirical observation or be subject to empirical validation. (3) The research design must be appropriate to the questions asked. (4) The proposed research must advance basic understanding of social behavior.

The Linguistics Program supports basic science in the domain of human language, encompassing investigations of the grammatical properties of individual human languages, and of natural language in general. Research areas include syntax, semantics, morphology, phonetics, and phonology. The program encourages projects that are interdisciplinary in methodological or theoretical perspective, and that address questions that cross disciplinary boundaries, such as (but not limited to): What are the psychological processes involved in the production, perception, and comprehension of language? What are the computational properties of language and/or the language processor that make fluent production, incremental comprehension or rapid learning possible? How do the acoustic and physiological properties of speech inform our theories of language and/or language processing? What role does human neurobiology play in shaping the various components of our linguistic capacities? How does language develop in children? What social and cultural factors underlie language variation and change?