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The purpose of this Funding Opportunity Announcement (FOA) is to support intramural-extramural collaborations to develop and implement the use of 3D biofabricated tissue models as novel drug screening platforms and advance pre-clinical discovery and development of non-addictive treatments for nociception, opioid use disorder (OUD) and/or overdose. In particular, support during the UH2 phase is for the application of 3D biofabrication technologies to develop novel multicellular tissue constructs for drug screening by using human iPSC-derived cells representing sensory/pain neurons, brain regions, and other tissues involved in nociception, addiction and/or overdose, including tissue models of the blood-brain barrier (BBB). Support during the UH3 is for implementation of drug screens using the 3D tissue models developed during the UH2 phase. Please limit this field to a brief description of to page in length. Brevity is appreciated. This FOA is part of the of the NIHs Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative will bolster research across NIH to (1) improve treatment for opioid misuse and addiction and (2) enhance pain management. More information about the HEAL Initiative is available at: https://www.nih.gov/research-training/medical-research-initiatives/heal-initiative

The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational activities and clinical trials to treat pain with innovative, targeted, and non-addictive diagnostic and/or therapeutic devices that improve patient outcomes and decrease or eliminate the need to prescribe opioids. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, as well as a subsequent small clinical trial (e.g., Early Feasibility Study). The clinical trial is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in the development of the project plan and monitoring of research progress. This FOA will leverage Public-Private Partnership Programs (PPP) initiated under the NIH BRAIN Initiative, the Office of Strategic Coordination The Common Funds Stimulating Peripheral Activity to Relieve Conditions (SPARC) Program, and the HEAL Initiative. These programs include agreements (Memoranda of Understanding, MOU) with a number of device manufacturers willing to make such devices available, including devices and capabilities not yet market approved but appropriate for clinical research. In general, it is expected that the devices' existing safety and utility data will be sufficient to enable new IRB NSR or FDA IDE approval without the need for significant additional non-clinical data.

The PRP EIRA supports Parkinson's disease-focused research opportunities for individuals in the early stages of their careers, under the guidance of a designated Mentor. The Early Investigator is considered the Principal Investigator (PI) of the application and must exhibit strong potential for, and commitment to, pursuing a career as an investigator at the forefront of Parkinson's disease research; however, the PI is not required to have previous Parkinson's disease research experience. Applications must include at least one Mentor, appropriate to the proposed research project, who has experience in Parkinson's disease research and mentoring as demonstrated by a record of active funding, recent publications, and successful mentorship. The selected Mentor(s) should also demonstrate a clear commitment to the development of the PI toward independence as a Parkinson's disease researcher.

The PRP EIRA supports Parkinson's disease-focused research opportunities for individuals in the early stages of their careers, under the guidance of a designated Mentor. The Early Investigator is considered the Principal Investigator (PI) of the application and must exhibit strong potential for, and commitment to, pursuing a career as an investigator at the forefront of Parkinson's disease research; however, the PI is not required to have previous Parkinson's disease research experience. Applications must include at least one Mentor, appropriate to the proposed research project, who has experience in Parkinson's disease research and mentoring as demonstrated by a record of active funding, recent publications, and successful mentorship. The selected Mentor(s) should also demonstrate a clear commitment to the development of the PI toward independence as a Parkinson's disease researchers

The Society for Neuroscience works to advance understanding of the brain and nervous system, support scientific exchange and the neuroscience community, educate and engage the public, and advocate for the field. To that end, the society is accepting applications for its Young Investigator Award, which recognizes the outstanding achievements and contributions of a young neuroscientist who demonstrates scholarly independence. The recipients will receive a $15,000 award as well as complementary registration, transportation, and hotel accommodations for the SFN annual meeting.

The American Association for Cancer Research is accepting applications for its AACR NextGen Grants for Transformative Cancer Research program. The annual program is designed to stimulate highly innovative research from young investigators. Three-year grants of up to $450,000 will be awarded in support of creative, paradigm-shifting cancer research that might not be funded through conventional channels. The funds are intended to support expenses related to the research project, which may include salary and benefits of the grant recipient, postdoctoral or clinical research fellows, graduate students (including tuition costs), and research assistants; research/laboratory supplies and equipment; travel applicable to the research project; publication charges for manuscripts that pertain directly to the funded project; and other research expenses and indirect costs. Research projects must represent a highly innovative approach to a major contemporary challenge in cancer research. The research, which can be in any area of basic, translational or clinical science, must have the potential to lead to groundbreaking discoveries in the field and transform our understanding of the tumorigenesis process and/or ability to treat, detect, or prevent cancer. To be eligible, applicants must have a doctoral degree in a related field and not currently be a candidate for a further doctoral degree. In addition, at the start of the grant term on July 1, 2018, applicants must hold a tenure-eligible appointment at the level of assistant professor; have held this appointment for no more than three years; and work at an academic, medical, or research institution anywhere in the world. AACR membership is required.

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is aimed at revolutionizing neuroscience through development and application of innovative technologies to map neural circuits, monitor and modulate their activity, and understand how they contribute to thoughts, sensations, emotions and behavior. NIH has issued a variety of Funding Opportunity Announcements (FOAs) that will support projects that apply technologies to understand neural circuit function in the context of specific circuits, resulting in a diverse portfolio of research into the fundamental biology of nervous system function. The purpose of this announcement is to notify the research community that NIH welcomes BRAIN Initiative applications targeting central nervous system nociceptive and pain circuits, as appropriate to the goals and requirements of specific BRAIN Initiative FOAs. Pain conditions represent an important public health problem and NIH continues to support research into pain pathologies through normal Institute and Center appropriations. However, pain and nociception are also components of normal nervous system function, and the BRAIN Initiative is committed to understanding pain circuits along with brain circuits underlying other sensory, motor, cognitive and emotional functions. It is expected that the unique opportunities of the BRAIN Initiative will enable production of detailed maps of pain circuits, and the adoption of powerful new tools for monitoring and modulating pain circuit activity, leading to significant advances in the understanding of pain and nociception. For a list of past and open BRAIN Initiative FOAs, see https://braininitiative.nih.gov/funding/.

Rotary International is accepting applications for its CART Fund, a program designed to encourage exploratory and developmental Alzheimer's disease research projects within the United States. To that end, the fund will award grants of up to $250,000 to support for early and conceptual plans of those projects that may not yet be supported by extensive preliminary data but have the potential to substantially advance biomedical research. These projects should be new and distinct from those designed to increase knowledge in a well-established area unless they intend to extend previous discoveries toward new directions or applications. Eligible applications may come from full time faculty (or equivalent status) at U.S.-based public and private institutions, such as universities, colleges, hospitals, and laboratories.

Alex's Lemonade Stand Foundation, a nonprofit foundation that has evolved from a young cancer patient's front yard lemonade stand to a national foundation for childhood cancer, awards grants designed to fill critical voids in current pediatric cancer research. Through its Innovation Grants program, the foundation awards two-year grants of up to $250,000 in support of researchers with a novel approach to pediatric oncology investigation. This can include a change in research direction and/or an innovative new idea that moves away from an investigator's prior research but has potential impact for childhood cancers. Innovation Grants will support research proposals to be carried out by investigators who are already established, have a track record of peer-reviewed publications, and can demonstrate evidence of successfully competing for extramural funding. To be eligible, applicants must possess a degree at the MD, MD/PhD or PhD level and hold a faculty appointment at an academic institution.

The Adolescent Brain Cognitive Development (ABCD) Study is collecting data on health and mental health, cognitive function, substance use, cultural and environmental factors, and brain structure and function from youth starting when they are 9-10 years-old repeatedly for 10 years and makes that data available to the scientific community through the NIMH Data Archive. The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications proposing the analysis of this public use dataset to increase knowledge of adolescent health and development. More information about the ABCD Study may be found on the ABCD Study web page (www.abcdstudy.org).

The Adolescent Brain Cognitive Development (ABCD) Study is collecting data on health and mental health, cognitive function, substance use, cultural and environmental factors, and brain structure and function from youth starting when they are 9-10 years-old repeatedly for 10 years and makes that data available to the scientific community through the NIMH Data Archive. The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications proposing the analysis of this public use dataset to increase knowledge of adolescent health and development. More information about the ABCD Study may be found on the ABCD Study web page (www.abcdstudy.org).

The Society for Neuroscience, the world's largest organization of scientists and physicians dedicated to understanding the brain and the nervous system, works to advance scientific exchange, support the neuroscience community, educate and engage the public, and advocate for the field. In support of this mission, SfN is accepting applications for the Swartz Prize for Theoretical and Computational Neuroscience. Supported by the Swartz Foundation, the prize honors an individual whose activities have produced a significant cumulative contribution to theoretical models or computational methods in neuroscience or who has made a particularly noteworthy recent advance in theoretical models or computational neuroscience.

The intent of the FY19 FITBIR Analysis Award is to leverage this data to identify actionable insights for the diagnosis, management, and treatment of TBI. The proposed research must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the American public. The anticipated total costs budgeted for the entire period of performance for an FY19 JPC-6/CCCRP PH/TBI FITBIR Analysis Award will not exceed $750,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. The JPC-6/CCCRP expects to allot approximately $3M of the FY19 PH/TBIRP appropriation to fund approximately 4 FITBIR Analysis Award applications. Funding of applications received is contingent upon the availability of Federal funds for this program as well as the number of applications received, the quality and merit of the applications as evaluated by scientific and programmatic review, and the requirements of the Government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY19 FITBIR Analysis Award funding opportunity will be funded with FY19 funds, which will expire for use on September 30, 2025

AFTD Basic Science Pilot Grants provide seed funding for innovative research projects that expand our understanding of the biology or pathophysiology of frontotemporal degeneration (FTD). The FTD disorders include: behavioral variant FTD, primary progressive aphasia, progressive supranuclear palsy, corticobasal syndrome, and FTD-ALS/MND. Applications are welcome from investigators at not-for-profit institutions or biotechnology startup organizations. Pilot Grant funded projects are intended to generate data that will support follow-on grant applications to the National Institutes of Health (NIH) or other public or private agencies.

The Albert Einstein Fellowship supports creative, interdisciplinary thought by giving young scholars the chance to pursue research outside their previous area of work. Candidates must be under 35 and hold a university degree in the humanities, in the social sciences, or in the natural sciences. Applications for 2019 should include a CV, a two-page project proposal, and two letters of recommendation. All documents must be received by April 15, 2018. At the end of the fellowship period, the fellow will be expected to present his or her project in a public lecture at the Einstein Forum and at the Daimler and Benz Foundation. The Einstein Fellowship is not intended for applicants who wish to complete an academic study they have already begun. A successful application must demonstrate the quality, originality, and feasibility of the proposed project, as well as the superior intellectual development of the applicant. It is not relevant whether the applicant has begun working toward, or currently holds, a PhD. The proposed project need not be entirely completed during the time of the fellowship, but can be the beginning of a longer project. PLEASE NOTE THAT NO FELLOWSHIPS WILL BE GIVEN FOR DISSERTATION RESEARCH. THE PROPOSED PROJECT MUST BE SIGNIFICANTLY DIFFERENT IN CONTENT, AND PREFERABLY FIELD AND FORM, FROM THE APPLICANT'S PREVIOUS WORK.

NYSCF is soliciting applications from early career investigators for Innovator awards in neuroscience. The goal of this initiative is to foster truly bold, innovative scientists with the potential to transform the field of neuroscience. Applicants are encouraged in the fundamental areas of developmental, cellular, cognitive, and translational neuroscience, broadly interpreted. Applicants need not be working in areas related to stem cells. The award provides $1.5M USD over 5 years and is open to researchers based at both national and international accredited academic and nonprofit research institutions. To be eligible, candidates must: - Have completed one or more of the following degrees: MD, PhD, DPhil - Be within 5 years of starting a faculty (professorship) or comparable position on June 1, 2018 - Have demonstrated ability to independently supervise staff and research - Have a publication record containing articles that are innovative and high impact

The Eppley Foundation supports advanced, novel, scientific research by PhDs or MDs with an established record of publication in their specialties. The Foundation does not support work in the social sciences, education or computer science, and only rarely funds research into diseases that have considerable financial support available, such as AIDS, diabetes, cancer and heart disease. Particular areas of interest include innovative medical investigations, climate change, whole ecosystem studies, as well as research on single species if they are of particular significance in their environments, in the U.S. and abroad. The Foundation does not fund work that can qualify for funding from conventional sources such as the National Science Foundation or the National Institutes of Health, or similar agencies at the state level. It is important to the Foundation that the work proposed be novel in its insights and unlikely to be underway elsewhere. The Foundation is prepared to take risks.

This FOA invites applications from qualified institutions to create a Roybal Center Coordinating Center (CC), serving the needs of the Roybal Centers for Translational Research on Aging program as well as the Roybal Centers for Translational Research on Dementia Care Provider Support program. The Roybal Coordinating Center will serve as a hub for the Roybal Center grant program. Roybal Center programs conduct translational in the behavioral and social sciences of aging, structured in accordance with the NIH Stage Model. Roybal Center program resources are intended for pilot and preliminary translational, multi-directional research at Stages 0 through IV of the behavioral intervention development pipeline with the goal of creating principle-driven interventions that improve the lives of mid-life and older people and the capacity of institutions to adapt to societal aging. The Roybal Coordinating Center will facilitate and coordinate trans-Roybal activities. The Center will work closely with the NIA Program Officer and, in coordination with all Roybal sites, will be responsive to requests generated by key Roybal site personnel, NIA, NIH, the scientific community, and the general public.

The goal of this FOA is to support short courses geared to behavioral and social scientists who have existing expertise in aging research and can make research contributions in Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) with additional knowledge about the disease and related research resources. Fields of behavioral and social science research relevant for this FOA are health economics, labor economics, health services research, healthcare policy, public policy, demography, sociology, social epidemiology, psychology, and social neuroscience. Priority areas of focus include, but are not limited to, the following: dementia care; dementia caregiver research; cognitive and dementia epidemiology; behavioral and social pathways of AD/ADRD; role of social, contextual, environmental, and institutional factors in AD/ADRD; early psychological changes preceding AD/ADRD onset; prevention of AD/ADRD; disparities in AD/ADRD or dementia-related outcomes; and research resources and methods for studying the determinants and impact of AD/ADRD.

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing the innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of drug using behaviors (defined as alcohol, tobacco, prescription and other drug) and related disorders, prevention of drug use and HIV, and health service utilization. This FOA encourages the analyses of public use and other extant community-based or clinical datasets to their full potential in order to increase our knowledge of etiology, trajectories of drug using behaviors and their consequences including morbidity and mortality, risk and resilience in the development of psychopathology, strategies to guide the development, testing, implementation, and delivery of high quality, effective and efficient services for the prevention and treatment of drug abuse and HIV.