RFA-EY-15-002: NEI Audacious Goal Initiative: Discovery-based Science to Identify facto... - 0 views
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MiamiOH OARS on 26 Aug 15The NEI Audacious Goal Initiative (AGI; see https://www.nei.nih.gov/audacious) is to restore vision through regeneration of neurons and neural connections in the eye and visual system. Recent advances have identified molecules and signaling pathways that can either promote or inhibit regeneration of neurons in the visual pathway. These advances have led to significant axon growth in mouse optic-nerve crush and other regeneration models. The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing to use discovery-based approaches to identify unknown factors critical to the regeneration of neurons, guiding their axons to targets, and making new functional connections. Future FOAs will focus on understanding the biological mechanisms through which these factors influence regeneration.