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Tero Toivanen

AP Bio- Physiology 7: Neurons by David Knuffke on Prezi - 0 views

prezi.com/...ap-bio-physiology-7-neurons

physiology neurons neuron brain prezi presentation

shared by Tero Toivanen on 23 Sep 12 - No Cached
  • Tero Toivanen on 23 Sep 12
     
    Great presentation about neurons.
Tero Toivanen

YouTube - Music and the Mind - 0 views

www.youtube.com/watch

brain music stroke language science presentation amusia aphasia

shared by Tero Toivanen on 13 Jul 09 - Cached
  • Tero Toivanen on 13 Jul 09
     
    Aniruddh Patel's presentation about: What can music teach us about the brain? What can brain science teach us about music?
Tero Toivanen

YouTube - Man without a memory - Clive Wearing [BBC - Time: Daytime] - 3 views

www.youtube.com/watch

youtube neuropsychology memory present moment

shared by Tero Toivanen on 03 Jan 10 - Cached
Ruth Howard liked it
  • Tero Toivanen on 03 Jan 10
     
    Man who don't have memory and is constantly living in the present moment.
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  • Ruth Howard on 04 Jan 10
     
    I love that ' bump up against' people and ideas counter to those which we' ve previously aligned-that' s kind of how I see aging gracefully-being able to see many more and others viewpoints-otherwise aging can seem like becoming caricatures of ourselves-we so believe our own thoughts (beliefs are after all only our much/most repeated thoughts!) and there' s no room for anyone or anything else! Mmmmmm yeah but now to live it!
  • Tero Toivanen on 04 Jan 10
     
    My mother had a stroke and now she has big problems to communicate. She understands allmost everything, but have great problems to express herself speaking. Aging is not easy thing if you have problems with your health.
  • Ruth Howard on 05 Jan 10
     
    Truly! It' s alot slower to align with our preferences for sure when sick. I sincerely recommend www.bruno-groening.org as a resource The Bruno Groning Circle of Friends-all volunteers!. It' s a type of Faith healing that I recognise as quite remarkable. It has strong old world Germanic Christian vibe and/but dont let that put you off the ' healing stream' which is very easy to teach to yourself/your mother and available to all regardless of religious affliations.
  • Tero Toivanen on 05 Jan 10
     
    Thak you for the link : )
David McGavock

How Did Consciousness Evolve? - The Atlantic - 0 views

www.theatlantic.com/...485558

research Consciousness Evolution

shared by David McGavock on 12 Jun 16 - No Cached
  • consciousness, is rarely studied in the context of evolution.
  • What is the adaptive value of consciousness? When did it evolve and what animals have it?
  • Attention Schema Theory (AST),
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  • suggests that consciousness arises as a solution to one of the most fundamental problems facing any nervous system: Too much information constantly flows in to be fully processed. The brain evolved increasingly sophisticated mechanisms for deeply processing a few select signals at the expense of others,
  • The next evolutionary advance was a centralized controller for attention that could coordinate among all senses. In many animals, that central controller is a brain area called the tectum
  • It coordinates something called overt attention
  • The tectum is a beautiful piece of engineering. To control the head and the eyes efficiently, it constructs something called an internal model, a feature well known to engineers. An internal model is a simulation that keeps track of whatever is being controlled and allows for predictions and planning.
  • With the evolution of reptiles around 350 to 300 million years ago, a new brain structure began to emerge – the wulst
  • our version is usually called the cerebral cortex and has expanded enormously
  • The cortex is like an upgraded tectum
  • The most important difference between the cortex and the tectum may be the kind of attention they control
  • tectum is the master of overt attention—pointing the sensory apparatus toward anything important
  • cortex ups the ante with something called covert attention
  • Your cortex can shift covert attention from the text in front of you to a nearby person, to the sounds in your backyard, to a thought or a memory. Covert attention is the virtual movement of deep processing from one item to another.
  • the cortex must model something much more abstract.
  • it does so by constructing an attention schema
  • a constantly updated set of information that describes what covert attention is doing moment-by-moment and what its consequences are
  • The attention schema is therefore strategically vague. It depicts covert attention in a physically incoherent way, as a non-physical essence. And this, according to the theory, is the origin of consciousness. We say we have consciousness because deep in the brain, something quite primitive is computing that semi-magical self-description.
  • In the AST, the attention schema first evolved as a model of one’s own covert attention. But once the basic mechanism was in place, according to the theory, it was further adapted to model the attentional states of others, to allow for social prediction
  • theory of mind, the ability to understand the possible contents of someone else’s mind.
  • Language is perhaps the most recent big leap in the evolution of consciousness. Nobody knows when human language first evolved. Certainly we had it by 70 thousand years ago when people began to disperse around the world, since all dispersed groups have a sophisticated language.
  • Maybe partly because of language and culture, humans have a hair-trigger tendency to attribute consciousness to everything around us.
  • Justin Barrett called it the Hyperactive Agency Detection Device, or HADD
  • David McGavock on 12 Jun 16
     
    The Attention Schema Theory (AST), developed over the past five years, may be able to answer those questions. The theory suggests that consciousness arises as a solution to one of the most fundamental problems facing any nervous system: Too much information constantly flows in to be fully processed. The brain evolved increasingly sophisticated mechanisms for deeply processing a few select signals at the expense of others, and in the AST, consciousness is the ultimate result of that evolutionary sequence. If the theory is right-and that has yet to be determined-then consciousness evolved gradually over the past half billion years and is present in a range of vertebrate species.
Tero Toivanen

Eide Neurolearning Blog: Why Boys Need Alternatives with Reading and Writing - 0 views

eideneurolearningblog.blogspot.com/...alternatives-with-reading.html

neurolearning Reading and Writing brain

shared by Tero Toivanen on 23 May 09 - Cached
  • If you give girls and boys language tasks, most girls will process the information in the same way (in a specialized language area)
  • help them with word storage and retrieval
  • But for boys, sensitivity to the modality of how words are presented means that an extra steps need to be taken to match words that are picked up by listening and words that are read on the printed page. No wonder dyslexia is much more common in boys - the separate system means that the sight and sound of words are learned as distinct processes.
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  • As a result, verbal competence may be strong in one domain (oral speech for instance), but be weak in another (reading).
  • because boys require two areas and a matching of visual-auditory inputs, impairment in one system may cause the whole language coordination process to fail.
  • The visual-auditory gap may also be why some boys may need to read word-for-word outloud or to themselves (i.e. not silently read) in order to fully comprehend or remember the story.
  • Some careful consideration needs to made of instructional implications for boys given some of these new discoveries. Learning by listening and learning by reading are not synonymous; route-congruent factors(listening - oral presentation, reading - written response) may need to be considered when a learning gap or frank underachievement is seen, and an insistence on the availability of auditory-visual supports (reading along with books-on-tape, detailed handouts for lecture courses) should be a requirement of every classroom.
  • Tero Toivanen on 23 May 09
     
    Boys require two areas and a matching of visual-auditory inputs, impairment in one system may cause the whole language coordination process to fail.
Tero Toivanen

Phasic Firing Of Dopamine Neurons Is Key To Brain's Prediction Of Rewards - 0 views

www.sciencedaily.com/...090403144032.htm

dopamine neurons brain learning rewards behavior

shared by Tero Toivanen on 23 May 09 - Cached
  • Our research findings provide a direct functional link between the bursting activity of midbrain dopamine neurons and behavior. The research has significant applications for the improvement of health, because the dopamine neurons we are studying are the same neurons that become inactivated during Parkinson's Disease and with the consumption of psychostimulants such as cocaine and amphetamine
  • Midbrain dopamine neurons fire in two characteristic modes, tonic and phasic, which are thought to modulate distinct aspects of behavior. When an unexpected reward is presented to an individual, midbrain dopamine neurons fire high frequency bursts of electrical activity. Those bursts of activity allow us to learn to associate the reward with cues in our environment, which may predict similar rewards in the future.
  • When researchers placed the mice in reward-based situations, they found that the mice without the NMDA receptor in their dopaminergic neurons could not learn tasks that required them to associate sensory cues with reward. Those same mice, however, were able to learn tasks that did not involve an association with rewards.
Tero Toivanen

AK's Rambling Thoughts: Nerve Cells and Glial Cells: Redefining the Foundation of Intel... - 0 views

artksthoughts.blogspot.com/...nd-glial-cells-redefining.html

brain Glial Cells neuron action potential axon synapse network microglia macroglia astrocytes oligodendrocytes ependymal cells radial glia

shared by Tero Toivanen on 25 Jun 09 - Cached
  • Glia are generally divided into two broad classes, microglia and macroglia. Microglia are part of the immune system, specialized macrophages, and probably don't participate in information handling. Macroglia are present in both the peripheral and central nervous systems, in different types.
  • Traditionally, there were four types of glia in the CNS: astrocytes, oligodendrocytes, ependymal cells, and radial glia. Of these, the one type that's most important to the developing revolution in our ideas are those cells called astrocytes.2 It turns out that there are at least two types of cell (at least) subsumed under this name.24, 25, 31, 32 One, which retains the name of astrocyte, takes up neurotransmitters released by neurons (and glial cells), aids in osmoregulation,10 controls circulation in the brain,1, 31 and generally appears to provide support for the neurons and other types of glia.
  • Although both NG2-glia and astrocytes extend processes to nodes of Ranvier in white matter ([refs]) and synapses in grey matter, their geometric relationship to these neuronal elements is different. Thus, although astrocytes and NG2-glia bear a superficial resemblance, they are distinguished by their different process arborizations. This will reflect fundamental differences in the way these two glial cell populations interact with other elements in the neural network.
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  • Both types of glia are closely integrated with the nervous system, receiving information from action potentials via synapses22 (which, only a few years ago were thought to be limited to neurons), and returning control of neuron activity through release of neurotransmitters and other modulators. Both, then, demonstrate the potential for considerable intelligent activity, contributing to the overall intelligence of the brain.
  • Astrocytes probably (IMO) are limited, or mostly so, to maintaining the supplies of energy and necessary metabolites. They receive action potentials,3, 6 which allows them to closely and quickly monitor general activity and increase circulation in response, even before the neurons and NG2-glia have reduced their supply of ATP.21 They appear to be linked in a network among themselves,2, 5 allowing them to communicate their needs without interfering with the higher-level calculations of the brain.
  • NG2-glia appear to have several functions, but one of the most exciting things about them is that they seem to be able to fire action potentials.33 Their cell membranes, like those of the dendrites of neurons, have all the necessary channels and receptors to perform real-time electrical calculations in the same way as neural dendrites. They have also demonstrated the ability to learn through long term potentiation.
  • Dividing NG2-glia also retain the ability to fire action potentials, as well as receiving synaptic inputs from neurons.23 Presumably, they continue to perform their full function, including retaining any elements of long term potentiation or depression contained in their synapses.
  • Oligodendrocytes are responsible for the insulation of the axons, wrapping around approximately 1 mm of each of up to 50 axons within their reach, and forming the myelin sheath.
  • Although the precise type of neuron formed by maturing cells hasn't been determined, the very fact that cells of this type can change into neurons is very important. We actually don't know whether the cells that do this maturation are the same as those that perform neuron-like activities, there appear to be two separate types of NG2-glia, spiking and non-spiking.26 It may very well be that the "spiking" type have actually differentiated, while the "non-spiking" type may be doing the maturing. Of course, very few differentiated cell types remain capable of division, as even the "spiking" type do.
  • What's important about both dendrites and NG2-glia isn't so much their ability to propagate action potentials, as that their entire cell membranes are capable of "intelligent" manipulation of the voltage across it.
  • While there are many ion channels involved in controlling the voltage across the cell membrane, the only type we really need to worry about for action potentials is voltage-gated sodium channels. These are channels that sometimes allow sodium ions to pass through the cell membrane, which they will do because the concentration of sodium ions outside the cell is very much higher than inside. When and how much they open depends, among other things, on the voltage across the membrane.
  • A normal neuron will have a voltage of around -60 to -80mV (millivolts), in a direction that tends to push the sodium ions (which are positive) into the cell (the same direction as the concentration is pushing). When the voltage falls to around -55mV, the primary type of gate will open for a millisecond or so, after which it will close and rest for several milliseconds. It won't be able to open again until the voltage is somewhere between -55 and around -10mV. Meanwhile, the sodium current has caused the voltage to swing past zero to around +20mV.
  • When one part of the cell membrane is "depolarized" in this fashion, the voltage near it is also depressed. Thus, if the voltage is at zero at one point, it might be at -20mV 10 microns (μm) away, and -40mV 20μm away, and -60mV 30μm, and so on. Notice that somewhere between 20μm and 30μm, it has passed the threshold for the ion channels, which means that they are open, allowing a current that drives the voltage further down. This will produce a wave of voltage drop along the membrane, which is what the action potential is.
  • After the action potential has passed, and the gates have closed (see above), the voltage is recovered by diffusion of ions towards and away from the membrane, the opening of other gates (primarily potassium), and a set of pumps that push the ions back to their resting state. These pumps are mostly powered by the sodium gradient, except for the sodium/potassium pump that maintains it, which is powered by ATP.
  • the vast majority of calculation that goes into human intelligence takes place at the level of the network of dendrites and NG2-glia, with the whole system of axons, dendrites, and action potentials only carrying a tiny subset of the total information over long distances. This is especially important considering that the human brain has a much higher proportion of glial matter than our relatives.
  • This, in turn, suggests that our overall approach to understanding the brain has been far too axon centric, there needs to be a shift to a more membrane-centric approach to understanding how the brain creates intelligence.
  • Tero Toivanen on 25 Jun 09
     
    Our traditional idea of how the brain works is based on the neuron: it fires action potentials, which travel along the axon and, when the reach the synapses, the receiving neuron performs a calculation that results in the decision when (or whether) to fire its own action potential. Thus, the brain, from a thinking point of view, is viewed as a network of neurons each performing its own calculation. This view, which I'm going to call the axon-centric view, is simplistic in many ways, and two recent papers add to it, pointing up the ways in which the glial cells of the brain participate in ongoing calculation as well as performing their more traditional support functions.
Tero Toivanen

Psychology Today: Flavonoids: Antioxidants Help the Mind - 0 views

www.psychologytoday.com/...pto-20030708-000001.html

flavonoids

shared by Tero Toivanen on 23 May 09 - Cached
  • ApplesQuercetin is the flavonoid that enables apples to keep the doctor away. Quercetin has been shown to reduce cancer risk, prevent heart attacks, stave off cataracts, control asthma, prevent recurrent gout attacks, and speed healing from acid reflux. Green TeaGreen tea contains, among others, the cancer-fighting flavonoid epigallocatechin gallate (ECGC). ECGC is unique in that it seems to battle cancer at all stages, from thwarting chemical carcinogens, to suppressing the spread of tumors. ECGC is as much as 100 times more powerful an antioxidant as vitamin C, and 25 times more powerful than vitamin E. ECGC also may account for the antibacterial properties of green tea. ChocolateChocolate contains many of the same flavonoids found in tea. The darker the chocolate, the more flavonoids present. Cocoa powder is the richest source by weight, and to maximize your benefits, make your hot chocolate from scratch. Homemade hot chocolate will provide you with more flavonoids than a store-bought mix. Red WineFlavonoids are the source of the well-known "French Paradox"—the ability of the French to consume lots of fat-laden cheese without dropping like flies from heart attacks. The red wine they enjoy is flavonoid-rich, which lowers their risk of heart disease. And if you're not a drinker, you can get almost all the same benefits from purple grape juice.
  • Tero Toivanen on 23 May 09
     
    Flavonoids: Antioxidants Help the Mind Naturally occurring plant pigments, flavonoids are one of the reasons fruits and vegetables are so good for you. Among the many benefits attributed to flavonoids are reduced risk of cancer, heart disease, asthma, and stroke. Apples, Green Tea, Chocolate and Red Wine
Tero Toivanen

New Light On Nature Of Broca's Area: Rare Procedure Documents How Human Brain Computes ... - 0 views

www.sciencedaily.com/...091015141500.htm

brain Broca's area Wernicke's area language cerebral cortex Sahin

shared by Tero Toivanen on 17 Oct 09 - Cached
  • The study – which provides a picture of language processing in the brain with unprecedented clarity – will be published in the October 16 issue of the journal Science.
  • "Two central mysteries of human brain function are addressed in this study: one, the way in which higher cognitive processes such as language are implemented in the brain and, two, the nature of what is perhaps the best-known region of the cerebral cortex, called Broca's area," said first author Ned T. Sahin, PhD, post-doctoral fellow in the UCSD Department of Radiology and Harvard University Department of Psychology.
  • The study demonstrates that a small piece of the brain can compute three different things at different times – within a quarter of a second – and shows that Broca's area doesn't just do one thing when processing language.
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  • The procedure, called Intra-Cranial Electrophysiology (ICE), allowed the researchers to resolve brain activity related to language with spatial accuracy down to the millimeter and temporal accuracy down to the millisecond.
  • "We showed that distinct linguistic processes are computed within small regions of Broca's area, separated in time and partially overlapping in space," said Sahin. Specifically, the researchers found patterns of neuronal activity indicating lexical, grammatical and articulatory computations at roughly 200, 320 and 450 milliseconds after the target word was presented. These patterns were identical across nouns and verbs and consistent across patients.
  • Tero Toivanen on 17 Oct 09
     
    "Two central mysteries of human brain function are addressed in this study: one, the way in which higher cognitive processes such as language are implemented in the brain and, two, the nature of what is perhaps the best-known region of the cerebral cortex, called Broca's area," said first author Ned T. Sahin, PhD, post-doctoral fellow in the UCSD Department of Radiology and Harvard University Department of Psychology.
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