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Intensive blood pressure lowering may similarly decrease cardiovascular events in both patients with and patients without type 2 diabetes mellitus, according to a study published online Dec. 6 in Diabetes Care. Tom F. Brouwer, M.D., from the University of Amsterdam, and colleagues assessed the effect of both type 2 diabetes and baseline cardiovascular disease risk on the treatment effect of intensive blood pressure lowering based on data and pooled analysis from two randomized trials (ACCORD-BP [Action to Control Cardiovascular Risk in Diabetes Blood Pressure]and SPRINT [Systolic Blood Pressure Intervention Trial] studies; total of 14,094 patients). The researchers found that the mean baseline systolic blood pressure was 139.5 mm Hg for the cohort and just over one-third (33.6 percent) had type 2 diabetes. The hazard ratio for the primary composite end point of unstable angina, myocardial infarction, acute heart failure, stroke, and cardiovascular death was 0.82 (P = 0.0017). There was a nonsignificant interaction between intensive blood pressure lowering and type 2 diabetes (P = 0.13). While the 10-year cardiovascular risk was higher in patients with type 2 diabetes, there was no interaction between the risk and treatment effect (P = 0.84).

For patients with stage 4 or 5 chronic kidney disease and hepatitis C virus (HCV) infection, 12 weeks of treatment with glecaprevir and pibrentasvir results in a high rate of sustained virologic response, according to a study published online Oct. 11 in the New England Journal of Medicine. Edward Gane, M.D., from Auckland City Hospital in New Zealand, and colleagues conducted a multicenter trial to examine the efficacy and safety of combination treatment with the NS3/4A protease inhibitor glecaprevir and the NS5A inhibitor pibrentasvir for 12 weeks in adults with HCV infection and compensated liver disease with severe renal impairment, dependence on dialysis, or both. Participants had stage 4 or 5 chronic kidney disease. One hundred four patients were enrolled in the trial. The researchers found that the sustained virologic response rate was 98 percent. During treatment, none of the patients had virologic failure, and none had a virologic relapse after the end of treatment. Pruritus, fatigue, and nausea were reported in at least 10 percent of the patients. Twenty-four percent of the patients reported serious adverse events. Because of adverse events, four patients discontinued the trial treatment prematurely; three of these had sustained virologic response

Mayo Clinic Hospital Medicine: Managing Complex Patients is organized by Mayo Clinic and would be held during Nov 08 - 11, 2017 at Loews Ventana Canyon Resort, Tucson, Arizona, United States Of America. The target audience for this medical event for inpatient care providers including physicians, nurse practitioners and physician assistants. Hospitalists are defined as those who spend most of their professional practice caring for hospitalized patients. This CME Conference has been approved with a maximum of 25.25 AMA PRA Category 1 Credits. Hospital Medicine is the fastest growing medical specialty and requires a diverse skill set. Hospital-based health care providers must be able to diagnose and manage a wide variety of clinical conditions, coordinate transitions of care, provide perioperative management to surgical patients and contribute to quality improvement and hospital administration. This program is specifically designed to ensure that participants augment their skill set to meet these many challenges in an effort to enhance the delivery of health care and provide better patient outcomes. Using an interactive, case-based format, key highlights from most major areas of hospital medicine will be presented. Conference Objectives are : * Classify a patient presenting with MI according to the most recent guidelines. * Select the appropriate indications for troponin testing. * Manage a patient with subsegmental pulmonary embolism. * Define sepsis according to the most recent clinical guidelines. * Select the appropriate antibiotics for a hospitalized patient with health-care associated pneumonia. * List strategies to improve the mobility of elderly patients in the hospital. * Manage a patient admitted to the hospital with diabetic ketoacidosis. * Recognize common sources of cognitive bias and heuristics to minimize their impact on patient care. * Order the appropriate tests for a hospitalized patient with a newly-diagnosed pleural effusion. * List novel the