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We describe how innate and adaptive immune cascades trigger the release of cytokines and chemokines, resulting in the initiation and progression of atherosclerosis. We discuss how cytokines have direct and indirect effects on myocardial function.

Unlike simple starvation, where body fat is lost preferentially, cancer cachexia is associated with depletion of both fat and skeletal muscle mass. Although anorexia is frequently associated with cachexia a reduction of nutrient intake alone could not explain the progressive wasting. Instead the process appears to be mediated by circulatory tumor-produced catabolic factors acting either alone or in concert with certain cytokines. A knowledge of the mechanisms involved should lead to the development of effective pharmacological intervention. Effective therapy should not only improve the quality of life of the cancer patient, but should lead to an increase in survival. Since cachexia is so common in cancer host products may be required for tumor homeostasis. Thus further knowledge in this area may lead to the development of new agents for the treatment of cancer.

J Lipid Res (2006), University of Kuopio, Finland

Raúl M. Grijalva (born February 19, 1948) has been U.S. Representative (D-AZ) since 2003. His father was a migrant worker from Mexico who entered the United States in 1945 through the Bracero Program and labored on southern Arizona ranches.

I've contributed a lot to this discussion.  Perhaps I've been obssessive.  I'm concerned about the state of healthcare in this country, though.  I'm upset about the rampant myths and lies being tossed around about healthcare reform.  I'm concerned about all the lazy thinking we citizens are exhibiting. Misinformation, misunderstandings, bias, prejudice, narrowly self-interested polemics, anger, manipulations, and nastiness are badly hurting the process (and probable outcome) of healthcare reform debates and efforts. I can't NOT write long, detailed comments when I read stuff that's...well...WHACK!