Skinner JS, Staiger DO, Fisher ES. Is technological change in medicine always worth it? The case of acute myocardial infarction. Health Aff (Millwood) 2006;25:w34-w47.
Atherosclerosis is the predominant underlying pathology of cardiovascular disease...atherosclerotic lesions are characterized by abundance of immune cells and their effector molecules, eventually leading to unstable angina, myocardial infarction, or strok
Generx (alferminogene tadenovec, Ad5FGF-4) from Cardium Therapeutics, which is in Phase III for myocardial ischaemia & angina. Darapladib from GSK inhibits lipoprotein-associated phospholipase A2 (Lp-PLA2).
We describe how innate and adaptive immune cascades trigger the release of cytokines and chemokines, resulting in the initiation and progression of atherosclerosis. We discuss how cytokines have direct and indirect effects on myocardial function.