If, say, the Nginx default page requires a transfer of 250 bytes to load, it means that if the servers are connected via a 100 Mbit/s link, the theoretical max RPS rate would be around 100,000,000 divided by 8 (bits per byte) divided by 250 => 100M/2000 = 50,000 RPS. Though that is a very optimistic calculation - protocol overhead will make the actual number a lot lower so in the case above I would start to get worried bandwidth was an issue if I saw I could push through max 30,000 RPS, or something like that.