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Organ transplants are needed by individuals whose organs have failed or are severely damaged and cannot be treated effectively by other medical therapies. Here are specific groups who may need an organ transplant: 1. Patients with End-Stage Organ Disease: Individuals with advanced, irreversible organ failure such as kidney, liver, heart, or lung failure. 2. Those with Severe Organ Damage: People who have suffered significant trauma or injury that severely damages an organ. 3. Individuals with Certain Genetic Conditions: Patients with genetic disorders that cause organ dysfunction or failure, such as polycystic kidney disease. 4. Chronic Infection Sufferers: People whose organs have been damaged by long-term infections, like chronic hepatitis leading to liver failure. 5. Cancer Patients: Individuals with cancers confined to one organ that cannot be adequately treated with other methods, such as liver cancer. 6. Autoimmune Disease Patients: Those whose immune systems attack their own organs, such as in lupus or autoimmune hepatitis.