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So far, stem cell therapy has proven to be an effective and promising treatment for the damaged cardiovascular tissues or myocardial tissues. We had enough evidence of bone-marrow-derived mesenchymal stromal cells, including induced pluripotent stem cells to regenerate myocardial tissues and cure heart failure in the animals and also different clinical trials. Ever since animal models and clinical trials have been successful to showcase the efficacy of cell-based therapies, application of stem cells thereby is widespread in the clinical settings to treat the conditions of heart failure.