The NHS has secured a deal for 'Pembrolizumab' to treat women with triple-negative breast cancer.
Up to 1,600 women a year affected by high risk triple-negative breast cancer are set to benefit from the confidential deal struck by the NHS and the Merck Sharp
and Dohme's (MSD), manufacturer of Pembrolizumab.
Triple-negative breast cancer affects around 8,000 women a year - accounting for 15% of all breast cancer cases.
This will be the 25th breast cancer treatment fast-tracked to patients through funding from the Cancer Drugs Fund and the second treatment for triple negative breast
cancer to be introduced this year on the NHS.
NHS chief executive, Amanda Pritchard, said: "This is a hugely significant moment for women - the NHS has struck a new deal to roll out a potentially life-saving
drug for patients suffering with the most aggressive form of breast cancer that has been traditionally very difficult to treat.
The National Institute for Health and Care Excellence (NICE) has recommended pembrolizumab in combination with chemotherapy (paclitaxel or nab-paclitaxel)
which is said to benefit people with triple negative breast cancer.
Clinical trial evidence shows that, compared with paclitaxel, pembrolizumab combination increases how long people have before their cancer gets worse and how long they live.
NICE already recommends atezolizumab in combination with chemotherapy for untreated PD-L1-positive, locally advanced or metastatic, triple-negative breast cancer.
Atezolizumab combination is recommended by NICE for people with IC equal to or greater than 1%.
"This means that some people who can't have atezolizumab combination could be eligible for pembrolizumab combination," said NICE.
NICE's independent appraisal committee also agreed that the pembrolizumab combination meets the higher cost-effectiveness threshold for life-extending treatments for people with a short life expectancy.
Given by injection every 3 weeks, pembrolizumab (also called Keytruda and made by Merck Sharp and Dohme) is a type of immunotherapy that specifically targets triple
negative breast cancer. It works by blocking the activity of a protein known as PD-L1 which is produced in larger amounts on cancerous cells than normal cells. By blocking PD-L1 it helps the person's own immune cells to attack the cancer.
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Palbace (known as IBRANCE in other parts of
the world) or palbociclib by Pfizer is a cancer drug that interferes with the growth and spread of cancer cells in the body.
Description
Brand Name: Palbace
Generic Name: Palbociclib
Strength: 125mg
Packing: 21 Capsules in a bottle
Form: Tablets
Palbace125Mg is generally used in combination with letrozole or fulvestrant (Faslodex) for treating certain types of advanced breast cancer in postmenopausal women. It is also given in combination with another cancer medicine, either letrozole (Femara) or fulvestrant (Faslodex).
Palbace is a renamed version of the drug Ibrance for the Indian market. It is verified by the US Food and
Drug Administration (FDA). In clinical studies, palbociclib appeared to increase survival time of patients.
Palbace comes in capsule form in 125 mg dose. 1 pack has 21 capsules.
How Palbace125Mg capsules works ?
Palbace 125mg capsule is an anti-cancer medication. It works by busy bodied with a enzyme, a sort of supermolecule within the body that helps management biological process. This stops cancer cells from dividing and growing.
It is additionally won't to treat patients with bound kinds of carc
Presently, In the US, around 12% of women develop breast cancer over the course of their lifetime. In Canada, an estimated 26,900 women were expected to be diagnosed with breast cancer in 2019 and breast cancer accounts for nearly 25% of new cases of cancer among Canadian women. Download complete report summary @
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Chronic pain is a type of pain that usually lasts for weeks to months. This pain can come and go, and it can be anywhere in the body. Chronic pain can lead to anxiety, depression, and insomnia. Chronic pain is quite different from acute pain and there are some differences between the two types. People usually experience severe pain, when it is injured by a broken bone or a cut on the skin. This pain does not last long.
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The National Pharmacy Association (NPA) survey revealed that 93 per cent of respondents experienced 'at least one month' of negative cash flow across their
pharmacy business in 2022.
Nine out of 10 pharmacy owners responding to NPA survey said they made a net loss dispensing medicines for the NHS during 2022, for at least one month of the year.
According to the poll, 48 per cent of them lost money on this core NHS service for six months or more. 45 per cent said their overall outgoings had exceeded overall
income in at least six months of the year.
NPA Chair Andrew Lane said: "This survey shows the bleak financial reality facing many independent pharmacies after years of underfunding. Dispensing at a loss and
negative cashflow is clearly unsustainable."
"This funding crisis must be addressed urgently or pharmacies will fall into a spiral of declining services and ultimately widespread closures, he added. "Tragically,
the story is playing out very much in line with independent research commissioned by the NPA last year, which warned of a nationwide financial emergency in our
sector."
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The COVID-19 pandemic has made virtual care a normal thing in the healthcare industry. More than 41 million telehealth claims were filed between April and July 2020. Here are the impacts, both positive and negative, of telemedicine.
The minimum Covid-19 self-isolation period in England will be cut to five days from seven if someone tests negative twice, health secretary Sajid Javid said on Thursday (January 13) - a move that could reduce staffing disruption in businesses and infrastructure.
The rapid spread of the Omicron variant has fuelled a spike in Covid-19 cases to record highs in Britain, and the surge has cause major disruption to the staffing of hospitals, schools and transport as staff have to self-isolate.
"We've made the decision to reduce the minimum self-isolation period to five full days in England," Javid told parliament.
"From Monday, people can test twice before they go, leaving isolation at the start of day six."
The government had previously reduced isolation period to seven days from 10 days to people in England who get a negative result on a rapid lateral flow test two days in a row.
The UK's Health Security Agency (UKHSA) said mistakes at a testing laboratory led to misreporting of tens of thousands of positive COVID-19 cases as negative
and may have resulted in the deaths of about 20 people.
Britain has one of the highest coronavirus death tolls in the world, with more than 177,000 deaths since the pandemic started in 2020.
Many experts have said the contact tracing programme fell well short of the "world-beating" system the government had promised.
An investigation by the government agency responsible for responding to public health emergencies said the Immensa laboratory in central England was found to have
misreported around 39,000 tests as negative when they should have been positive between September 2 and October 12 last year.
Community Pharmacy England (CPE) to host a Parliamentary drop-in event in July to brief MPs and Peers about the ongoing medicines supply chain issues that
are negatively affecting pharmacies and their patients across the country.
CPE's Pressures Survey earlier this year highlighted the extent of both the operational and financial impacts of medicines supply issues on pharmacy businesses,
therefore it has continued to hear from both pharmacy owners and others about the problems.
The event aims to ensure that MPs understand the problems and their impact on pharmacies.
Peter Dowd MP is hosting the event, joined by representatives from Community Pharmacy England, the Nuffield Trust, patient groups and more.
The event will also be another opportunity to talk to MPs from across the political spectrum about the very serious situation that community pharmacies still find
themselves in and the need for further investment in the sector.
Janet Morrison OBE, Chief executive of Community Pharmacy England said: "The results of our Pressures Survey earlier this year showed just how much supply issues
are continuing to negatively impact pharmacy businesses and all those who work in them. The survey found that almost all pharmacy owners (97%) are facing
significant increases in wholesaler and medicine supply issues, with 71% saying this was leading to delays in prescriptions being issued.
Pharmaceutical recalls are complicated and expensive, just like in any other business. Pharmaceutical recalls, however, pose a further risk because they might
change both short- and long-term health effects. To ensure smooth recalls with few negative effects on public health, it is crucial to understand the pharmaceutical
product recall procedure and the roles of each key player. Throughout the recall procedure, patient safety is crucially ensured by the FDA, pharmaceutical companies,
pharmacy technicians, and other healthcare professionals.
Learning about pharma recalls, procedures, and responsibilities is essential for guaranteeing patient safety for key actors like the Food and Drug Administration
(FDA), manufacturers, and other medical specialists.
RECALL CLASSIFICATIONS
Recalls can fall into one of three categories-class I, II, or III-with class I being the most serious and lethal. Products that have the potential to result in
serious, permanent complications or death are subject to Class I recalls.
Class II recalls are recommended for product flaws that have a low likelihood of harmful events or that can result in reversible side effects.
Last but not least, class III recalls typically arise from problems with packaging that do not pose a risk. Since they are frequently issued out of an abundance of
prudence rather than due to any negative impacts, many people may even describe this kind of recall as benign.
The benefits of facilitating joint health through regenerating cartilage tissue, the makers of Reparagen also speculate that the supplement could help prevent the negative side effects of other anti-inflammatory drugs.
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Disciplining kids is a major hurdle many parents face. Since little toddlers and preschool kids especially cannot handle their emotions and behaviour, it is extremely difficult to show them what's right and wrong. Though many parents use hitting or yelling as the common tools to discipline, sehat.com psychiatrists say that these methods can make the child more aggressive and stubborn.
Parents must always be vigilant towards the child and must notice all kinds of behavioural and temperament changes that occur in them. Many parents brush off such issues as something silly or make fun of them. But if such things are not dealt with properly, they can turn huge and impact your child's life in a negative way. Different kind of behaviour must be addressed immediately with the help of a child psychiatrist. Medication, counselling and regular follow up are the only ways to treat psychological issues. Here are six commonly noticed behavioural issues seen in kids.
Have you been diagnosed with diabetes? Do you think that it is going to affect your life in a negative way? Think again! Nowadays, it is possible for you to live a healthy and long life with diabetes.
It is no secret that social networking has negative psychological effects on people. It is fun and a great way to connect to different people. However, getting addicted to it is so easy that before you know it, it takes over your entire life. It can be extremely difficult to log out of social networking sites and even if you do, chances are that you log in more than a couple of times a day. It is due to this that many people across the world suffer from psychological problems.