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Global drug discovery services market will continue to grow, owing to upsurge in externalization of R&D activities, rising expenditure on R&D, and increasing incidence of chronic diseases. Expiration of patents boosting the demand for drug discovery and the introduction of innovative drug discovery technologies are projected to support the market growth during the forecast period 2019-2025. The global drug discovery services market, by type, is segmented into medicinal chemistry services, biology services, and pharmacokinetics and drug metabolism. Among these, the medicinal chemistry services segment accounted for the largest share in 2018 and is expected to grow at a high-double-digit CAGR by 2025. Increasing tendency of pharma companies to externalize discovery & development services, upsurge in the number of drug discovery & development activities, and growing R&D expenditure are the key factors driving the growth of the segment.

After a tough workout, you're bound to experience some muscle pain, since your muscles are working harder than they usually do. Here are six ways that will help relieve the soreness and ache in your muscles after a workout routine: 1. DRINK PLENTY OF WATER 2. ADD SOME HEAT 3. GET A MASSAGE 4. KEEP MOVING 5. EAT WITHIN 30 MINUTES OF EXERCISING 6. POST WORKOUT SUPPLEMENTATION If you're trying to relieve muscle pain after exercise, then you should follow these tips. The faster your body can recover from tough workouts and other physical activity, the sooner you'll be able to get back out there and stay active.

The Hyderabad Police are actively searching for UK-based pharmacist M. Ajith Kumar, who is suspected of involvement in a plot to poison his estranged wife's family in Hyderabad by contaminating their spices with arsenic. While the accused allegedly succeeded in fatally poisoning his mother-in-law through a slow method, timely arsenic testing saved the lives of others. In late June, a newlywed woman in her 30s visited a Guntur-based doctor, complaining of intense burning, tingling, and numbness in her hands and feet. The neurologist's keen observation foiled the alleged sinister plot of Ajith Kumar, suspected of using his chemical expertise to harm his wife and her family. Presently, the police are actively searching for M. Ajith Kumar, who is currently in London, in connection with the murder plot. Furthermore, the Hyderabad police have apprehended six individuals from the city who were complicit in his nefarious scheme. The investigation gathered key information from arrested suspects, including D. Vinod Kumar, a UK-based IT professional from Andhra Pradesh. Vinod Kumar's involvement in UK software projects provided by Ajith Kumar generated a substantial monthly income, leading him to assist Ajith in his plot against his estranged wife's family.

The Association of Pharmacy Technicians UK (APTUK) has urged the General Pharmaceutical Council (GPhC) to collate the data on actively enrolled on an approved course or qualification for Pharmacy Technicians of commencement of training. In a letter from Nicola Stockmann, Vice President APTUK to the GPhC to encourage the collection of data for Pre-Registration Training Pharmacy Technicians, Stockmann said: "We value the GPHC data for Pharmacy Technician registrants to track the growth and diversity of the Pharmacy Technician profession. With ongoing inclusive pharmacy practice priorities, APTUK has an organisational pledge to continue this work of all themes through actions. The demographics of the Pharmacy Technician workforce continue to have a majority of white British registrants and identifying as female; the high-level data collated which is currently available on the GPHC website does not capture those who are actively enrolled on an approved course or qualification for Pharmacy Technicians."

Living in challenging times means that the world seems to be constantly changing, and it can be hard to keep up. Along with all the other challenges you face, it's more important than ever to stay healthy. But what does that mean for you? What are the health tips that everyone should follow? There's a lot of information out there about health and wellness, and it can be overwhelming trying to figure out what's best. That's why you should check this list of the top seven health tips that everyone should follow. GET REGULAR EXERCISE Everyone needs to make time for physical activity and aim for at least 150 minutes of moderate-intensity exercise each week. This can be anything from walking or swimming to dancing or aerobics classes. Exercise not only strengthens your body, but it can also help you manage stress and improve your mood, while also boosting your immune system. If, for any reason, you're not able to get the recommended amount of exercise, try breaking up activities into smaller chunks and incorporating them into your daily routine.

If you are one of the unlucky few who require serious knee surgery, you will likely want to do everything possible to ensure a successful recovery. Knee surgeries can be difficult and frustrating, but with the right attitude and approach, you can make the process much easier on yourself. In this blog post, we will discuss six tips for recovering from serious knee surgery. Follow these tips and you will be on your way to a successful recovery! 1) FOLLOW YOUR DOCTOR'S ORDERS This may seem like an obvious tip, but it is important to follow your doctor's orders after knee surgery. Your doctor knows what is best for you and your recovery, so make sure to listen to their advice. Also, you can find useful information on the St Vincent's Private Hospitals website regarding your specific type of surgery. It is important to get well informed about your surgery so that you can be prepared for the recovery process. For example, if you are having a partial knee replacement, you will want to know what activities you should avoid during your recovery. Or, if you are having a full knee replacement, you will want to know what kind of rehabilitation exercises you should be doing. 2) GET PLENTY OF REST Your body needs time to heal after surgery, so make sure to get plenty of rest. This doesn't mean that you have to stay in bed all day, but you should avoid any strenuous activity. Take naps when you feel tired and give your body the time it needs to recover.

Assisted living facilities are for people with cognitive decline or those with trouble managing their daily activities like feeding themselves, getting dressed, or bathing. If your loved one can't perform two or more basic daily activities, they become candidates for assisted living. Choosing an assisted living facility goes beyond just signing up and moving in. The choice should be carefully considered because this is where your loved ones will probably spend the rest of their lives. So, when the time comes, you have to consider pertinent things to help you make the right decisions. Levels Of Care Provided By The Assisted Living Facility Assisted living facilities offer varying levels of care which range from lower levels of care to memory care. Having an idea about the different levels of care provided in assisted living facilities will help you ask the right questions. You should be able to know what level best suits your loved one so that their needs can be addressed adequately. For instance, a person who only needs assistance with mobility but can do other things independently will be suited for level 1 care. On the other hand, those who need additional care because they have difficulty remembering things and can't take care of themselves will be better placed in level 3 care.

Being overweight can increase your chances of having bad cholesterol in your blood. Due to high cholesterol, a person can suffer from heart related diseases. According to doctor's research, a 10-pound increase in body weight produces 10 milligrams of cholesterol in the body. Consuming unhealthy and calorie-rich foods also leads to obesity in individuals. Junk foods, such as burgers, fries, and pizza, are high in calories, which ultimately lead to this disorder. Research results show that low-liquid fructose can significantly affect glucose metabolism and lead to metabolic syndrome and fatty liver syndrome. Metabolic syndrome also includes type 2 diabetes, high blood pressure, and heart disease. One of the main reasons people develop this disorder is lack of physical activity. Most people have jobs that involve little or no physical activity for most of the day. As a result, such individuals do not use their calories and these excess calories lead to obesity. The best way to treat this disorder is to use Phentermine 37.5mg Obesity Pills Online.

The Scottish Medicines Consortium (SMC) has accepted AbbVie's RINVOQ (upadacitinib) for use within NHS Scotland for the treatment of adult patients with moderately to severely active ulcerative colitis (UC). Upadacitinib offers an additional treatment choice in the therapeutic class of janus kinase inhibitors. "Daily life with ulcerative colitis is difficult due to the debilitating and unpredictable nature of its symptoms", said Dr Jonathan Macdonald, Consultant Gastroenterologist at NHS Greater Glasgow and Clyde. "Clinical trials have shown that upadacitinib as a once daily pill controls symptoms in eight weeks for many patients and provided sustained responses at one year. The SMC's decision is good news for people with ulcerative colitis in Scotland as it provides an additional treatment option to help them gain control of their condition." The SMC decision is based on data from the induction studies U-ACHIEVE and U-ACCOMPLISH, as well as the Phase 3 U-ACHIEVE maintenance study, which demonstrated the efficacy of upadacitinib versus placebo in its ability to achieve clinical remission. The SMC's decision follows the granting of Marketing Authorisation for upadacitinib in UC in July 2022.

The General Pharmaceutical Council (GPhC) Fitness to Practise Committee has removed a pharmacy technician from Register after been found guilty of possessing 'indecent photographs of a child'. Graeme Arthur, a pharmacy technician first registered with GPhC on 1 September 2019, under the registration number 5039154, was found guilty at Peterlee Magistrate's Court in August 2022. He received an 18-month Community Order, and is subject to a Sexual Harm Prevention Order for 5 years, He was also ordered to undertake a period of rehabilitation activity for 40 days. In the remote video linking hearing held on 2 - 3 May, the Fitness to Practise Committee found Arthur's fitness to practise to be currently impaired on grounds of protection of the public and in the wider public interest of declaring and upholding the Standards of the profession and maintaining public confidence in the reputation of the profession. The committee considers this to be a serious conviction for an offence which has included possession of the most serious category of images of sexual abuse of children. It said: "Although Mr Arthur had no direct contact with the children concerned, the nature of the abuse is that it thrives on the demand from those who search for and view the images online. As such, children come to actual harm indirectly through the activity of someone viewing and possession of images of sexual abuse."

Immunogenicity refers to the capacity of a vaccine to provoke an immune response in the body. An effective immune response is characterized by the production of specific antibodies, activation of immune cells, and the development of immunological memory. The goal is to elicit a durable and robust response that can prevent or control infections. Leveraging Viral Vector Technology Viral vectors serve as essential vehicles for delivering antigenic proteins or genetic material into target cells, triggering an immune response. Biotechnology companies have been exploring advanced strategies to optimize viral vector design, aiming to enhance immunogenicity and improve vaccine effectiveness. Vector Selection: The choice of viral vector plays a crucial role in determining immunogenicity. Different viruses have unique properties and characteristics that can impact immune responses. Biotechnology companies meticulously select viral vectors that possess the desired attributes, such as the ability to infect target cells efficiently and induce strong immune responses. Genetic Engineering: Advanced genetic engineering techniques are employed to modify viral vectors, tailoring them to specific vaccine requirements. By introducing specific antigenic proteins or genetic material, researchers can stimulate the immune system to mount a targeted response. This precise manipulation enhances the vaccine's ability to elicit a robust immune reaction. Immunomodulatory Elements: Biotechnology companies are incorporating immunomodulatory elements into viral vector designs. These elements can enhance the immune response by stimulating various components of the immune system, such as antigen-presenting cells and T cells. By activating and priming these immune cells, the vaccine can generate a more potent and sustained immune response. Adjuvants: Adjuvants are substances added to vaccines to enhance their immunogenicity. They stimulate and amplify the immune response, improving the va

Dr Rod Hughes sets out how pharmacists can play a pivotal role in steering people with joint pain towards a prevention programme… Joint health supplements are big business in the UK, with millions of pounds spent over the counter every year. People turn to these supplements for various reasons, but most are seeking relief from the symptoms of arthritis, a group of painful long-term conditions thought to affect around 10 million people in this country. Osteoarthritis (OA) is the most common form of arthritis, affecting around eight million people in the UK. The condition is generally age-related, with joint pain and stiffness developing as the cartilage between the bones gradually wears away. OA changes and the inflammation involved causes difficulty moving and considerable pain. Rheumatoid arthritis (RA) tends to affect younger people and is caused by the body's immune system attacking the joints. As a nation we tend to ignore our joints until they cause us problems, resulting in an increasing number of people taking long-term analgesics to control the pain or needing surgery to repair knees and hips. Treatment guidelines followed by doctors in the UK recommend that people with arthritis are advised to maintain a healthy weight and keep physically active, while strengthening their muscles and protecting any damaged joints during daily activities.

A diabetes medicine, Mounjaro, has been approved by the Medicines and Healthcare Products Regulatory Agency (MHRA) to treat overweight patients. The weight loss medication originally developed for Type 2 diabetes is now accessible to individuals aged 18 and over who are dealing with obesity and weight-related health issues. The active ingredient, tirzepatide, works by making the patient feel fuller and reducing food cravings. The injection helps individuals lose 20 per cent of their body weight, and are advised to follow a reduced-calorie diet and increase physical activity simultaneously. Although it is not authorised to use on the NHS as yet but future approvals can be predicted.

NHS England has launched a prescription savings campaign, particularly for those living with long-term conditions. The campaign is specifically for individuals residing in deprived areas as they receive more prescriptions than people in affluent areas. It is also known that people with low income could be entitled to help with costs or free prescriptions depending on their circumstances. The Pharmacists' Defence Association (PDA), an active member of the Prescription Charges Coalition, is actively striving to eliminate prescription charges in England as well. They are focussing on "NHS England's current efforts to minimise charges so that members practising in England can alert patients to this possibility".

The Medicines and Healthcare products Regulatory Agency (MHRA) has authorised a new drug today (1 November) to treat severe alopecia areata. Litfulo is the new hard capsule medicine with a recommended dosage of just 50 mg per day. It contains an active ingredient, ritlecitinib, an enzyme inhibitor treatment for patients over 12 years. Ritlecitinib works by reducing the activity of enzymes in the body called JAK3 and TEC kinases that cause hair follicle inflammation. This reduction in inflammation leads to hair regrowth in patients with alopecia areata. Alopecia areata is an autoimmune disease, where the body's own immune system attacks hair follicles leading to hair loss on the scalp and other parts of the body.

Pharmacists globally are broadening their roles to support self-care, aiming to enhance patient health outcomes through increased contributions and proactive behaviours, according to a new report. However, significant barriers, including inadequate funding and limited access to patient records, impede the optimisation of self-care activities and outcomes improvement in this area, the International Pharmaceutical Federation (FIP) said in its report. The FIP report, titled 'Community Pharmacy Insights: Supporting the Need for Self-Care,' gathers insights from 238 respondents across 55 countries with the aim of providing evidence-based policy support for workforce development. Nearly all respondents (93.2 per cent) indicated that pharmacists should actively engage in providing self-care support, FIP said. Furthermore, 48.9 per cent supported the involvement of pharmacy technicians, while 39.2 per cent endorsed the participation of pharmacy assistants and other team members in offering self-care support.

WHAT IS PROTEINASE K MADE OF? Proteinase K is known enzyme belonging to the class of serine proteases that cleave adjacent to the carboxylic group peptide bonds of aromatic and aliphatic amino acids. It's also exhibited a very broad cleavage specificity. The enzyme was discovered in extracts of the fungus Engyodontium album. HOW DOES PROTEINASE K WORK? In molecular biology, main application of proteinase K is to digest proteins during nucleic acids purification in order to remove protein contaminants: - Proteinase K quickly inactivates nucleases (enzymes that digest nucleic acids) that degrade DNA or RNA molecules during the cleansing. - Proteinase K is activated by calcium. It does not affect the activity of the proteinase, but protects again autolysis, improves thermal stability, and regulates substrate binding capacity. To increase the stability of Proteinase K, thereby enhancing its action, Urea as well as SDS (sodium dodecyl sulfate) or elevated temperature at 37-60C is commonly used. Inactivation of Proteinase K is occurring at temperature above 65C. WHAT IS THE PURPOSE OF PROTEINASES? Proteinase K is used to break down proteins in cell lysates (tissues, cell culture cells) and to release nucleic acids due to its action described above. Proteinase K application purpose: DNA isolation from various tissues; Removal of DNAses and RNAses: Proteinase K and RNases can act together in the lysis buffer to degrades contaminating RNAs and proteins;

Ginger is an age-old herb that has had extensive usage in history for its numerous natural therapeutic effects, especially as an "anti-emetic." The best-known proof indicates that ginger is an effective and affordable remedy for nauseatic and vomiting ailments and is safe. The pleasing zesty "kick" from the root of Zingiber officinale, the ginger plant, is what produces ginger ale, ginger tea, sweets, loaves of bread, and many Asian dishes so delicious. Ginger adds an aromatic tang to both sweet and spicy foods. As ginger is frequently suggested for its stomach-settling impacts, you may wonder whether it's a proven way to treat nauseatic ailments naturally. This article reevaluates the efficacy and safety of ginger for nausea and the most promising practices for using it. How does Ginger Help with Nausea? According to PubMed Central, the highly appreciated database from the National Institutes of Health, it's believed that ginger fetches its therapeutic qualities from gingerol, the main bioactive ingredient in fresh ginger, and complementary blends called shogaols, which provide the root its savory flavor. Shogaols are more robust in dried ginger, with 6-shogaol as the primary source of antioxidants. At the same time, gingerols are more plentiful in raw ginger. Some examination has revealed that ginger and its compounds may improve digestive function and speed up stomach emptying feel, relieving nausea. Its anti-inflammatory traits may improve digestive activity and sustain the discharge of blood-pressure-regulating hormones to relax your body and ease nausea. Other Health Benefits of Ginger Being an anti-inflammatory, antioxidant, and digestive aid, it has been used as a natural treatment for helping to alleviate nausea and other symptoms. It can be used to treat: Heartburn Indigestion Motion sickness Reduce joint pain Soothe sore throats Minimize the duration of colds and flu viruses Ease menstrual cramps Prevent cancer cell growth Improve choleste

Medical professionals often prescribe semaglutide to patients who have type 2 diabetes. Along with a balanced diet and regular exercise, it has also shown to be an incredibly efficient weight loss aid for patients. As the active ingredient in well-known brand-name drugs such as Wegovy, Ozempic, and Rybelsus, semaglutide is currently on everybody's lips. But what exactly is semaglutide? Does it really work for weight loss? We'll find an answer for you in this article, and explain the main benefits of using semaglutide for weight loss. What Is Semaglutide? A number of diabetic and weight loss medications, including Wegovy, Ozempic, and Rybelsus, have semaglutide as their active ingredient. This substance is a synthetic form of the hormone glucagon-like peptide-1 (GLP-1), that occurs naturally. Developed by the company Novo Nordisk, semaglutide was first approved by the FDA in 2017 as an injection for the treatment of adult type 2 diabetes (as part of the approval procedure for Ozempic). In 2019, the Food and Drug Administration approved a novel semaglutide form known as Rybelsus. Rybelsus was the first oral GLP-1 receptor agonist for the treatment of type 2 diabetes in the United States.