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GlaxoSmithKline (GSK) says initial tests of the antibody-based Covid-19 therapy it is developing with US partner Vir suggest the drug is effective against the Omicron variant. A GSK statement on Thursday (December 2) said that lab tests and a study on hamsters have demonstrated the sotrovimab antibody cocktail to work against viruses that were bio-engineered to carry a number of hallmark mutations of the new variant. The tests are continuing to confirm the results against all of the Omicron mutations, with an update expected by the end of the year, it added. The antibody is designed to latch on to the spike protein on the surface of the coronavirus, but Omicron has been found to have an unusually high amount of mutations on that protein. "Sotrovimab was deliberately designed with a mutating virus in mind," said Vir chief executive George Scangos, adding that the drug was targeting a region of the spike protein that was highly unlikely to mutate.

British drugmaker GSK said on Tuesday (December 7) its antibody-based Covid-19 therapy with US partner Vir Biotechnology is effective against all mutations of the new Omicron coronavirus variant, citing new data from early-stage studies. The data, yet to be published in a peer-reviewed medical journal, shows that the companies' treatment, sotrovimab, is effective against all 37 identified mutations to date in the spike protein, GSK said in a statement. Last week, another pre-clinical data showed that the drug had worked against key mutations of the Omicron variant. Sotrovimab is designed to latch on to the spike protein on the surface of the coronavirus, but Omicron has been found to have an unusually high number of mutations on that protein. "These pre-clinical data demonstrate the potential for our monoclonal antibody to be effective against the latest variant, Omicron, plus all other variants of concern defined to date by the WHO," GSK chief scientific officer Hal Barron said.

Delivering Difficult News is organized by eMedEvents Corporation. Consequences of delivering news poorly and Employ the SPIKES model into clinical practice

The NHS Confederation has urged the government to reconsider its 'living with Covid' plan and introduce mitigating actions that will help avoid further critical incidents being declared at the NHS front-line. The organisation said the high rates of Covid is having a major impact on the delivery of health services and slowing down efforts to reduce large waiting lists, noting that the country has been in the grip of another spike in Covid cases resulting from the Omicron BA.2 variant. With more than 20,000 patients now in hospital with Covid (or who have Covid but are in hospital for other reasons) and high staff absences, NHS is facing huge operational challenges, harming efforts to reduce waiting times in other areas, it said.

Indian drugmaker Dr Reddy's Laboratories will launch its generic version of Merck's antiviral Covid-19 pill, molnupiravir, and price it at 35 rupees ($0.4693) per capsule, a company spokesperson said on Tuesday (January 4). The overall cost for a patient treated with a 5-day course of 40 capsules of the generic drug, to be sold under brand name 'Molflu', will come up to 1,400 rupees ($18.77). In comparison, the treatment with Merck's pill in the United States costs $700. "Molflu is expected to be available from early next week in pharmacies throughout (India) with particular focus on states with high caseload of Covid-19," the company spokesperson said. India last week gave emergency use approval to along with two vaccines, as the country braces for a possible spike in coronavirus cases due to the rapidly spreading Omicron variant.

The minimum Covid-19 self-isolation period in England will be cut to five days from seven if someone tests negative twice, health secretary Sajid Javid said on Thursday (January 13) - a move that could reduce staffing disruption in businesses and infrastructure. The rapid spread of the Omicron variant has fuelled a spike in Covid-19 cases to record highs in Britain, and the surge has cause major disruption to the staffing of hospitals, schools and transport as staff have to self-isolate. "We've made the decision to reduce the minimum self-isolation period to five full days in England," Javid told parliament. "From Monday, people can test twice before they go, leaving isolation at the start of day six." The government had previously reduced isolation period to seven days from 10 days to people in England who get a negative result on a rapid lateral flow test two days in a row.

Walgreens Boots Alliance on Tuesday (June 28) scrapped the plan to sell its UK high street pharmacy chain saying no third party was able to make an adequate offer due to the turmoil in global financial markets. Walgreens' move to call off the sale comes as private equity bidders Apollo Global and TDR faced headwinds in raising financing for the deal, as banks were wary of underwriting large chunks of the financing due to tough market conditions. Boots was initially valued at as much as £8bn with the auction process being led by Goldman Sachs. Global economic uncertainty and rising inflation have triggered a spike in interest rates as central banks have rushed to take action in the most widespread tightening of monetary policy for more than two decades, making deal financing costlier and harder to access. Walgreens had put its Boots UK business up for sale after announcing a strategic review in January as the second-largest US pharmacy chain renewed its focus on domestic healthcare. The company said the decision to retain Boots and No7 Beauty Company was also underpinned by their ongoing strong performance.

Superdrug has reported more than 400 per cent spike in sale of the chickenpox vaccines in the UK. To protect children against the disease during chickenpox season, nearly nine out of 10 patients (87 per cent) have taken their wards under the age of five for vaccination in the last eight weeks. Chickenpox can be a seasonal disease with children usually catching it in the winter and spring, with UK peaks often between March and May. The last two years of spending time in and out of various lockdowns have meant less interaction between people, and so less transmission across the general population. Caris Newson, head of healthcare services at Superdrug, said: "One of the knock-on effects of Covid is that people have a greater awareness and understanding of the benefits that vaccines can offer. "We launched the chickenpox vaccination service five years ago in 2017 and it's now that we're beginning to see greater interest in how it can support family health. In fact, our fully qualified nurses have told us that they've had more parents ask about the chickenpox vaccination service, and word of mouth has then spread amongst parents and schools."

he Healthcare Distribution Association (HDA) and the Pharmaceutical Services Negotiation Committee (PSNC) have urged the NHS England and the Department of Health and Social Care (DHSC) to issue urgent communications requesting that all those involved in medicines supply do not hoard, stockpile or over-prescribe Strep A antibiotics. In a statement HDA said that the sudden spike in demand for antibiotics used for the treatment of Strep A has meant that there is not enough of these medicines in the supply chain currently to meet this increased demand. As a result, wholesalers are working extremely hard with manufacturers to increase the supply of antibiotics. It added: "As regards pricing, the prices charged to pharmacies by HDA wholesale distributors will directly reflect the increase in prices wholesalers are having to pay for these medicines from manufacturers at the moment, in order to be able to continue supplying these medicines to pharmacies. This will be the case until supply and demand are more in sync."

From over-the-counter flu tablets to crucial antibiotics and antidepressants, medicines are running scarce in UK pharmacies this year, causing concerns among patients, the government, and the wider pharma industry. Drug shortages have accelerated over the past year due to a clutch of problems including the after-effects of the pandemic on supply chains, the war in Ukraine, and soaring input costs weighing on manufacturers. More recently, a sudden spike in respiratory infections - another by-product of Covid-19 that neither pharma companies nor the government were able to predict - has deepened the crisis, with 70 commonly taken drugs out of stock in Britain as of February. The problem is not unique to the UK. In a recent survey of groups representing pharmacies in 29 European countries, three quarters said shortages were worse this winter than a year ago, with a quarter reporting more than 600 drugs in short supply. The US is also facing significant shortages of popular prescription drugs like amoxicillin and Adderall, an ADHD medication. To some extent, the current disruption is laying bare wider challenges facing the industry for several years that were only exacerbated by the pandemic. The over-reliance on foreign suppliers for most active pharmaceutical ingredients (APIs) is one of them. This model has left companies more susceptible to supply shocks, which have in turn increased in frequency and severity due to pandemic lockdowns, the war in Ukraine and other issues such as the shortage of shipping containers. Pharma's long and opaque supply chains, alongside regulatory complexities, also mean it is taking longer for drugmakers to reconfigure manufacturing and distribution in times of additional need.

Within 24 hours of the Princess of Wales, Kate Middleton's, cancer diagnosis, National Health Service (NHS) England saw a 373% spike in visits to its cancer page, highlighting the growing focus on cancer awareness. Similarly, charities like Macmillan Cancer Support charity experienced increased traffic, with nearly 100,000 visits to their support pages since the announcement. Traffic to the NHS website's cancer symptoms page surged significantly, recording a remarkable 4,172 visits within three hours of the release of the Princess's video message. This sudden increase translated to an average of one visit every three seconds, a substantial rise from the 1,922 visits recorded during the same timeframe a week earlier. Notably, visits to the symptoms page peaked immediately after the announcement, with 1,678 visits recorded between 6 pm and 7 pm on the day of the announcement.

Insect bites and stings typically increase in the summer in England. This year, however, there's been an earlier-than-usual spike in the number of people seeking NHS advice on the condition. According to the NHS England, visits to its insect bites and stings web page have nearly tripled in the last three weeks compared to the same period last year, peaking at an average of one visit every 22 seconds in the past week. Over the span of 21 days, a total of 68,986 visited the page, marking a significant 162 per cent increase compared to the 26,368 visits recorded in the first three weeks of May 2023. Although insect bites or stings are usually not serious and people tend to get better after a few days, the health service has cautioned that they can lead to infection or severe allergic reactions. People are encouraged to refer to the NHS website for advice or visit their local pharmacy to get advice and treatment for common health conditions, including infected insect bites.

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Excessive sugar consumption has become one of the leading medical and dental health issues. Sugar is one of the main causes of tooth decay and has a number of medical drawbacks associated with it. Eating too much sugar can contribute to people having too many calories, which can lead to weight gain. Being overweight increases your risk of health problems such as heart disease, some cancers, and type 2 diabetes. As people have become more aware of the issues surrounding refined sugar, a number of sugar alternatives have come onto the market. In this article, we'll be looking at the most popular Alternatives to Refined Sugar, how they work, and if they are actually a healthier option. Natural Sweeteners One of the more popular alternatives to refined sugar is so-called natural sweeteners. A good example of a natural sweetener is coconut sugar. Coconut sugar is also called coconut palm sugar. It's a natural sugar made from coconut palm sap, which is the sugary circulating fluid of the coconut plant. It is often confused with palm sugar, which is similar but made from a different type of palm tree. Coconut sugar is still metabolized by oral bacteria in a similar way to refined sugar but it has a much lower glycaemic index. This means it does not trigger the same blood sugar spikes and crashes associated with refined sugar. It also contains small amounts of various minerals, giving it a slight nutritional edge on refined sugar. However, despite being marginally more healthy, replacing all your refined sugar with natural sweeteners will not drastically improve your diet or your oral health. Honey and Syrups Various natural liquid sweeteners are alternatives to refined sugar during cooking. Examples include honey, maple syrup, date syrup, brown rice syrup, and agave syrup. These syrups do have some slight nutritional value, however, they also have varying levels of unrefined sugar, making some only marginally more healthy than sugar. Nutritionists

The drop in vaccination rates is believed to be driving a surge in measles cases in England, mainly in the West Midlands. As of 18 January, 216 confirmed cases and 103 probable cases have been reported in the region since 1 October 2023, the UK Health Security Agency (UKHSA) revealed. The majority of cases (around 80 per cent) were from Birmingham, with children aged under 10 years being infected the most. UKHSA Chief Executive, Professor Dame Jenny Harries has warned that the outbreak could spread further to other towns and cities if urgent action is not taken to increase Measles, Mumps and Rubella (MMR) vaccination uptake in areas at greatest risk.