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the "Global Lung Cancer Drugs Market" will grow at a CAGR of 13.6% during the forecast period. The market has witnessed steady growth in the past few years with the introduction of novel products, which have augmented the acceptance of immunotherapy drugs in the market. The market is fueled by upsurge in the incidence of lung cancer cases across the globe - owing to increasing diagnosis rate and mainly due to increasing tobacco consumption, increase in the lung cancer treatment rates, increasing rate of effective drug approvals as first-line therapies, strategic deals to develop new products, increasing R&D spending, and rapid industrialization leading to increased pollution. The report provides complete details about the sub-segments of the lung cancer drugs market. Through this report, the key stakeholders can know about the major trends, drivers, investments, vertical player's initiatives, and government initiatives towards the disease management in the upcoming years along with details of the existing pureplay companies and new players entering the market.

The General Pharmaceutical Council (GPhC) has proposed a 7.5 per cent increase in all fees for pharmacies, pharmacists, pharmacy technicians, and foundation trainees, including those for registration and renewal from April 2024. According to the GPhC's proposal the pharmacist renewal fee would increase by £19 from £257 to £276; the pharmacy technician renewal fee would increase by £9 from £121 to £130 and the pharmacy premises renewal fee would increase by £27 from £365 to £392 Any changes would be effective from April 2024, which means fees will remain at current levels for this financial year, giving registrants and applicants time to prepare for any increase in subsequent years. Fees have been frozen for the last two years (2022 and 2023) to help reduce pressure on both pharmacy professionals and pharmacy owners. Chief Executive, Duncan Rudkin, said: "In the last few years, we have been able to avoid raising many of these fees by improving our efficiency and by using our financial reserves to cover any gap between our income and our outgoings. While we are continuing to look for ways to make savings, we now have to consider increasing fees.

The General Pharmaceutical Council (GPhC) has decided to increase the renewal fees of pharmacists, pharmacy technicians, and pharmacy premises by 7.5% from April 2024. The pharmacy technician's renewal fee will see an increase by £9 from £121 to £130, pharmacists fees from £257 to £276, and pharmacy premises from £365 to £392. The following decision came even despite the renewal fees being frozen for individual registrants since 2019 and for pharmacy premises since 2021. This move was facilitated through cost savings measures like using financial reserves and downsizing to a smaller office. However, the council confirmed that the fee hike is due to higher rates of inflation, increase in utility bills and supplier costs. Duncan Rudkin, Chief Executive and Registrar of the GPhC, said: "We know that these are challenging times and that this increase will come as unwelcome news to those we regulate. But to be effective in our role of protecting the public we need to make sure the fees we charge cover the cost of regulation going forward."

Dispensing activity by community pharmacy in England has witnessed a 4.2 per cent increase across the year 2021 till March 2022, the Pharmacy Market Review 2022 report revealed. The report launched by Christie & Co, said: "All pharmacy settings saw improvements in dispensing numbers, with standard community settings seeing the highest increase of 4.2 per cent, with the average moving to 7,173 items, albeit still below the combined average." "The independent sector fared better than corporate pharmacy, with a combined average increase of 3.5 per cent versus a 1.8 per cent increase in corporate dispensing. Despite some improvement, integrated pharmacies remained the lowest at 1.9 per cent, in part due to the continued restrictions on patient access." Dispensing activity for England across the year to March 2022 increased by 4.5 per cent to an average of 7,765 items per month, reversing the decline witnessed in 2021.

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Researchers have projected the rates of liver disease and associated deaths due to increased alcohol consumption during the Covid-19 pandemic. The research has been published in the 'Hepatology Journal'. A team led by investigators at Massachusetts General Hospital used data from a national survey of US adults on their drinking habits that found that excessive drinking (such as binge drinking) increased by 21 per cent during the Covid-19 pandemic. The scientists simulated the drinking trajectories and liver disease trends in all US adults. They estimated that a one-year increase in alcohol consumption during the Covid-19 pandemic will result in 8,000 additional deaths from alcohol-related liver disease, 18,700 cases of liver failure, and 1,000 cases of liver cancer by 2040. In the short term, alcohol consumption changes due to Covid-19 are expected to cause 100 additional deaths and 2,800 additional cases of liver failure by 2023. The researchers noted that a sustained increase in alcohol consumption for more than one year could result in 19-35 per cent additional mortality.

Boots pharmacists will receive a pay rise of 4.5 per cent as the pharmacy multiple and PDA Union jointly announce this year's pay settlement. Following discussions between Boots management services and the PDA Union negotiators, the agreement was reached in relation to this year's pay claim, effective from 1 November 2022. The union also announced that those who have already had a pay increase on or since 1 August 2022, where that increase has been less than 4.5 per cent, a 'top up' increase will be provided, from 1 November 2022, to ensure that all eligible members of the bargaining unit receive a pay increment of not less than 4.5 per cent in 2022. Boots and the PDA Union have agreed an increase to the pay of those above the maximum market range by 4 per cent with an additional 0.5 per cent non-consolidated payment.

The proposed increase in the national living wage (NLW) is expected to impose an implementation cost of £150 million to £195 million on the community pharmacy sector, Community Pharmacy England (CPE) has warned. Chancellor Jeremy Hunt recently announced a 9.8 per cent increase in the national living wage, raising it from £10.42 to £11.44. "The Autumn Statement overlooks the knock-on effects these measures will have on small businesses like community pharmacies," CPE Chief Executive Janet Morrison said in a statement. "The majority of pharmacies employ staff on or around the NLW, which has increased nearly 40 per cent since the start of the current contractual framework." "This is at a time when pharmacies have faced a 30 per cent real terms reduction in funding since 2015," Morrison added. "No viable business can absorb these cost increases without significant support. This is just another cost pressure that pharmacies cannot control and must be addressed through a sustainable, long-term funding arrangement."

The NHS Business Services Authority (NHSBSA) has published its latest quarterly report on medicines used in mental health in England, specifically those used to treat anxiety, depression, psychosis, attention deficit hyperactivity disorder (ADHD), and dementia. Data from April to June 2024 show that 800,000 central nervous system (CNS) stimulants and ADHD drugs were prescribed to 230,000 identified patients. Both prescribing and dispensing of ADHD drugs continue to rise, with a 4.8 per cent increase in prescribed items and a 4.7 per cent rise in identified patients compared to the previous quarter. CNS stimulants and ADHD medications saw the largest increase in costs among the five drug categories, rising by 6.4 per cent to £36 million. The report reveals a modest increase in the prescribing of antidepressants, with 23 million antidepressant items prescribed to an estimated 6.9 million identified patients between April and June 2024. This represents a small increase of 1.5 per cent for prescribed items and a less than one per cent rise in identified patients compared to the previous quarter.

High-Intensity Interval Training (HIIT) is an effective workout method known for its ability to boost metabolism and burn calories quickly. By combining short bursts of intense exercise with brief rest or lower-intensity periods, HIIT elevates heart rate, promotes fat loss, and increases endurance. It's a popular choice for those with busy schedules who want maximum results in minimal time. Here's a closer look at how HIIT boosts metabolism, why it's effective, and how to incorporate it into a fitness routine. --- ### **How HIIT Boosts Metabolism** 1. **EPOC (Excess Post-Exercise Oxygen Consumption)** HIIT is particularly effective in triggering EPOC, often referred to as the "afterburn effect." After intense exercise, your body requires extra oxygen to restore itself to a resting state. This process burns more calories for up to 24 hours after the workout, even while you're at rest. Traditional steady-state cardio doesn't achieve this level of afterburn, making HIIT a superior choice for those wanting to increase caloric burn over a longer period. 2. **Improved Fat Oxidation** Studies show that HIIT can enhance fat oxidation, which means your body becomes more efficient at burning fat for energy. This is particularly beneficial for weight management, as HIIT not only burns calories during the workout but also encourages fat-burning during recovery. 3. **Hormone Production** HIIT stimulates the production of growth hormone and adrenaline, which are both associated with increased fat metabolism. These hormones also promote muscle repair and recovery, making HIIT effective for both fat loss and muscle preservation. 4. **Increased Mitochondrial Density** Regular HIIT workouts can increase the number and efficiency of mitochondria, the "powerhouses" of cells. This boost in mitochondrial density enhances your body's ability to produce energy, which can increase metabolic rate over time. --- ### **Benefits of HIIT** - **Time E

Preterm deliveries contribute to 50% of the neonatal morbidities in the world. In this era of working mothers, high risk pregnancies, increased stress levels, preterm deliveries are quite common. Around 10% of the child births all over the world are preterm deliveries. What are the factors contributing to a preterm delivery? Multiple pregnancies like twins or triplets as a result of increasing infertility treatment. Increased maternal age, more than 35 years or late conception among elderly women. Stress and increased work pressure among pregnant working women. What is preterm labor? When the onset of labor starts before 37 weeks of gestation in a pregnancy beyond 20 weeks, it is termed as a preterm labor. You can experience on and off pain in your abdomen, radiating to the back and thighs which usually does not subside with rest.

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The National Pharmacy Association (NPA) has welcomed the Chancellor's commitment to increase the NHS budget, hoping that 'community pharmacies benefit from this investment'. The association is urging the government to address years of underfunding so that community pharmacies can avoid staff lay-offs to cover the increasing costs of the national living wage. The government's uplift of the National Living Wage was confirmed in its latest budget announcement to tackle the cost of living crisis. The NHS budget will also be increased in each of the next two years by £3.3bn. A recent NPA commissioned report by Professor David Taylor from University College London predicted that wage inflation and other cost pressures could combine with funding cuts to lead to cut-backs and pharmacy closures.

The Pharmacists' Defence Association (PDA) Union says it will be reaching out to LloydsPharmacy soon over a better deal on salary increase after the majority of its members rejected a three per cent offer made by the company recently. Paul Day, director, PDA Union told Pharmacy Business: "The PDA Union will communicate the response of employed pharmacists to the company and seek further discussion to try and find an offer that will be acceptable to union members. "Both management and union representatives have a vested interest in working to find such a solution and that is the outcome we hope to achieve." After months of negotiation by the PDA Union, the company offered a three per cent increase in salaries from the 1.8 per cent in the earlier offer made by the company. "Through negotiation over last few months that was increased to 3.0 per cent, plus a long term incentive plan (LTIP). Though the LTIP potentially offers large bonuses, it isn't guaranteed. Therefore what we put to members was the confirmed offer of three per cent increase in salaries," said Paul.

The UK Health Security Agency (UKHSA) has published the latest national surveillance data on antibiotic prescribing and resistance. The English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) report showed an increase in antibiotic use in all settings (apart from dental) in 2022. According to the report, antibiotic prescribing rose by 8.4 per cent in 2022 compared with 2021, although the number remains below 2019 pre-pandemic levels. "There are many reasons behind the increase in prescribing, one of which is likely related to decreased immunity and exposure to infections during the COVID-19 pandemic that may have underpinned the increased transmission in co-circulating infections, namely: influenza (flu), respiratory syncytial virus (RSV) and group A streptococcus (GAS)," the report stated.

The National Pharmacy Association (NPA), the Company Chemists' Association (CCA), Community Pharmacy England (CPE), and the Independent Pharmacies Association (IPA) have united in urging the government to shield community pharmacies from the impact of the Budget increases. In a joint letter to the health secretary Wes Streeting MP, they have highlighted that rises in employers' National Insurance contributions and the National Living Wage could cost community pharmacies £200 million a year in unplanned costs. They have warned the government that 'without mitigation, these additional costs will push many pharmacies more towards insolvency', leading to more closures and cuts to vital health services for patients. From April 2025, the national living wage will increase by 6.7 per cent to £12.21 per hour, and the national minimum wage for 18-20-year-olds will increase by 16.3 per cent to £10 per hour.

Pharmacy contractors continue to grapple with profit pressures despite many reporting significant sales revenue increases, according to Hutchings Consultants' England Pharmacy Market Update 2024. The report emphasises that gross profit margins are under considerable strain due to factors such as rising wholesale drug costs, the dispensing of certain drug lines at a loss, reduced drug tariff reimbursements, and ongoing medicine shortages. These challenges have led to a growing number of pharmacies reporting substantial declines in their profit margins this year. For instance, Cohens Chemists reported a £5.7 million loss in the last financial year, even as sales reached £253 million. Similarly, Day Lewis, the UK's second-largest independent pharmacy chain, experienced a 5.9% sales increase driven by growth in prescription dispensing, over-the-counter sales, and pharmacy services, yet faced a 32% drop in pre-tax profits due to heightened administration costs, which included inflation-driven increases in staff, energy, utilities, and rent. The average profit margin has declined to 33% in 2024, down from 34.4% the previous year.