WORKUP AND DIAGNOSIS OF A SOLITARY THYROID NODULE from Townsend: Sabiston Textbook of S... - 3 views
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Rapid growth and signs of possible invasion, such as pain or hoarseness, are most suggestive, but not conclusive of malignancy
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Clinical groups with the highest risk for malignancy in a thyroid nodule are children, males, adults younger than 30 or older than 60 years, and those exposed to radiation therapy, especially during childhood
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history of specific endocrine disorders
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Technetium pertechnetate (99mTc) is taken up rapidly by the normal activity of follicular cells. It is trapped by follicular cells, but not organified. 99mTc has a short half-life and low radiation dose. Its rapid absorption allows quick evaluation of increased uptake (so-called hot) or hypofunctioning (so-called cold) areas of the thyroid.
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131I has a longer half-life (8 days) and emits higher levels of β-radiation. 131I is optimal for imaging thyroid carcinoma.