These data indicate that fish oil feeding downregulated the endogenous PPAR-activation system and increased antioxidant gene expressions to protect against ROS excess
Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production.
Takahashi M, Tsuboyama-Kasaoka N, Nakatani T, Ishii M, Tsutsumi S, Aburatani H, Ezaki O.
Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G338-48.
PMID: 11804856