Loren DJ, Seeram NP, Schulman RN, Holtzman DM. \nMaternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury.\nPediatr Res. 2005 Jun;57(6):858-64. Epub 2005 Mar 17.\nPMID: 1577483
Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer.
Druesne-Pecollo N, Tehard B, Mallet Y, Gerber M, Norat T, Hercberg S, Latino-Martel P.
Lancet Oncol. 2009 Feb;10(2):173-80. Review.
PMID: 19185835
doi:10.1016/S1470-2045(09)70019-
Pomegranate juice: a heart-healthy fruit juice.
Basu A, Penugonda K.
Nutr Rev. 2009 Jan;67(1):49-56.
PMID: 19146506
DOI: 10.1111/j.1753-4887.2008.00133.x
The beverage maté: a risk factor for cancer of the head and neck.
Goldenberg D, Golz A, Joachims HZ.
Head Neck. 2003 Jul;25(7):595-601. Review.
PMID: 12808663
DOI: 10.1002/hed.10288
Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.
Kidd P.
Altern Med Rev. 2003 Aug;8(3):223-46. Review.
PMID: 12946237
Th1 pathways typically produce activation of cytotoxic T
lymphocytes (Tc), NK cells, macrophages, and monocytes, all of
which can attack cancer cells and generally defend against tumors.
55 IFN-gamma and other Th1 cytokines are typically lower in
advanced cancer patients, while the Th2 marker IL-4 can be higher
or unchanged.56 Nodules of non-small cell lung cancer freshly
removed from patients expressed a marked imbalance toward Th2, as
did biopsy samples from basal cell carcinoma.57 In prostate cancer
patients IL-2 was low (Th1) and IL-10 high.58 IL-10 is a confirmed
Th1-suppressive cytokine, and heightened IL-10 is a common factor
in cancer.55
IL-10 has a variety of suppressive effects that include inhibiting
Th1 cytokine production, down-regulating APC and NK cell function,
and lowering overall T-cell proliferation.57 Especially under the
influence of IL-4 (Th2), tumor cells apparently up-regulate IL-10
that suppresses nearby killer cells. Tumor-derived IL-10 has been
documented in lymphoma, ovarian carcinoma, melanoma, neuroblastoma,
and renal cell and colon carcinoma.57 IL-12 is another cytokine
that can be up-regulated by Th1 activity and inhibited by Th2.59 A
low IL-12/IL-10 ratio was found in cervical cancer patients.55
Recent clinical studies suggest elevated IL-10 is predictive of a
poor prognosis. 57 With both IL-4 and IL-10 being proven inhibitors
of Th1 and promoters of Th2 activity, the recognized capability of
cancerous tissue to suppress immunity is readily rationalized.
Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study.
Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, Saag KG; Iowa Women's Health Study.
Arthritis Rheum. 2004 Jan;50(1):72-7.
PMID: 14730601
DOI: 10.1002/art.11434
CONCLUSION: Greater intake of vitamin D may be associated with a lower risk of RA in older women, although this finding is hypothesis generating.
Ecological studies of ultraviolet B, vitamin D and cancer since 2000.
Grant WB, Mohr SB.
Ann Epidemiol. 2009 Jul;19(7):446-54. Epub 2009 Mar 9.
PMID: 19269856
CONCLUSION: These findings provide strong evidence that vitamin D status plays an important role in controlling the outcome of cancer. Support for the UVB-vitamin D-cancer theory is now scientifically strong enough to warrant use of vitamin D in cancer prevention, and as a component of treatment. More research studies would help to explore whether there are benefits beyond the substantial effects that have been observed.