White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation.
Grube BJ, Eng ET, Kao YC, Kwon A, Chen S.
J Nutr. 2001 Dec;131(12):3288-93.
PMID: 11739882
Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus).
Chen S, Oh SR, Phung S, Hur G, Ye JJ, Kwok SL, Shrode GE, Belury M, Adams LS, Williams D.
Cancer Res. 2006 Dec 15;66(24):12026-34.
PMID: 17178902
doi: 10.1158/0008-5472.CAN-06-2206
A heat-stable extract of white button mushrooms (Agaricus bisporus) with potential chemopreventive and immunomodulating activities. Phytochemicals, such as polysaccharides and especially beta-D-glucans found in the white button mushroom extract, bind to and inhibit the activity of aromatase, an enzyme responsible for the conversion of androgens to estrogens and which is often upregulated in breast cancer cells. The consequent decrease in estrogen production may result in the suppression of estrogen-dependent cellular proliferation. In addition, this extract may promote dendritic cell (DC) maturation, increase interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production, and may enhance natural killer (NK) cell activity, thus amplifying both innate and T cell-mediated immune responses against cancer cells. Check for active clinical trials or closed clinical trials using this agent.