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Esperion Therapeutics' non-statin therapy "bempedoic acid" has shown modest results in reducing the risk of major cardiovascular events in statin-intolerant patients in the cholesterol lowering via bempedoic acid, an ACL-inhibiting regimen (CLEAR Outcomes) trial, revealed GlobalData, a leading data and analytics company. As a result, there is substantial room for improvement in this space as a potential approval is expected in Australia in near-term based on these results, said GlobalData. According to GlobalData's Pharmaceutical Intelligence Center, the total number of diagnosed prevalent cases of dyslipidemia in Australia is expected to increase at a compound annual growth rate of approximately 1.2% from 5.2 million in 2022 to 5.4 million in 2025. Neha Myneni, Pharma Analyst at GlobalData, comments: "Bempedoic acid joins several statin alternatives that have shown the potential to reduce cardiac illnesses. However, with not much significant improvement in the outcomes, there exists a clear room for improvement for non-statin therapies in this space." Bempedoic acid is the sixth class of cholesterol-lowering drugs (other than cholesteryl-ester transfer protein isoform (CETPi) inhibitors), that has demonstrated the potential to reduce heart attacks and strokes. Other class of therapies with similar potential currently marketed in Australia include statins, bile acid resins, niacin, ezetimibe, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors (alirocumab, evolocumab, and inclisiran).

Suffering a brain injury is no easy thing. The plurality of potential symptoms meets with the potential long-term effects to create a poor prognosis for many unfortunate enough to experience them. But new technological leaps could pave the way to a better quality of life. What is a Brain Injury? The above question might seem a simple one, with a simple answer. But brain injuries are by no means simple, and by no means simply defined. There are two major categories under which a brain injury can fall: hypoxic and traumatic. Of civil brain injury claims in the UK, traumatic brain injuries (TBIs) are the most common - with 95% of claims revolving around some form of traumatic injury or incident. TBIs are brain injuries suffered as a result of a specific or direct injury. The brain is damaged through direct contact or the transfer of force. A direct strike to the head is in an assault or a serious fall might compromise the cranium, sending shockwaves of energy through the brain and potentially crushing the skull into the cranial cavity. Alternatively, a car accident or sudden stop might see the brain bashed against the occipital bone, causing internal trauma and intracranial hypertension. Hypoxic brain injuries refer specifically to injuries caused as a result of loss of blood or oxygen to the head. These injuries reflect birth injuries that might lead to cerebral palsy, or serious medical events that might alter the brain's response to stimuli. How are Brain Injuries Diagnosed and Treated? While the potential causes of a brain injury are plain to see, diagnosing a brain injury is not as straightforward. There are immediate symptoms that can indicate brain injury, such as the 'fencing response' which can indicate a severe rotational brain injury. Conscious patients might also exhibit difficulty speaking, remembering key pieces of information or responding to any stimuli.

Computer Science Tuesday, April 25, 2023 Computer hardware Computer hardware is the physical components that make up a computer system. It includes everything from the central processing unit (CPU) to the monitor, keyboard, and mouse. Understanding the different types of hardware and how they work together is essential for anyone who works with computers. In this article, we will explore the various components of computer hardware, including internal and external components, and the peripherals that connect to them. We will also discuss the importance of hardware maintenance, the latest advancements in computer technology, and factors to consider when choosing the right hardware for your needs. Whether you are a computer technician, a gamer, or simply someone who uses a computer for everyday tasks, this article will help you better understand the world of computer hardware. Introduction to Computer Hardware Computer hardware refers to the physical components that make up a computer system. It includes everything from the processor and memory to input/output devices such as the keyboard and monitor. In this article, we will explore the different types of computer hardware and their functions. What is Computer Hardware Computer hardware refers to the physical components of a computer system. It includes all the components that can be touched, seen, and used to interact with a computer, such as the monitor, keyboard, and mouse. Hardware is different from computer software, which refers to the programs and applications that run on a computer system. History of Computer Hardware The history of computer hardware dates back to the 1820s when Charles Babbage, an English mathematician, and inventor, designed the first analytical engine, which was considered to be the first mechanical computer. With time, more complex electronic computers were developed, including the first Intel microprocessor in 1971. Since then, computer hardware has continued to evolve, becoming

The Competition and Market Authority (CMA) has suggested regulatory levers to curb "potential competition risk" from hub and spoke dispensing. In its response to the hub and spoke dispensing consultation, led by the Department for Health and Social Care (DHSC) last week, the competition watchdog said that a pro-active approach to monitoring the effect of hub and spoke dispensing and subsequent early consideration of any competition concerns was likely to be more effective and potentially less costly than any "ex-post enforcement any ex-post enforcement or unpicking of subsequently embedded competition issues". The competition watchdog has made a few suggestions to identify and remove the barriers to competition that might emerge with the new business models entering the market. It has asked the department to enable a "more level playing field". "Smaller independent pharmacies should, have improved access to automation and new dispensing models," it said.

A Curious Mind: Foster Your Creative Potential For Better Life [Megan Coulter] on Amazon.com. *FREE* shipping on qualifying offers. A Curious Mind - Quiet The Power Of Introverts The book “A Curious Minds – Foster Your Creative Potential For Better Life” introduces you to persistent

Community pharmacies in England will have to go through a clinical audit focusing on valproate, following an agreement reached between the PSNC and NHS England and NHS Improvement (NHSE&I). The audit, a part of NHS contractual requirements, aims to reduce the potential harm caused by taking valproate during pregnancy. The 2021/22 audit will be based on the Pharmacy Quality Scheme (PQS) audit, allowing contractors to close the cycle by re-auditing their practice. NHSE&I recently shared the results of the PQS 2019/20 valproate audit. Around 5.6 per cent of the 12,068 girls or women of childbearing potential who participated in the audit said they were not advised in line with the MHRA Drug Safety Update 2018 relating to the potential impact on an unborn child.

Working in an office environment can be hazardous to your health. From sitting on a chair all day to exposure to harmful chemicals, many potential health hazards can occur in the workplace. While some health hazards are out of your control, there are many things you can do to help prevent them. Here are seven efficient ways to prevent health hazards at the workplace: 1. TAKE HEALTH AND SAFETY TRAINING Health and safety training is an efficient way to prevent health hazards at the workplace for several reasons. First, it helps employees to be aware of potential hazards in their work environment. This knowledge can then be used to take steps to avoid or control these hazards. Second, health and safety training provides employees with the skills and knowledge necessary to identify and report potential health hazards, especially those working in medical laboratories with frequent exposure to blood, chemicals, and other pathogens. This can help to ensure that any problems are quickly addressed and corrected. Finally, health and safety training helps to create a culture of safety in the workplace. This safety culture can encourage employees to take personal responsibility for their own health and safety, as well as the health and safety of their coworkers.

The Department of Health and Social Care (DHSC) launched a new Innovative Medicines Fund on Tuesday (June 7) under which £340 million has been made available to purchase potentially life-saving drugs early. This will allow NHS patients in England to have early access to potentially life-saving and cutting-edge treatments Health secretary Sajid Javid said: "I want NHS patients to be the first in the world to access the most promising and revolutionary treatments that could extend or save their lives. "The launch of the Innovative Medicines Fund delivers another manifesto pledge and will fast-track cutting-edge medicines to adults and children to give people renewed hope for a better future." A total of £680 million has been ringfenced for the Innovative Medicines Fund and Cancer Drugs Fund - £340 million each - to fast-track medicines to NHS patients. DHSC said: "The Innovative Medicines Fund will provide quick access to novel treatments, including potentially lifesaving gene therapies for serious conditions with few treatment options. It often takes longer for pharmaceutical companies to collect data on a medicine's clinical and cost effectiveness for rare diseases due to the smaller patient cohort.

Water fasting, abstaining from all food and drinks except water for a set period, has gained popularity as a potential weight-loss method. It carries potential risks and is not suitable for everyone. Focusing on long-term, sustainable lifestyle changes through a balanced diet, regular physical activity, and mindful eating habits is the best path to achieving and maintaining a healthy weight.While it can lead to Water Fasting Benefits for weight loss, it's crucial to approach this practice with cautious awareness of its potential benefits, drawbacks, and safety considerations. Here's a balanced exploration: Potential Benefits for Weight Loss: Calorie Restriction: The core principle behind any weight loss is burning more calories than you consume. Water fasting drastically restricting calorie intake, leading to weight loss, but not necessarily fat loss. Ketosis: After prolonged fasting (usually over 48 hours), your body shifts from burning glucose to burning fat for fuel (ketosis). This can accelerate fat loss, but requires close monitoring due to potential side effects. Improved Insulin Sensitivity: Some studies suggest short-term water fasting can improve insulin sensitivity, potentially aiding weight management in the long run.

On the occasion of World Sepsis Day, PAGB, the consumer healthcare association, has underscored the significant role that over-the-counter (OTC) antiseptics can play in preventing sepsis, potentially saving the NHS millions of pounds each year. Sepsis is a life-threatening condition where the body's immune system overreacts to an infection, causing damage to tissues and organs. Early recognition and treatment are crucial, as sepsis can rapidly escalate without prompt care. Symptoms of sepsis include confusion or slurred speech, fever, severe breathlessness, blotchy or mottled skin, and a lack of urination. PAGB emphasised that using OTC medicines early on can help prevent infections from worsening and potentially leading to serious conditions like sepsis. Michelle Riddalls, CEO of PAGB, stated: "Early prevention is always the best treatment for conditions that could potentially lead to sepsis. "If you don't get the right care for sepsis quickly it can be life-threatening so it's essential to seek immediate help if you or someone else has any symptoms.

Regular health screenings are an essential part of maintaining wellness, and one vital test for women is the Pap smear. Known for its role in early detection of cervical cancer, the Pap smear is a simple yet powerful tool that can potentially save lives. In this blog, we will explore the significance of Pap smears, what the procedure involves, and how often you should get tested. The Importance of Regular Local Screenings Staying on top of your health requires vigilance, and regular local screenings play an indispensable role in this effort. Local screenings, like Pap smears, are essential in detecting potential health issues at their earliest stages, making treatments more effective and improving outcomes. By participating in these routine checks, you not only safeguard your health but also contribute to broader public health efforts by identifying and addressing potential outbreaks or health trends within the community. Whether that's HPV and Pap tests in Singapore or a mammogram in the US, local screenings are crucial for maintaining overall wellness. This is especially true for Pap smears, as they play a significant role in detecting and preventing cervical cancer.

Clubbell Yoga: Action Potential by Summer Huntington contains six full-length follow along classes, each class which is 75-90 minutes long begins with Awakening drills and flows that prime the specific movement patterns.The Second phase of the class is conditioning, which comprises of 4 Clubbell Yoga conditioning exercises in 90/30 seconds work/rest ratio. Then comes the practice section that reinforces the previous sections with a weighted and unweighted yoga flow, complimentary to the zone of mechanical advantage presented. Grounding flow: This conditioning exercises and flows focus on balance, endurance, and grounding. You will have to take it slow and breathe in deeply...click link for more

Pharmacy bodies and MPs discussed on support needed to unlock the "full potential" of community pharmacy at the All Pharmacy Party Group (APPG)'s general meeting held in Westminster on Tuesday (01 November). The attendees of the meeting were Janet Morrison OBE, Chief Executive of Pharmaceutical Services Negotiating Committee; Malcolm Harrison, Chief Executive of The Company Chemists' Association; Thorrun Govind, Chair of the Royal Pharmaceutical Society; Sanjeev Panesar, National Pharmacy Association Board Member, and Pharmacist Superintendent and Owner of the Pan Pharmacy Group; and Sandeep Dhami, Association of Independent Multiple Pharmacies member and superintendent at MW Phillips Chemist At the session, 18 parliamentarians were briefed on the myriad of ways pharmacies contribute to the health of the nation. The panel of experts also highlighted that pharmacists are 'running out of fuel' with the growing challenges such as flat funding, workforce shortages and the cost-of-living crisis impacting pharmacies' ability to deliver vital services.

The Pharmacist' Defence Association (PDA) has welcomed the General Pharmaceutical Council (GPhC) and the Pharmaceutical Society of Northern Ireland (PSNI)'s plan to ensure a more robust, fair and positive experience for trainees, provisionally registered and potential pharmacists who will be sitting the November 2022 assessment. "Many candidates at the latest (June 2022) assessment experienced significant delays, technical issues, inadequate invigilation, and disturbances in test centres around the UK as the newly appointed company BTL ran the high-stakes pharmacist examinations for the first time. The next online exam is due in November 2022 and the PDA welcome proposed improvements to be introduced before that sitting," said the association. For some, provisional registration was the accepted response from the GPhC, but for others, such as potential pharmacists who did not want the provisional role, those unable to find a suitable provisional post, or some that did not meet the criteria for provisional registration, they found themselves in financial difficulties through no fault of their own, having reasonably expected to have joined the register in the Summer.

Royal Pharmaceutical Society in England and the Royal College of General Practitioners have published recommendations for the roll-out and success of the GP Community Pharmacist Consultation Service (GP CPCS). These recommendations follow a workshop with stakeholders from pharmacy, general practice and representative bodies, examining ways to maximise the potential of the service and meet growing demand on the health service. The workshop report made five recommendations: The NHS England and Improvement should provide additional investment in local system support and resources to drive the CPCS implementation and uptake between general practice and community pharmacy. National representative bodies should work with NHS E&I to develop national and local engagement and streamline communication plans for CPCS referral pathway. Focus on expanding the role of community pharmacists in the management of minor illness. Evaluation of CPCS service and its impacts on general practice workload, patient outcomes and health inequalities.

Ergonomic Wheelchair is a lightweight aluminum wheelchair designed for the ultimate mobility experience at a competitive price. Ergonomic Ergonomic Wheelchair is a lightweight aluminum wheelchair designed for the ultimate mobility experience at a competitive price. Ergonomic Wheelchair is easy to pick up, fold up, and transport in any vehicle. It is a folding backrest and seat with optional quick release wheels and make folding breakdown quick and simple. Ergonomic Wheelchair uses a lightweight Aircraft-grade Aluminum frame making it the lightest folding chair. Ergonomic Wheelchair is a light-weight Manual Wheelchair. It is ergonomically designed manual wheelchair built for comfort, health and durability. It uses S-Ergo seat design that helps in distributing weight and reduces the potential for bed sores. Ergonomic wheelchair provides users with a large selection of ultra lightweight wheelchairs that can help improve your life. Ergonomic wheelchair features that include a high strength lightweight frame, foldable and easy to store, breathable anti-bacterial, anti-staining, removable and machine washable cushion. It is also includes the exclusive S-Shape Seating System, which provides increased stability, better weight distribution and lowers the risk of pressure sores and spinal injury. Ergonomic Wheelchair provides efficient pressure relief by spreading weight over a greater area at the same time provides stabilization and reduced sliding. Removable upholstery is equipped with AEGIS Microbe Shield anti-biotic technology, odor and stain resistan, ergonomic and lightweight with compact, wider arm pad that provide comfort support. Ergonomic wheelchair has a folding backrest. Ergonomic "S" Seating: Ergonomic Wheelchair has ergonomic seating system which is very popular in USA and has setup a benchmark for handicap person using Ergolite KM-2501. Ergonomic seat has a slight 'S" shape to it, just like the natural body's shape. Ergonomic "S" shape provide

Oxford Cannabinoid Technologies Holdings plc, which specialises in developing cannabis-derived medicines with pain-relieving properties, has successfully administered the first-in-human dose of its lead pharmaceutical drug compound, OCT461201, in its phase 1 clinical trial. The company holds a portfolio of four drug candidates intended for use as licensed pain medications. The drug is a selective cannabinoid receptor type 2 agonist with the potential to treat chemotherapy-induced peripheral neuropathy and irritable bowel syndrome. The UK trial, conducted by Simbec Research Limited, part of Simbec-Orion Group Ltd., is progressing with healthy volunteers, OCTP said in a statement. Using a single ascending dose protocol, the primary objective is to demonstrate OCT461201's safety and tolerability, while providing information on its pharmacokinetic profile, to confirm its value as a potential drug. Results from the trial, funded entirely by OCTP's existing resources, are expected in the third quarter of 2023, the statement added.

Day Lewis Pharmacy has enlisted Locate a Locum, a Belfast-based healthcare technology innovator, to deploy and manage a digital solution aimed at enhancing locum staffing and management across its 267-pharmacy network. "We sought a faster, user-friendly system for instant locum bookings, particularly for last-minute shifts," said Sam Patel, Executive Director at Day Lewis Pharmacy. "This tool improves communication between potential locums and our coordinators, creating more opportunities to attract talent from across the country. Our customers are our priority, and ensuring they have access to staff and advice when needed is our main focus." Locate a Locum will implement a cloud-based digital solution across the Day Lewis Pharmacy estate, allowing locums to securely search, manage, request, and receive payment for shifts, Day Lewis said in a statement. This platform enables locum staff to manage their work diaries, location preferences, and commitments, promoting balanced work-life planning. "The Locate a Locum platform allows for swift, complete payments to our locums and offers them instant booking, eliminating the need for shift confirmation wait times," Patel added. "In a dynamic market with rising demand for pharmacy services, this platform is a game-changer, driving growth and unlocking potential."

Errors of any kind in medical settings can have dire consequences for patients and healthcare systems. Unfortunately, negligence, misdiagnosis, and medication errors aren't uncommon in the UK. In this article, we discuss the nature of medication errors in the NHS, outline potential causes, and delve into how and why technology could be turning the tide on the issue. Prevalence and consequences of medication errors Medication errors are incidents involved with the administering, prescribing, dispensing or monitoring of medicine to patients. It can happen at many different steps in the healthcare process and by any medical professional in the system. Many cases are avoidable. According to analysis from BMJ, there are an estimated 237 million medication errors made in England every year. The majority of these are minor errors, but 1 in 4 cases has the potential to cause moderate to serious harm to patients. Not only do these errors cost the NHS significantly, at almost £100 million every year, but there is a shocking cost to public health. Lives are being lost because of medication errors which is unforgivable and tragic for the families involved. Drains on NHS resources have widespread impacts on public health and the operations of healthcare organisations up and down the country. Individual errors and mistakes may seem inconsequential (in minor cases), but they all add up in the big picture to a significant concern for policymakers.

Approximately 25 million GP appointments and 5 million A&E visits are utilised each year for self-treatable illnesses. If these individuals chose to self-treat using over-the-counter (OTC) medications, the potential savings for NHS could amount to at least £1.7 billion annually, according to a research commissioned by Proprietary Association of Great Britain. The study, conducted by analysts at Frontier Economics, revealed that embracing self-care could bring an additional economic benefit of £350 million annually, as employees would avoid unnecessary time off from work for medical appointments. Apart from the savings resulting from the increased OTC medicine use, the report emphasises the potential benefits of reclassifying more prescription-only medications (POMs). A mere 5 per cent reduction in NHS prescribing levels and spending could lead to an annual cost-saving of £1.4 billion, encompassing both prescription costs and GP appointments, it said. "This substantial amount could greatly alleviate financial pressures on the NHS and offer essential resources for recruiting and training much-needed healthcare professionals."