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The Forum's perspective on present and future technological and societal changes is captured in their 'Principled Framework for the Fourth Industrial Revolution.' Philbeck explained the four principles that characterize the Fourth Industrial Revolution. * Think systems, not technologies. Individual technologies are interesting, but it is their systemic impact that matters. Emerging technologies challenge our societal values and norms, sometimes for good, but sometimes also in negative ways; the Fourth Industrial Revolution will have civilization-changing impact-on species, on the planet, on geopolitics, and on the global economy. Philbeck suggested that wealth creation and aggregation supported by this phase of technological innovation may challenge societal commitments to accessibility, inclusivity, and fairness and create the need for relentless worker re-education. As Philbeck stated, "The costs for greater productivity are often externalized to stakeholders who are not involved in a particular technology's development." * Empowering, not determining. The Forum urges an approach to the Fourth Industrial Revolution that honors existing social principles. "We need to take a stance toward technology and technological systems that empowers society and acts counter to fatalistic and deterministic views, so that society and its agency is not nullified," said Philbeck. "Technologies are not forces; we have the ability to shape them and decide on how they are applied." * Future by design, and not by default. Seeking a future by design requires active governance. There are many types of governance-by individuals, by governments, by civic society, and by companies. Philbeck argued that failure to pay attention to critical governance questions in consideration of the Fourth Industrial Revolution means societies are likely to allow undemocratic, random, and potentially malicious forces to shape the future of technological systems and th

"Yeah, I know, trickle down. But instead of wealth miraculously trickling down, it's debt that miraculously trickles up. How many Americans have mortgages or rents to pay every month that gobble up 40-50% or more from their incomes? That'd be a useful stat. Model that, Janet!"

Because thinking minds are different from evolving organisms and self-assembling molecules, we cannot expect them to use the same means-mechanisms like genetic drift and thermal vibrations-to overcome deep valleys in the landscapes they explore. But they must have some way to achieve the same purpose. As it turns out, they have more than just one-many more. But one of the most important is play.

The model, called Deep Claim, predicts both when and how much an insurance company will pay for a given claim in advance of any payment they make. It was trained with three million de-identified claims including parameters like demographic information, diagnoses, treatments, and billed amounts. Using this information, Deep Claim can not only predict the date and amount of payments with reasonable certainty, but also the likeliest reasonings for any claim denial in play.

Under the program, expected to be rolled out this week, companies will also face unwelcome curbs on stock buybacks, dividend payments and executive pay. And the sheer length of time it has taken to start the program - two months - has already forced many firms to seek alternatives. That has left industries divided, with manufacturers eager to tap the loans but retailers wanting more, as many businesses face the prospect of extensive layoffs or even bankruptcy.

Given constant emergence of new infectious threats, Infectious Diseases (ID) should be one of the most attractive medical specialties to students and trainees. Yet, ID Fellowship programs continue to not fill in the match, and ID remains among the lowest paid specialties. Nearly 35 years after Dr. Petersdorf first asked the question, we find ourselves once again wondering, "Whither Infectious Diseases?" To answer this question, and align with predominant US market forces, ID experts should push for: 1) restrictions regarding utilization of ID diagnostics and antimicrobial agents; 2) pay-for-performance measures regarding antimicrobial prescribing rates; and 3) healthcare reform as called for by the American College of Physicians to move away from fee-for-service medicine. Einstein said, "Continuing to do the same thing over and over and expecting a different result is the definition of insanity." We must move towards alignment with market forces, to benefit our patients, society, and our colleagues.

Antigen tests don't amplify their protein signal, so they are inherently less sensitive. To make matters worse, that signal gets diluted when samples are mixed with the liquid needed to enable the material to flow across test strips. As a result, most antigen tests have a sensitivity of anywhere between 50% and 90%-in other words, one in two infected people might incorrectly be told they don't have the virus. Last month, Spanish health authorities returned thousands of SARS-CoV-2 antigen tests to the Chinese firm Shengzhen Bioeasy Biotechnology after finding the tests correctly identified infected people only 30% of the time, according to a report by the Spanish newspaper El Pais.

Funding for health campaigns is surprisingly low when you consider they're often so valuable that they pay for themselves.

Prepublication peer review should be abolished. We consider the effects that such a change will have on the social structure of science, paying particular attention to the changed incentive structure and the likely effects on the behaviour of individual scientists. We evaluate these changes from the perspective of epistemic consequentialism. We find that where the effects of abolishing prepublication peer review can be evaluated with a reasonable level of confidence based on presently available evidence, they are either positive or neutral. We conclude that on present evidence abolishing peer review weakly dominates the status quo.