At a certain point in the 17th century, the known world suddenly became, in one particular and peculiar sense, unknowable. This seems, on the face of it, counter-intuitive: This was, after all, a time when modern science came into existence, when mathematics and methodology reorganized the capacity and reach of thought, when thinkers such as Descartes, Galileo and Newton altered the conceptual fabric of the universe, and gave the woozy gauze of what had been imagined the hard contours of what could be measured. But at the same time, this period of immense, almost incredible, transformation meant the end of homo universalis; if man could now measure everything, he was no longer the measure of everything.