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Information on Study sponsored by the National Institute of Neurological Disorders and Stroke. Study completed and examined how the brain controls movements in patients with certain types of cerebral palsy. Last updated March 2008

Study being conducted to better understand how the brain controls movement, to learn more about movement disorders and to train movement disorder specialists.

Study to improve understanding of the pathophysiology of movement disorders by performing small behavioral, electrophysiological and neuroimaging substudies. This will allow identifying dysfunction of the central nervous system that causes behavioral abnormalities seen in movement disorder patients.

Study will collect information on the different ways people control limb and body movements. This information will be used to develop a database on normal movements and adaptive movements of people who have diseases that affect the way they move. The database will serve as a tool to improve diagnosis and treatment of patients with movement-related problems.

Information regarding ongoing study being sponsored by Hawaii Pacific Health to assess the predictive value of Generalized Movements for Early Prediction of Cerebral Palsy

Stanford trial assessing use of Theta-burst transcranial magnetic stimulation (TBS) as a new, non-invasive therapeutic intervention to aid in physical therapy and symptom amelioration of dystonia and spasticity

Baclofen Efficacy and Safety Trials - Pediatric Pharmacokinetic and Pharmacodynamic Study of Oral Baclofen for the Treatment of Spasticity Associated with Cerebral Palsy (BEST-PK/PD)

NINDS sponsored study will evaluate patients with muscle stiffness for possible participation in current or future research studies. It will determine the cause of muscle stiffness or cramps and measure the severity of symptoms

Study completed and sponsored by Hvidovre University Hospital to investigate if physical therapy with strength training is better at improving muscle and gait function after anti-spastic treatment with Botulinum toxin compared to physical therapy without strength training in children with cerebral palsy.

Completed study is to provide further information regarding the risks and benefits of Dysport in marketed indications.

Stanford University completed study on the relationship between spasticity and strength in children with cerebral palsy and reducing spasticity permits and increase in strength

Study to investigate if patients who have had a stroke and suffer from spasticity might benefit from being given BOTOX® in addition to the normal Standard Care. Spasticity is characterized by stiffness or frequent cramps accompanied by pain and abnormal movements and can prevent the carrying out of everyday tasks such as walking and getting dressed. BOTOX® is a neurotoxin, which is used to prevent the contraction of muscle fibre and has been shown to reduce spasticity significantly. Patients will be enrolled in this study at about 33 locations in Europe and Canada

Study will provide information about changes that occur in the motor neurons of the spinal cord (the nerve cells that control the muscles) when the motor cortex (the region of the brain that controls movement) is unable to send messages to the spinal cord and muscles in the normal way. This information will help elucidate how the nervous system adapts after injury or disease of the motor cortex.

Study to develop a comprehensive spasticity management program which will then be developed for the individual. Clinical and outcome assessments at baseline and at follow-up will include measures of range of motion, global spasticity according to a modified Ashworth scale, and the time and number of staff required for the task. In addition, video will be obtained of caregivers performing each participant's care area tasks at baseline and follow-up to allow an independent external reviewer to judge task difficulty