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U.S. Department of Health &Human Services - Agency for Healthcare Research and Quality. The mission of CERTs is to conduct research and provide education that will advance the optimal use of drugs, medical devices, and biological products; increase awareness of the benefits and risks of therapeutics; and improve quality while cutting the costs of care. CERTs consists of 14 research centers and a Coordinating Center. The Centers receive funds from both public and private sources, with core financial support from the Agency for Healthcare Research and Quality (AHRQ).

Constraint-Induced Movement Therapy (CIT) is a recent therapeutic intervention for people with hemiplegia involving restraint of the non-involved extremity and structured practice with the more affected extremity. CIT involves restraint of the less affected extremity of children with hemiplegic cerebral palsy, along with practice with the more affected extremity.

Government sponsored effort designed to provide early incentives that encourage and facilitate the discovery of new therapeutic agency.

Theta-burst transcranial magnetic stimulation (TBS) is a type of repetitive transcranial magnetic stimulation (rTMS) method that reduces the excitability of a small region of brain for less than one hour. Since dystonia and spasticity may be associated with increased excitability of motor cortex, we expect that by reducing the excitability of motor cortex with TBS we will temporarily improve these symptoms and hopefully open avenues in the future for the use of TBS as a new, non-invasive therapeutic intervention to aid in physical therapy and symptom amelioration of dystonia and spasticity.

Study being conducted to identify specific motor signatures of different forms of dystonia. Study will examine abnormal co-activation in distal and proximal muscles to evaluate the characteristics of the loss of selectivity of the motor command in mobile vs. fixed dystonia. We will also study possible cognitive and limbic components of the disease, examining the influence of cognitive and emotional loads on movement production.

NCBI PubMed Abstract, Department of Pediatrics, University of Tennessee Study involving piglets to determine whether the generation of superoxide anion occurs primarily during asphyxia or whether reventilation must take place, 2) to investigate the effects of indomethacin pretreatment at a therapeutic dose of 0.2 mg/kg i.v. on superoxide anion generation, and 3) to investigate the effects of oxypurinol, an oxygen free radical scavenger, on superoxide anion production during asphyxia/reventilation