The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature.
Köstner K, Denzer N, Müller CS, Klein R, Tilgen W, Reichrath J.
Anticancer Res. 2009 Sep;29(9):3511-36. Review.
PMID: 19667145
CONCLUSION: Significant associations with VDR polymorphisms have been reported in cancer of the breast (Fok1, Bsm1, Taq1, Apa1, poly (A)), prostate (Fok1, Bsm1, Taq1, poly (A)), skin (Fok1, Bsm1, A-1210), colorectum (Fok1, Bsm1), ovary (Fok1, Apa1) and bladder (Fok1), and in renal cell carcinoma (Taq1, Apa1). However, conflicting data have been reported for most malignancies. After careful evaluation of the actual literature, it can be summarized that data indicating an association of VDR polymorphisms and cancer risk are strongest for breast cancer (Bsm1, Fok1), prostate cancer (Fok1) and malignant melanoma (MM) (Fok1). Data indicating an association of VDR polymorphisms and cancer prognosis are strongest for prostate cancer (Fok1), breast cancer (Bsm1, Taq1), MM (Bsm1) and renal cell carcinoma (Taq1).
Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk.
Raimondi S, Johansson H, Maisonneuve P, Gandini S.
Carcinogenesis. 2009 Jul;30(7):1170-80. Epub 2009 Apr 29. Review.
PMID: 19403841
Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer.
Druesne-Pecollo N, Tehard B, Mallet Y, Gerber M, Norat T, Hercberg S, Latino-Martel P.
Lancet Oncol. 2009 Feb;10(2):173-80. Review.
PMID: 19185835
doi:10.1016/S1470-2045(09)70019-
Li H, Stampfer MJ, Hollis JBW, Mucci LA, Gaziano JM, et al. (2007)
A Prospective Study of Plasma Vitamin D Metabolites, Vitamin D Receptor Polymorphisms, and Prostate Cancer.
PLoS Med 4(3): e103
doi:10.1371/journal.pmed.0040103