The Senate vote marks the beginning of the end for the long march of healthcare reform through the US legislative system. The Senate bill must now be merged with the House version of healthcare reform, approved in November. Substantial differences between the two approaches remain, particularly in regard to antiabortion language, methods of financing, and a governmnt-run public option insurance plan.A conference committee of members from both chambers will struggle over this harmonization. In its own way, that task could be almost as difficult as the Senate debate, as lawmakers struggle to keep intact the language passed on their side of Capitol Hill. The Senate bill, like its House counterpart, would prevent the insurance industry from denying benefits to people with pre-existing health conditions. It provides subsidies to help low- and middle-income residents purchase that insurance. And it establishes state marketplaces, called "exchanges," whereby individuals without employer-provided insurance, and some small businessess, could buy coverage.