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16s 18s ITS Sequencing CapitalBio The full length of bacteria 16S rDNA is about 1540bp, including 10 conserved regions and 9 hypervariable regions, in which the difference of conserved region in bacteria is not significant while the hypervariable region has high specificity. Therefore, some hypervariable regions (usually V3 and V4 regions) can be sequenced to analyze the bacterial community diversity.

16S 18S ITS rRNA Gene Sequencing, 16S 18S ITS Amplicon Metagenomic Sequencing | Capitalbio

he development of next-generation sequencing (NGS) over the past 15 to 20 years has seen multiple technologies rapidly leapfrogging each other's milestones to sequence more DNA faster, cheaper, and more accurately. While Illumina sequencers still predominate, other NGS providers are gaining ground, providing important alternative options for sequencing mechanisms, read lengths, run times, ease-of-use, and scalability. This article aims to guide researchers through the main differences among today's common NGS platforms, with a special focus on the offerings from Capitalbio Technology.

A variety of products and services have been exported to more than 30 countries and regions in North America, Europe, Asia, and so on. The biochip-related products developed have twice won the National Technology Invention Award's second prize.

CNV Sequencing, Semiconductor Sequencing IVD Medical Device | Capitalbio

Epilepsy-related Gene Detection The Epilepsy-related gene testing of CapitalBio Technology is based on BES4000 semi-conductor sequencing platform, using target region capture and NGS technology together to detect the genes related epilepsy.

Human Mitochondrial Genome Detection Mitochondrial diseases refer to a group of multi-system diseases caused by dysfunction of mitochondrial respiratory chain leading to ATP synthesis disorder, can affect muscles, central nervous system, kidneys, cardiovascular, eye, ear, digestive, endocrine, cardiovascular and renal systems individually or simultaneously. It can occur in any part of the body or at any age, the incidence is about 1/8500. For this test, CapitalBio use two long-segment PCR amplification and high-throughput sequencing technologies to analyze the full length of the entire mitochondrial gene (16569bp), the latest Cambridge version of the mitochondrial genome NC_012920 was used as a reference for comparison and analysis.

Hereditary Deafness Gene Detection (227 Genes+Mitochondrial Genome) This test is based on NGS technology, it can detect 227 nuclear genomes + mitochondrial genome sequence, covering reported non-syndromic deafness and syndrome deafness.

Trisomy 21 (Down syndrome), trisomy 18 (Edward's syndrome), and trisomy 13 (Patau's syndrome) are the three most prevalent autosomal aneuploid diseases. The incidence in newborns is 1/(600-800), 1/(3500-8000), and 1/(7000-20000). Intellectual disability, developmental delay, multiple deformities, reproductive disorders, etc. are common in children. Using a fetal chromosome aneuploidy (T21, T18, T13) detection kit (semiconductor sequencing), doctors can reliably identify these conditions in unborn children (trisomy 21, trisomy 18, and trisomy 13).

Fetal Aneuploidies (Trisomy 21, Trisomy 18 and Trisomy 13) Detection IVD Medical Device | Capitalbio