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If internal and international migrants comprised a nation, it would be the third most populous country in the world, just after China and India. Thus, there can be little doubt that population mobility is among the leading policy issues of the 21st century. However, policies to protect migrants and global health have so far been hampered by inadequate policy attention and poor international coordination. This is the conclusion of a new article in PLoS Medicine arguing that current policy-making on migration and health has been conducted within sector silos, which frequently have different goals. Yet, population mobility is wholly compatible with health-promoting strategies for migrants if decision-makers coordinate across borders and policy sectors, say the authors, who are also serving as guest editors of a new series in PLoS Medicine on migration & health that launches this week.