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Anna McLean

Would you like lemon, or BPA with your water? - 0 views

likeafishinwater.com/...e-lemon-or-bpa-with-your-water

shared by Anna McLean on 11 Jun 10 - Cached
  • The only problem was that vinyl products generally contain significant amounts of Bisphenol-A (BPA), a plastic additive, exposure to which causes disruption of endocrine hormones
  • BPA in plastic baby bottles
  • What makes BPA such a problem? It affects everyone, but developing fetuses and small children are particularly vulnerable.
  • ...2 more annotations...
  • It alters the levels of endocrine hormones, which has effects ranging from learning disabilities to diseases and altered sexual development.
  • BPA is currently banned in Chicago, the State of Minnesota and Suffolk County, NY.
Liz Richardson

Our Stolen Future - 0 views

www.ourstolenfuture.org/index.htm

EED general BPA

shared by Liz Richardson on 14 Jun 10 - Cached
  • Liz Richardson on 14 Jun 10
     
    What the effects of EEDs mean for our bodies, our species, our planet. Most recent additions concerning BPA in plastics.
Vanessa Ward

Endocrine Disruptors and the Obesity Epidemic -- Heindel 76 (2): 247 -- Toxicological S... - 1 views

toxsci.oxfordjournals.org/...247

obesity endocrine disruption

shared by Vanessa Ward on 25 May 10 - Cached
  • "We are faced with the seeming paradox of increased adiposity at both ends of the birth weight spectrum—higher BMI with higher birth weight and increased central obesity with lower birth weight" (Oken and Gillman, 2003). Thus prevention of childhood and adult obesity must start in utero.
  • Indeed, many synthetic chemicals are actually used to increase weight in animals.
  • This article provides fascinating examples of chemicals that have been tested for toxicity by standard tests that resulted in weight gain in the animals at lower doses than those that caused any obvious toxicity.
  • ...7 more annotations...
  • Chemicals having endocrine-disrupting activity rise to the top of the list as most act via receptors linked to activation of transcriptional activity.
  • In the adult, loss of circulating estrogen due to ovariectomy leads to increased body and adipose tissue weights. Estrogen receptor alpha knockout mice have a significantly increased body fat content, and estrogen decreases the activity of lipoprotein lipase
  • estrogenic endocrine-disrupting chemical bisphenol A at concentrations as low as 2 µg/ml, in the presence of insulin, stimulated differentiation of the 3T3L1 cells into adipocytes
  • he fact that an environmental chemical has the potential to stimulate growth of "preadipocytes" has enormous implications for the area of obesity and its control.
  • Differentiation could be inhibited and more potential fat cells could be formed, as seems to be the case with NP, or differentiation could be stimulated, as appears to be the case with BPA
  • Will these results extrapolate to the in vivo situation in rodents and other animal models?
  • Only time and more research will tell, but the door has been opened by the novel work being highlighted.
  • Vanessa Ward on 25 May 10
     
    An article discussing how the area of research of obesity as a result of endocrine disrupting chemical exposure could be a beneficial area for intervention and prevention studies of obesity. This was one of the first articles I found directly addressing how endocrine disrupting chemical exposure can lead to a predisposition to obesity
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