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Tero Toivanen

How to unleash your brain's inner genius - life - 03 June 2009 - New Scientist - 0 views

  • A flurry of research published earlier this year in the journal Philosophical Transactions of the Royal Society B paints a very different picture. It turns out that these skills are far more common than previously thought. They may even arise from traits found in the general population, implying that savants are not fundamentally different from the rest of us. What's more, these skills may only blossom after years of obsessive practice, raising the question of whether many more people might cultivate similar skills, if only they had the motivation.
  • One of the biggest clues to the origins of savant talent lies in the fact that savants are far more common within the autistic population than among people with other mental difficulties.
  • Previously, about 1 in 10 people with autism were thought to have a special ability but in April, Patricia Howlin at the Institute of Psychiatry at King's College London found a much higher figure in the autistic adults she surveyed for savant skills or an exceptional cognitive ability.
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  • Savant skills included more fully developed talents, such as being able to name the elevation of both the sun and the moon at any time of day, on any specified date; being able to name the day of the week for any date in the distant past or future (a talent known as calendrical calculation) and perfect pitch. Importantly, the abilities and the skills had to be exceptional by the standards of the general population, but also well above the individual's overall level of ability. In total, roughly 30 per cent had some kind of special ability (Philosophical Transactions of the Royal Society B, vol 364, p 1359).
  • For musical savants like Paravicini, Happé suggests that a bias towards small details might have led their developing brains to focus more on the exact notes than the overall melody, leading to perfect pitch and an exceptional musical memory. In art, a focus on small regions of a picture could lead to accurate perspective drawing.
  • Most people find this harder when they are shown an unsegmented version of the pattern versus a segmented one, but people with autism don't have this preference, demonstrating their skill at seeing a whole in terms of its parts even if there are no obvious dividing lines (see diagram). "It shows they are able to do the segmentation in their minds," says Winner. The precocious realists did not have this preference either, indicating a talent for realistic drawing may arise from this isolated trait commonly found in autism (Philosophical Transactions of the Royal Society B, vol 364, p 1449).
  • Although these results help to pinpoint exactly what it is about autism that predisposes people to talent, it's still not clear why an eye for detail is more common in autistic people in the first place. Clues might lie in the work of Simon Baron-Cohen from the University of Cambridge, which suggests that people with autism are "hypersensitive" to sensory information
  • Daniel Tammet, a prodigious savant who has memorised pi to 22,514 digits, believes his own talents have arisen from a special ability to connect different pieces of information together. "Savant abilities are linked to a highly associative type of thinking, an extreme form of a kind that everyone does - examples would include daydreaming, puns and the use of metaphors," he says.
  • The few studies of savant brains certainly suggest they are physically different from the average brain. For example, when Happé and Wallace studied the brain of a savant gifted at art, calendrical calculation and memory, they found his cortex was thicker in the areas associated with visuospatial processing and calculation and thinner in other regions associated with social cognition, compared with people who were neither savants nor autistic. But whether these differences were innate or grew with lifelong practice was still unclear.
  • The answer to that question may come from an unlikely source - a study of London taxi drivers who have acquired an encyclopedic memory of the streets of London known as "the Knowledge". Given that taxi drivers must remember the layout of 25,000 streets and the location of thousands of places of interest, and retrieve the information instantaneously, some researchers like Happé believe the Knowledge qualifies as a savant-like skill.
  • Eleanor Maguire and colleagues at the Institute of Neurology at University College London and colleagues found that drivers with the Knowledge have a bigger rear hippocampus than bus drivers and adults who do not drive taxis. In addition, the hippocampus appears to be larger the longer a taxi driver has been working, and shrinks once they retire (Philosophical Transactions of the Royal Society B, DOI: 10.1098/rstb.2008.0288).
  • In fact, it seems the remaining mystery is not so much how savants achieve their talents, but what drives them in the first place. "Motivation is a big unknown," says Wallace. "It's an enormous driving force in giftedness and in savants, but we don't know a lot about it."
  • One person who has something of an inside view on what contributes to savant ability is Paravicini's mentor, Adam Ockelford, a professor of music at Roehampton University in London who has watched Paravicini's talent blossom since the age of 4. When they first met, Paravicini was entirely self-taught and bashed at his plastic keyboard with his fists and elbows to reproduce the sounds he was hearing. It was only after years of practice that his technical skills developed.
  • But as researchers like Wallace have suggested, Paravicini seemed motivated way beyond the average music student. In fact, he seemed to be playing as if his life depended on it, and Ockelford thinks it's this that truly sets savants apart from their peers. "The survival instinct gets turned with extraordinary force into something else - in Derek's case music," says Ockelford. "When people see Derek, they think it is amazing, almost religious. But to me, it's mainly just hard work."
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    But now researchers are beginning to unearth clues as to how savants' formidable brains work, and that in turn is changing our view of what it means to be a savant.
Tero Toivanen

A Radical New Autism Theory - Page 1 - The Daily Beast - 0 views

  • . As posited by Henry and Kamila Markram of the Swiss Federal Institute of Technology in Lausanne, suggests that the fundamental problem in autism-spectrum disorders is not a social deficiency, but rather an hypersensitivity to experience, which includes an overwhelming fear response.
  • “There are those who say autistic people don’t feel enough,” says Kamila Markram. “We’re saying exactly the opposite: They feel too much.” Virtually all people with ASD report various types of oversensitivity and intense fear
  • “I think most people with ASD feel emotional empathy and care about the welfare of others very deeply.”
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  • A groundbreaking study suggests people with autism-spectrum disorders such as Asperger’s do not lack empathy—rather they feel others’ emotions too intensely to cope.
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    A groundbreaking study suggests people with autism-spectrum disorders such as Asperger's do not lack empathy-rather they feel others' emotions too intensely to cope.
Tero Toivanen

News from the Associated Press - newsjournalonline.com - 0 views

  • Leo Lytel was diagnosed with autism as a toddler. But by age 9 he had overcome the disorder. His progress is part of a growing body of research that suggests at least 10 percent of children with autism can "recover" from it - most of them after undergoing years of intensive behavioral therapy.
  • She presented research this week at an autism conference in Chicago that included 20 children who, according to rigorous analysis, got a correct diagnosis but years later were no longer considered autistic.
  • Skeptics question the phenomenon, but University of Connecticut psychology professor Deborah Fein is among those convinced it's real.
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  • Previous studies have suggested between 3 percent and 25 percent of autistic kids recover. Fein says her studies have shown the range is 10 percent to 20 percent.
  • But even after lots of therapy - often carefully designed educational and social activities with rewards - most autistic children remain autistic. Recovery is "not a realistic expectation for the majority of kids," but parents should know it can happen, Fein said.
  • The children in Fein's study, which is still ongoing, were diagnosed by an autism specialist before age 5 but no longer meet diagnostic criteria for autism. The initial diagnoses were verified through early medical records.
  • The researchers are also doing imaging tests to see if the recovered kids' brains look more like those of autistic or nonautistic children.
  • Imaging scans also are being done to examine brain function in formerly autistic kids.
  • Results from those tests are still being analyzed.
  • Most of the formerly autistic kids got long-term behavior treatment soon after diagnosis, in some cases for 30 or 40 hours weekly.
  • Many also have above-average IQs and had been diagnosed with relatively mild cases of autism. At age 2, many were within the normal range for motor development, able to walk, climb and hold a pencil.
  • Significant improvement suggesting recovery was evident by around age 7 in most cases, Fein said.
  • None of the children has shown any sign of relapse. But nearly three-fourths of the formerly autistic kids have had other disorders, including attention-deficit problems, tics and phobias; eight still are affected.
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    Leo Lytel was diagnosed with autism as a toddler. But by age 9 he had overcome the disorder. His progress is part of a growing body of research that suggests at least 10 percent of children with autism can "recover" from it - most of them after undergoing years of intensive behavioral therapy.
Tero Toivanen

Asperger Syndrome Tied to Low Cortisol Levels - 0 views

  • Low levels of a stress hormone may be responsible for the obsession with routine and dislike for new experiences common in children with a certain type of autism.
  • The body produces cortisol, among other hormones, in stressful situations. Cortisol increases blood pressure and blood sugar levels, among other duties, to signal the body's need to adapt to changes occurring around it.
  • People with Asperger syndrome notably have very repetitive or narrow patterns of thought and behavior, such as being obsessed with either a single object or topic. Though tending to become experts in this limited domain, they have otherwise very limited social skills, according to the study.
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  • "Although these are early days, we think this difference in stress hormone levels could be really significant in explaining why children with AS are less able to react and cope with unexpected change,"
  • If these Asperger symptoms are caused primarily by stress, caregivers could learn to steer children away from situations that would add to anxiety, the researchers said.
  • "This study suggests that children with AS may not adjust normally to the challenge of a new environment on waking,"
  • The researchers, whose findings were published in the journal Psychoneuroendocrinology, will next study if this lack of cortisol upon waking also occurs in children with other types of autism.
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    Low levels of a stress hormone may be responsible for the obsession with routine and dislike for new experiences common in children with a certain type of autism.
Tero Toivanen

Harvey Karp: Cracking the Autism Riddle: Toxic Chemicals, A Serious Suspect in the Auti... - 0 views

  • One group of substances of particular concern is a ubiquitous family of hormone twisting compounds, known as endocrine disrupting chemicals (EDCs).
  • Our exposure to EDCs is no mere theoretical concern. In 2000, a Centers for Disease Control (CDC) study found detectable phthalates in 99.9% of adults including women of childbearing age.
  • there is evidence that even minuscule amounts of these chemicals -- levels commonly present in a woman's body -- may disturb fetal brain development during highly sensitive periods of neural development known as windows of vulnerability.
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  • Our increasing exposure to EDCs lends support to a new hypothesis about the cause of autism, called the "extreme male theory." This theory, proposed by Dr. Simon Baron-Cohen and colleagues, speculates that autism is caused by something changing a fetus' hormonal balance that then leads to over-masculinization of the developing brain. Could that "something" be the slurry of hormone-altering chemicals we're exposed to every day? Are EDCs the reason autism-type disorders are 4-9 times more common in boys? (Vaccine side effects never show such lopsided impact on boys versus girls...a glaring fact that is totally ignored by those promoting the vaccine theory of autism.)
  • Here is where the very interesting link to EDCs comes into play: EDCs often act as weak estrogens and estrogen feminizines the body, but in a fetus' developing brain estrogen actually has the opposite effect...it causes masculinization.
  • The NCS will establish over one hundred study centers across the US to test the blood of 100,000 newborns for scores of synthetic chemicals, including many EDCs. (Workers have already begun going door-to-door enrolling pregnant moms into the program.) For the next 21 years, scientists will carefully follow the children's health, comparing the body burden of chemicals at birth to diseases developed later in life.
  • Within 3-4 years, we expect to have enough data accumulated to start detecting what chemicals might be linked to autism.
  • Beside the NCS, I support other new studies to look at: 1) the autism risk in vaccinated vs. unvaccinated kids; 2) the metabolism of vaccine ingredients (like aluminum, added to make shots work better), 3) more accurate determinations of the true incidence of autism.
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    The presence of EDCs in women of child-bearing age is especially worrisome. That is because there is evidence that even minuscule amounts of these chemicals -- levels commonly present in a woman's body -- may disturb fetal brain development during highly sensitive periods of neural development known as windows of vulnerability.
Tero Toivanen

Common Treatment Ineffective for Autism | Brain Blogger - 0 views

  • The selective serotonin reuptake inhibitors (SSRIs) are among the most widely used drugs for autism treatment, even though the effectiveness to date has been questionable. A new study published in the June issue of Archives of General Psychiatry reports that, not only are SSRIs ineffective, they may actually cause unintended side effects.
  • At the conclusion of the trial, nearly one-third (32.9%) of the patients receiving citalopram showed improvement in symptoms, but this was not significantly different from the 34.2% of patients who showed symptom improvement with placebo. Further, patients receiving citalopram were more likely to experience side effects, including nightmares, increased energy level, impulsiveness, decreased concentration, hyperactivity, diarrhea, insomnia, and dry skin than patients receiving placebo.
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    The selective serotonin reuptake inhibitors (SSRIs) are among the most widely used drugs for autism treatment, even though the effectiveness to date has been questionable. A new study published in the June issue of Archives of General Psychiatry reports that, not only are SSRIs ineffective, they may actually cause unintended side effects.
Tero Toivanen

The link between autism and extraordinary ability | Genius locus | The Economist - 0 views

  • A study published this week by Patricia Howlin of King’s College, London, reinforces this point. It suggests that as many as 30% of autistic people have some sort of savant-like capability in areas such as calculation or music.
  • Francesca Happé of King’s College, London, is one of them. As she observes, obsessional interests and repetitive behaviours would allow someone to practice, albeit inadvertently, whichever skill they were obsessed by. Malcolm Gladwell, in a book called “Outliers” which collated research done on outstanding people, suggested that anyone could become an expert in anything by practising for 10,000 hours. It would not be hard for an autistic individual to clock up that level of practice for the sort of skills, such as mathematical puzzles, that many neurotypicals would rapidly give up on.
  • Simon Baron-Cohen, a doyen of the field who works at Cambridge University, draws similar conclusions. He suggests the secret of becoming a savant is “hyper-systematising and hyper-attention to detail”. But he adds sensory hypersensitivity to the list. His team have shown one example of this using what is known as the Freiburg visual acuity and contrast test, which asks people to identify the gap in a letter “c” presented in four different orientations. Those on the autistic spectrum do significantly better at this than do neurotypicals. That might help explain Dr Happé’s observations about coins and raindrops.
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  • The upshot of these differences is that the columns in an autistic brain seem to be more connected than normal with their close neighbours, and less connected with their distant ones. Though it is an interpretative stretch, that pattern of connection might reduce a person’s ability to generalise (since disparate data are less easily integrated) and increase his ability to concentrate (by drawing together similar inputs).
  • Dr Snyder argues that savant skills are latent in everyone, but that access to them is inhibited in non-savants by other neurological processes. He is able to remove this inhibition using a technique called repetitive transcranial magnetic stimulation.
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    A study published this week by Patricia Howlin of King's College, London, reinforces this point. It suggests that as many as 30% of autistic people have some sort of savant-like capability in areas such as calculation or music. Moreover, it is widely acknowledged that some of the symptoms associated with autism, including poor communication skills and an obsession with detail, are also exhibited by many creative types, particularly in the fields of science, engineering, music, drawing and painting.
Tero Toivanen

Autism Vaccines - Mercury and Autism Vaccines - 1 views

  • The type of mercury used in thimerosal is generally cleared from the body within six weeks, which in theory would render it harmless. But according to those researchers who believe that the preservative causes autism, babies born during that 20-year window were injected with many times the "safe" level as determined by the FDA -- and some, they feel, were genetically incapable of clearing the doses of mercury from their bodies. Mercury is, in fact, a neurotoxin, and the theory is that the recent leap in autism diagnoses can be directly tied to thimerosal.
  • In 2004, the Institute of Medicine undertook a comprehensive review of all the published literature on thimerosal and autism and concluded that the available evidence demonstrate that there was no link. The CDC launched a series of studies that examined the relationship between the incidence of autism and the amount of mercury a child received in the first 6 months of life and also found no relationship. Although all published credible studies have found no link between thimerosal and autism, some continue to be unconvinced.
  • At present, the thimerosal controversy continues, even though the removal of thimerosal from vaccines has not resulted in lower rates of autism diagnoses.
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    At present, the thimerosal controversy continues, even though the removal of thimerosal from vaccines has not resulted in lower rates of autism diagnoses. Parents who continue to be concerned should be aware that thimerosal has now been removed from most vaccines -- and thimerosal-free vaccines are available across the board.
Tero Toivanen

Researchers from the CHUM Research Centre (CRCHUM) have iden - 0 views

  • The results show for the first time the role of the SYN1 gene in autism, in addition to epilepsy, and strengthen the hypothesis that a deregulation of the function of synapse because of this mutation is the cause of both diseases
  • until now, no other genetic study of humans has made this demonstration.
  • The different forms of autism are often genetic in origin and nearly a third of people with autism also suffer from epilepsy.
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  • Although mutations in other genes involved in the development of synapses (the functional junction between two neurons) have previously been identified, this mechanism has never been proved in epilepsy in humans until the present study.
  • The results of the present study were published in the latest online edition of Human Molecular Genetics.
Tero Toivanen

Oxytocin improves brain function in children with autism - 1 views

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    "Preliminary results from an ongoing, large-scale study by Yale School of Medicine researchers shows that oxytocin -- a naturally occurring substance produced in the brain and throughout the body -- increased brain function in regions that are known to process social information in children and adolescents with autism spectrum disorders (ASD)."
Graeme Wadlow

Interventions to Improve Communication in Autism - 0 views

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    Interventions to Improve Communication in Autism Child and Adolescent Psychiatric Clinics of North America Volume 17, Issue 4, October 2008, Pages 835-856 Treating Autism Spectrum Disorders Rhea Paul PhD, Yale Child Study Center
Tero Toivanen

Autism Research Blog: Translating Autism: Eyes aversion in autism may affect face recog... - 0 views

  • A brief review of Annaz, D., Karmiloff-Smith, A., Johnson, M., & Thomas, M. (2009). A cross-syndrome study of the development of holistic face recognition in children with autism, Down syndrome, and Williams syndrome Journal of Experimental Child Psychology, 102 (4), 456-486 DOI: 10.1016/j.jecp.2008.11.005
  • 33 kids with autism
  • 15 children with Williams syndrome
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  • 15 children with down’s syndrome
  • 25 typically developing children
  • The authors found that all three diagnostic groups showed anomalies in the development of face recognition when compared to typically developing kids.
  • The children with low (but not high) functioning autism show a disadvantage for identifying eyes but an advantage for identifying mouths. In addition, they were better at identifying eyes and noses when the these were upside down than when they were upside up. This is the opposite of what is expected in typically developing children.
  • The authors discussed how this may be due to an aversion to looking directly at eyes, especially in upright faces. Therefore, the observed deficiencies in face recognition among the low functioning autism group may not be due to problems in the development of whole face recognition processes per se, but instead this weakness may be due to a natural aversion to stare at the eyes area of the face.
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    Eyes aversion in autism may affect face recognition
Tero Toivanen

Autism Research Blog: Translating Autism: Vision problems in autism: Reduced convergence? - 0 views

  • The authors found that 11% of the typically developing children and 31% of the ASD had a documented visual impairment (myopia, astigmatism, etc). This difference was statistically significant. That is, children with ASD were significantly more likely than typically developing children to have these conditions. Children with autism also displayed significantly poorer visual acuity (but within normal limits), and lower convergence. Convergence refers to the process by which the eyes move towards each other to maintain focus on approaching or close-range objects.
  • The findings of reduced visual acuity in children with autism when compared to typically developing children contradict previous studies that have shown enhanced visual acuity in autism. This brings us to a major limitation of this study that was correctly noted by the authors.
  • Limited convergence therefore would be associated with more limited depth perception. I find this intriguing because the neuropsychological profile of children with high functioning autism is often very similar to what is observed in kids with non-verbal learning disabilities (including relative weaknesses in motor-visual functioning). In addition, many parents with children with ASD report that their kids have trouble with sports and other physical activities. I thus wonder how much the reduced convergence observed in ASD may affect the motor-visual functioning in autism.
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  • Clinically, I was also intrigued by the high rates of vision problems found among the ASD group. Although, as I mentioned, this may be due to a self-selection of the parents who agreed to participate, this is consistent with data suggesting that children with developmental disorders are more likely to have visual problems than typically developing children
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    Analysis of visual functioning in children with autism suggests impairment in visual convergence. A brief review of: Elizabeth Milne, Helen Griffiths, David Buckley, Alison Scope (2009). Vision in Children and Adolescents with Autistic Spectrum Disorder: Evidence for Reduced Convergence Journal of Autism and Developmental Disorders DOI: 10.1007/s10803-009-0705-8
Tero Toivanen

Easter Seals and Autism » Blog Archive » Looking for hard evidence on P.L.... - 1 views

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    Study to determine the effectiveness of P.L.A.Y. and DIR Floortime intervention strategy designed to meet the intensive needs of children with autism spectrum disorders.
Tero Toivanen

Genes implicated in twins' autism | The Autism News - 1 views

  • Researchers have known for years that when one identical twin has autism, the other is also likely to be diagnosed with it – evidence that autism likely has a genetic component.
  • Researchers at Kennedy Krieger Institute studied 277 pairs of twins and found that when one identical twin had the disorder, the other developed it 88 percent of the time; for fraternal twins, that figure was 31 percent.
  • Despite this progress in unlocking the mysteries of autism, scientists have simply confirmed that there are likely numerous genetic links to autism.
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  • Each discovery explains just a tiny fraction of autism’s causes. Researchers think the great majority – 90 percent – of autism cases have a genetic cause, but they’ve found fewer than 10 percent of the triggers.
  • researchers have found about 50 genes so far that might be tied to autism, which explain very few cases, he said.
  • Autism isn’t one disease; it’s too individual to locate just one genetic cause. It’s not like cystic fibrosis, a disorder for which researchers have identified one gene – and tests to diagnose it.
  • autism researchers envision that a wide variety of gene defects are responsible for the symptoms collectively known as autism spectrum disorders. The disabilities, different in each child, range from the mild Asperger syndrome to more severe impairments in social interaction and communication.
  • “It’s going to take some work before we understand the true causes of autism,” he said. “We need to make much more headway to ever have enough understanding so that patient management and therapies can be improved.”
  • None of the new findings explains why more children are being diagnosed with autism. Genes, said Goldstein, tell only part of the story.
  • “The idea is there is an environmental interaction with the genetic component,” he said.
  • Autism may be inherited to some degree, but even twin studies show that not all sets of identical twins have autism. And when they do, they don’t always have the same severity of the disorder
  • That connection between genes and the environment, called epigenetics, might explain these distinctions
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    Researchers have known for years that when one identical twin has autism, the other is also likely to be diagnosed with it - evidence that autism likely has a genetic component.
Tero Toivanen

Facing Autism in New Brunswick: In Future Will Autism Spectrum Disorders Be Referred To... - 2 views

  • f brain connectivity is the biological problem that gives rise to autism disorders will  effective treatments and cures be developed targeting the connectivity issues?
  • 'People have started to look at autism as a developmental disconnection syndrome - there are either too many connections or too few connections between different parts of the brain,' says Sahin.
  • Sahin hopes that the brain's miswiring can be corrected by drugs targeting the molecular pathways that cause it.
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    If further study results indicate that autism deficits arise from brain connectivity disorders will the autism spectrum disorders come to be known as the Brain Connectivity Disorders?
Tero Toivanen

A week ago, a new study published in the Archives of General - 0 views

  • The Howard Hughes Medical Institute describes how researchers using "high-throughput gene sequencing technology" were able to identify several de novo or spontaneous gene mutations in 20 children with sporadic autism spectrum disorders -- that is, their family members showed no other sign of autism.
  • The team identified 21 spontaneous mutations -- meaning they weren't inherited from either parent -- in the children's DNA. Eleven of these were mutations that would alter the protein encoded by the affected gene. In four of the 20 children, the researchers found mutations that were severe, some of which have been previously linked to autism, intellectual disability, and epilepsy.
  • one child had a mutation in the GRIN2B gene, which is crucial for neuronal signaling.
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  • Another individual had an extra nucleotide in FOXP1, a gene that, along with its close relatives, has been heavily implicated in language defects.
  • These new findings support the 'multi-hit' model of autism, which suggests that having more than one mutation can cause or worsen symptoms of autism and other brain disorders. The different combinations of mutations may contribute to the heterogeneity in ASDs.
  • That such different combinations of genetic mutations contribute to a child being autistic could account for why individuals with an ASD diagnosis have some very similar, and very different, features.
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    "The Howard Hughes Medical Institute describes how researchers using "high-throughput gene sequencing technology" were able to identify several de novo or spontaneous gene mutations in 20 children with sporadic autism spectrum disorders -- that is, their family members showed no other sign of autism."
Tero Toivanen

Emotional, motivational and interpersonal responsiveness of children with autism in imp... - 0 views

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    The results of this exploratory study found significant evidence supporting the value of music therapy in promoting social, emotional and motivational development in children with autism.
Tero Toivanen

Journal of Neuropsychiatric Disease and Treatment - Dove Press - 0 views

  • These results suggest that nonverbal children have specifically impaired imitation and pointing skills.
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    This study evaluates the correlation between failure to develop spontaneous imitation and language skills in pervasive developmental disorders.
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