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shared by Tero Toivanen on 10 Jan 10 - Cached

Now, researchers led by Mustafa Sahin, MD, PhD, of Children's Department of Neurology, provide evidence that mutations in one of the TSC's causative genes, known as TSC2, prevent growing nerve fibers (axons) from finding their proper destinations in the developing brain.
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Sahin and colleagues showed that when mouse neurons were deficient in TSC2, their axons failed to land in the right places.
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Further investigation showed that the axons' tips, known as "growth cones," did not respond to navigation cues from a group of molecules called ephrins.
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Although the study looked only at retinal connections to the brain, the researchers believe their findings may have general relevance for the organization of the developing brain. Scientists speculate that in autism, wiring may be abnormal in the areas of the brain involved in social cognition.
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there are either too many connections or too few connections between different parts of the brain
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shared by Tero Toivanen on 16 Jan 10 - Cached

f brain connectivity is the biological problem that gives rise to autism disorders will  effective treatments and cures be developed targeting the connectivity issues?
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'People have started to look at autism as a developmental disconnection syndrome - there are either too many connections or too few connections between different parts of the brain,' says Sahin.
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Sahin hopes that the brain's miswiring can be corrected by drugs targeting the molecular pathways that cause it.
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