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Tero Toivanen

Why parents swear by ineffective treatments for autism. - By Sydney Spiesel - Slate Mag... - 0 views

www.slate.com/2215076

autism ineffective treatments treatment

shared by Tero Toivanen on 02 Apr 09 - Cached
  • Since most of the ways we diagnose autism are based on behavior, we can't rely on biological, structural, or chemical findings to determine if a treatment is working. We primarily measure success based on a patient's change, or lack thereof, in behavior.
  • The behavioral changes produced by the few effective treatments make life in social settings (including the home) possible, but we have no idea whether they have any effect on the underlying cause (or causes) of autism or whether they even make severely affected patients feel better.
  • One method intended to help, "facilitated communication," is based on the idea that a sensitive facilitator will hold the hand of a patient over a kind of Ouija board. She will then help the patient respond to questions by sensing his intention and helping guide his hand to spell out answers. Rigorous studies have shown that the spelled-out answers come from the unconscious (or, worse, the conscious) mind of the facilitator. Nonetheless, the practice is still in use, and I know parents who are utterly convinced that it is valid and useful. Frankly, something important did happen when facilitated communication was introduced to my patients: They improved, they brightened, they became more social and more interactive, and they seemed, somehow, happier, even though facilitated communication didn't actually translate their thoughts into words. I'll come back to "why" in a minute.
  • ...4 more annotations...
  • The techniques of sensory integrative treatment include rubbing or brushing skin (using graded and tactile stimulation), balance exercises, exposure to soft music, and the use of weighted clothes, among other things. Does it work? Most of the research has been of very poor quality, but, in virtually all of the recent studies, sensory integration doesn't seem to be any more beneficial than any other treatment.
  • It looks as if environmental alteration, especially if coupled with increased attention and perhaps expectation, often leads to change in human behavior. It's called the "Hawthorne effect."
  • People respond—mostly favorably—to positive attention and interaction. The question we need to ask about all the treatments available for autism is whether they actively shape and change brain development and thus treat the underlying condition, as many proponents believe, or whether the benefits (if they are present at all) are simply another example of the Hawthorne effect.
  • Perhaps my patients who became more alive and more interactive after facilitated communication was introduced changed because their families and caretakers were taking them more seriously as people who might have an inner life—people worthy of attention and interaction.
  • Tero Toivanen on 02 Apr 09
     
    People respond-mostly favorably-to positive attention and interaction. The question we need to ask about all the treatments available for autism is whether they actively shape and change brain development and thus treat the underlying condition, as many proponents believe, or whether the benefits (if they are present at all) are simply another example of the Hawthorne effect.
Graeme Wadlow

Following Gaze: Gaze-Following Behavior as a Window into Social Cognition - 0 views

www.ncbi.nlm.nih.gov/...PMC2859805

attention orienting social attention joint attention shared attention theory of mind

shared by Graeme Wadlow on 04 Jan 12 - No Cached
  • Graeme Wadlow on 04 Jan 12
     
    Following Gaze: Gaze-Following Behavior as a Window into Social Cognition
Tero Toivanen

New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible - 0 views

www.sciencedaily.com/...090401145312.htm

autism new theory brain

shared by Tero Toivanen on 02 Apr 09 - Cached
  • the brains of people with autism are structurally normal but dysregulated, meaning symptoms of the disorder might be reversible.
  • autism is a developmental disorder caused by impaired regulation of the locus coeruleus, a bundle of neurons in the brain stem that processes sensory signals from all areas of the body.
  • The new theory stems from decades of anecdotal observations that some autistic children seem to improve when they have a fever, only to regress when the fever ebbs.
  • ...11 more annotations...
  • This study documented that autistic children experience behavior changes during fever.
  • Einstein researchers contend that scientific evidence directly points to the locus coeruleus–noradrenergic (LC-NA) system as being involved in autism. "The LC-NA system is the only brain system involved both in producing fever and controlling behavior," says co-author Dominick P. Purpura, M.D., dean emeritus and distinguished professor of neuroscience at Einstein.
  • The locus coeruleus has widespread connections to brain regions that process sensory information. It secretes most of the brain's noradrenaline, a neurotransmitter that plays a key role in arousal mechanisms, such as the "fight or flight" response. It is also involved in a variety of complex behaviors, such as attentional focusing (the ability to concentrate attention on environmental cues relevant to the task in hand, or to switch attention from one task to another). Poor attentional focusing is a defining characteristic of autism.
  • "What is unique about the locus coeruleus is that it activates almost all higher-order brain centers that are involved in complex cognitive tasks," says Dr. Mehler.
  • autism, the LC-NA system is dysregulated by the interplay of environment, genetic, and epigenetic factors
  • They believe that stress plays a central role in dysregulation of the LC-NA system, especially in the latter stages of prenatal development when the fetal brain is particularly vulnerable.
  • a higher incidence of autism among children whose mothers had been exposed to hurricanes and tropical storms during pregnancy.
  • autistic children, fever stimulates the LC-NA system, temporarily restoring its normal regulatory function. "This could not happen if autism was caused by a lesion or some structural abnormality of the brain," says Dr. Purpura.
  • future of autism treatment probably lies in drugs that selectively target certain types of noradrenergic brain receptors or, more likely, in epigenetic therapies targeting genes of the LC-NA system.
  • If the locus coeruleus is impaired in autism, it is probably because tens or hundreds, maybe even thousands, of genes are dysregulated in subtle and complex ways," says Dr. Mehler. "The only way you can reverse this process is with epigenetic therapies, which, we are beginning to learn, have the ability to coordinate very large integrated gene networks."
  • "You can't take a complex neuropsychiatric disease that has escaped our understanding for 50 years and in one fell swoop have a therapy that is going to reverse it — that's folly. On the other hand, we now have clues to the neurobiology, the genetics, and the epigenetics of autism. To move forward, we need to invest more money in basic science to look at the genome and the epigenome in a more focused way."
  • Tero Toivanen on 02 Apr 09
     
    the brains of people with autism are structurally normal but dysregulated, meaning symptoms of the disorder might be reversible.
Graeme Wadlow

A review of neuropsychological and neuroimaging research in autistic spectrum... - 0 views

www.tara.tcd.ie/...Sanders%20RASD07.pdf

RP1 filetype:pdf media:document Autism ASD

shared by Graeme Wadlow on 04 Jan 12 - No Cached
  • Graeme Wadlow on 04 Jan 12
     
    Article in Press A review of neuropsychological and neuroimaging research in autistic spectrum disorders: Attention, inhibition and cognitive flexibilitywww.tara.tcd.ie/bitstream/2262/29986/1/Sanders RASD07.pdf
Tero Toivanen

Autism disorders might be reversible. | - I Teach Autism.com - - 0 views

www.iteachautism.com/...-or-disorder-may-be-reversible

autism fever epigenetics locus coeruleus brain neurobiology LC-NA system theory Albert Einstein College

shared by Tero Toivanen on 08 Jun 09 - Cached
  • Scientists at Albert Einstein College of Medicine of Yeshiva University have proposed a sweeping new theory of autism that suggests that the brains of people with autism are structurally normal but dysregulated, meaning symptoms of the disorder might be reversible.
  • The central tenet of the theory, published in the March issue of Brain Research Reviews, is that autism is a developmental disorder caused by impaired regulation of the locus coeruleus, a bundle of neurons in the brain stem that processes sensory signals from all areas of the body.
  • The new theory stems from decades of anecdotal observations that some autistic children seem to improve when they have a fever, only to regress when the fever ebbs.
  • ...8 more annotations...
  • Einstein researchers contend that scientific evidence directly points to the locus coeruleus–noradrenergic (LC-NA) system as being involved in autism. “The LC-NA system is the only brain system involved both in producing fever and controlling behavior,” says co-author Dominick P. Purpura, M.D., dean emeritus and distinguished professor of neuroscience at Einstein.
  • The locus coeruleus has widespread connections to brain regions that process sensory information.
  • It is also involved in a variety of complex behaviors, such as attentional focusing (the ability to concentrate attention on environmental cues relevant to the task in hand, or to switch attention from one task to another).
  • “What is unique about the locus coeruleus is that it activates almost all higher-order brain centers that are involved in complex cognitive tasks,” says Dr. Mehler.
  • Drs. Purpura and Mehler hypothesize that in autism, the LC-NA system is dysregulated by the interplay of environment, genetic, and epigenetic factors (chemical substances both within as well as outside the genome that regulate the expression of genes). They believe that stress plays a central role in dysregulation of the LC-NA system, especially in the latter stages of prenatal development when the fetal brain is particularly vulnerable.
  • Drs. Purpura and Mehler believe that, in autistic children, fever stimulates the LC-NA system, temporarily restoring its normal regulatory function.
  • the future of autism treatment probably lies in drugs that selectively target certain types of noradrenergic brain receptors or, more likely, in epigenetic therapies targeting genes of the LC-NA system.
  • “You can’t take a complex neuropsychiatric disease that has escaped our understanding for 50 years and in one fell swoop have a therapy that is going to reverse it — that’s folly. On the other hand, we now have clues to the neurobiology, the genetics, and the epigenetics of autism. To move forward, we need to invest more money in basic science to look at the genome and the epigenome in a more focused way.”
  • Tero Toivanen on 08 Jun 09
     
    Scientists at Albert Einstein College of Medicine of Yeshiva University have proposed a sweeping new theory of autism that suggests that the brains of people with autism are structurally normal but dysregulated, meaning symptoms of the disorder might be reversible.
Tero Toivanen

About The Ability of Asperger Syndrome Children to Hyper-Focus | - I Teach Autism.com - - 0 views

www.iteachautism.com/...ndrome-children-to-hyper-focus

autism Asperger's Syndrome learning classroom education tool hyper-focusing

shared by Tero Toivanen on 13 Jul 09 - Cached
  • The Asperger Syndrome hyper-focusing trait can be helpful in a classroom setting when educators choose to use this extreme attention span as a tool.
  • If normal classroom learning procedures are not getting through to an AS child, try working with the theme that they are already working with. As an example, a few words about their chosen object mentioned during a history lesson, can perhaps make the entire history lesson memorable.
  • the Asperger Syndrome hyper-focus ability is a learning style. AS children have the ability to hyper-focus their way into learning traditional subjects.
  • Tero Toivanen on 13 Jul 09
     
    The Asperger Syndrome hyper-focusing trait can be helpful in a classroom setting when educators choose to use this extreme attention span as a tool.
Graeme Wadlow

Shared heritability of attention-deficit/hyperactivity disorder and autism spe... - 0 views

www.springerlink.com/...32100451q60g3q13

RP1 attn autm SpringerLink Autism ASD Molecular genetics Shared heritability Attention-Deficit_Hyperactivity Disorder ADHD

shared by Graeme Wadlow on 04 Jan 12 - No Cached
  • Graeme Wadlow on 04 Jan 12
     
    SpringerLink - European Child & Adolescent Psychiatry, Volume 19, Number 3
Tero Toivanen

Autism Research Blog: Translating Autism: Language and Autism: Do kids with autism make... - 0 views

www.translatingautism.com/...and-autism-grammaticality.html

autism

shared by Tero Toivanen on 12 Mar 09 - No Cached
  • The ASD performed worse than the typically developing group across the entire grammaticality judgment task. However, the authors noted that the groups did NOT differ when the sentences were short or medium length. That is, the apparent relative weaker performance among the ASD group was mostly during long sentences. In addition, these group differences were more pronounced when the error was located at the end of long sentences. This indicates that the group differences may be due to difficulty in working memory and attention among the autism group.
  • However, it is unlikely that these findings are only attributable to working memory problems. Specifically, the ASD groups showed impaired performance only to some type grammatical errors but not others. That is, the ASD group had difficulty identifying omissions and substitution errors, but did not show difficulty identifying order or insertion errors. This suggests that attention and working memory difficulties interact with some unique deficits in grammaticality judgment.
  • Tero Toivanen on 12 Mar 09
     
    Autism Research Blog: Translating Autism: Language and Autism: Do kids with autism make grammatical errors when sentences are long?
Tero Toivanen

Eide Neurolearning Blog: Recess Essential for Improving Attention - 0 views

eideneurolearningblog.blogspot.com/...s-essential-for-improving.html

neurolearning recess learning behavior

shared by Tero Toivanen on 02 Mar 09 - Cached
  • New research suggests that play and down time may be as important to a child’s academic experience as reading, science and math, and that regular recess, fitness or nature time can influence behavior, concentration and even grades.
  • Young children with sensory processing disorders are especially susceptible to behavioral and attention problems if they are not allowed to move and exercise throughout their day.
  • Tero Toivanen on 02 Mar 09
     
    New research suggests that play and down time may be as important to a child's academic experience as reading, science and math, and that regular recess, fitness or nature time can influence behavior, concentration and even grades.
Tero Toivanen

Autism Therapies and Outcomes -- Outcomes and Autism - 0 views

autism.about.com/...abachoice_8.htm

autism therapy behavior progress learning

shared by Tero Toivanen on 10 Dec 09 - Cached
  • The view of the behavior analyst should be that the subject is always right. If the child isn't learning, you need to know why. It's not that the child is defective, it's that the approach isn't working. The therapist needs to ask, "what do I need to do to teach this child?" ...Being autistic shouldn't stop children from learning. It has nothing to do with their ability to learn. They just don't learn typically. That's the problem we have. You can't use "autism" as way to explain behaviors: it is the behaviors. Why do the behaviors occur? We don't always know. But that doesn't mean we can't teach children with autism language and social interaction. They don't need us to have fun -- they can create their own reinforcers. The therapist has to find a reinforcer that's better than what the child can do on his own. That "better thing" should always have a social component.
  • Tero Toivanen on 10 Dec 09
     
    It's important to remember that, when it comes to therapy for children with autism, failure to progress is never the fault of the child. If you hear from a therapist that your child doesn't progress because of his behaviors, attention span, intelligence level, or stubbornness, it's time to question the therapist's technique.
Tero Toivanen

12 Tips to Setting up an Autism Classroom « Principal Kendrick - 6 views

kendrik2.wordpress.com/...setting-up-an-autism-classroom

autism special education special needs students SPED ASD:teaching classroom ASD:educators tips

shared by Tero Toivanen on 30 Dec 10 - Cached
  • In a world that’s ever changing, routine and structure provide great comfort to a child on the autism spectrum.  Define routines clearly. 
  • Activities are successful when they’re broken into small steps.
  • Make sure children know what to do if they finish ahead of time.  Typically, children with autism do not use free time productively; therefore strive to have as little downtime between activities as possible.
  • ...47 more annotations...
  • 2. Use visuals
  • Remember to keep explanations simple and short about each picture or concentration will wane.   Give written instructions instead of verbal whenever you can.  Highlight or underline any text for emphasis.
  • People with autism like order and detail.  They feel in control and secure when they know what to expect
  • Picture schedules are even more powerful because they help a student visualize the actions.
  • Make sure you have this schedule in a very visible place in your classroom and direct the students’ attention to it frequently, particularly a few minutes before you begin the next activity.
  • Written schedules are very effective for good readers.  These can also be typed up and placed on a student’s desk.
  • 4. Reduce distractions
  • Many people with autism find it difficult to filter out background noise and visual information.  Children with autism pay attention to detail.  Wall charts and posters can be very distracting. 
  • Try and seat children away from windows and doors. 
  • 5. Use concrete language
  • Always keep your language simple and concrete.   Get your point across in as few words as possible. 
  • Avoid using idioms.
  • Give very clear choices and try not to leave choices open ended.  You’re bound to get a better result by asking “Do you want to read or draw?” than by asking “What do you want to do now?”
  • 6. It’s not personal
  • Children with autism are not rude.  They simply don’t understand social rules or how they’re supposed to behave.
  • NEVER, ever, speak about a child on the autism spectrum as if they weren’t present
  • Despite the lack of reaction they sometimes present, hearing you speak about them in a negative way will crush their self esteem.
  • 7. Transitions
  • Children on the autism spectrum feel secure when things are constant.  Changing an activity provides a fear of the unknown.  This elevates stress which produces anxiety
  • Reduce the stress of transitions by giving ample warning
  • Using schedules helps with transitions too as students have time to “psyche themselves up” for the changes ahead.
  • People can be slow when they are learning a new skill until they become proficient
  • Encourage your students to ask each other for help and information
  • Making decisions is equally important and this begins by teaching students to make a choice.  Offer two choices. 
  • When giving a directive or asking a question, make sure you allow for extra processing time before offering guidance.  Self help skills are essential to learn
  • Never underestimate the power of consistency.
  • Avoid this temptation and make sure you allow ample time before you abandon an idea.  Remember that consistency is a key component of success.  If you’re teaching a student to control aggression, the same plan should be implemented in all settings, at school and at home.
  • 9. Rewards before consequences
  • We all love being rewarded and people with autism are no different.  Rewards and positive reinforcement are a wonderful way to increase desired behavior
  • If possible, let your students pick their own reward so they can anticipate receiving it.
  • There are many reward systems which include negative responses and typically, these do not work as well.
  • Focusing on negative aspects can often lead to poor results and a de-motivated student.  When used correctly, rewards are very powerful and irresistible
  • Every reward should be showered in praise.  Even though people on the spectrum might not respond typically when praised, they enjoy it just as much as you!
  • 10. Teach with lists
  • Teaching with lists sets clear expectations.  It defines a beginning, middle and an end.
  • People on the autism spectrum respond well to order and lists are no exception.  Almost anything can be taught in a list format.
  • While typical people often think in very abstract format, people on the spectrum have a very organized way of thought.  Finding ways to work within these parameters can escalate the learning curve.    
  • 11. Creative teaching
  • It helps to be creative when you’re teaching students with autism.  People on the spectrum think out of the box and if you do too, you will get great results.
    • Tero Toivanen
      Tero Toivanen on 30 Dec 10
       
      Exactly!
  • Often, people with autism have very specific interests.  Use these interests as motivators.
    • Tero Toivanen
      Tero Toivanen on 30 Dec 10
       
      This is how I work! It's works!
  • Another great strategy to use is called “Teaching with questions”.  This method keeps students involved, focused and ensures understanding.
  • Another great way of teaching is by adding humor to your lessons.  We all respond to humor.
    • Tero Toivanen
      Tero Toivanen on 30 Dec 10
       
      When you feel well, your students feel well also and learn better!
  • 12. Don’t sweat the small stuff
  • The final goal is for children to be happy and to function as independently as possible.
  • Don’t demand eye contact if a student has trouble processing visual and auditory information simultaneously.
    • Tero Toivanen
      Tero Toivanen on 30 Dec 10
       
      It may even be painful for the student... There are research about this issue.
  • By correcting every action a person does, you’re sending a message that they’re not good enough the way they are.  When making a decision about what to correct, always ask yourself first, “Will correcting this action help this person lead a productive and happy life?”
Tero Toivanen

Sensory Friendly Classrooms with Dr. Roya Ostovar - The SPD Blogger Network - 3 views

www.spdbloggernetwork.com/...lassrooms-with-dr-roya-ostovar

classrooms sensory friendly accommodations school SPD special education special needs SPED classroom autism

shared by Tero Toivanen on 01 Apr 11 - No Cached
  • Having sensory friendly settings is common sense and it benefits everyone, all students and learners as well as teachers and staff. Changing the classroom also teaches all students how to find practical and adaptive ways of making their setting work for them to allow for optimal learning and functioning, a skill that is beneficial to everyone. It also makes more sense to change the environment to fit the child’s needs and not the other way around. Changing the classroom helps the child with SPD blend in with other students, and it is not isolating, or stigmatizing.
  • A sensory friendly classroom improves attention, concentration, ability to focus for longer periods of time, learning, social functioning, and it also reduces the overall level of stress
  • For more specific and multiple examples of the accommodations that can be made, a book I authored titled “The Ultimate Guide to Sensory Processing Disorder” offers a comprehensive guide.
  • ...8 more annotations...
  • Vision: Reduce/ eliminate clutter and visual distractions; modify assignments to be shorter; use a highlighter
  • Auditory: Reduce/eliminate distracting noise; play Mozart or calming music in the background when possible
  • Tactile: Allow students to use chalk on the board because it is more tactile rich
  • Olfactory: Use scented markers to wake kids up; have lavender lotion or soap; and avoid noxious odors in the classroom
  • Vestibular: Allow movement and breaks; offer therapy balls to sit on; Movin-Sit cushions benefit the whole classroom; stretch breaks, start class with movement activities
  • Properioception: Movement, Movin-Sit cushions, Brain Gym, Yoga, Chair push ups (i.e. sitting on hands and pushing up); chairs and tables at right height and positioned correctly
  • A sensory friendly classroom gets the kids with SPD and ASD ready to learn; improves the overall functioning of the child including learning, attention, concentration, social functioning, and behavioral presentation; and lowers their stress and anxiety levels
  • Two quick suggestions: 1) Simplify the classroom: Less is more. Take a minimalistic approach to setting up the room and; 2) Support all learning styles: Some kids learn through auditory channels, some visual, and some through kinesthetic and hands on activities. By the same token, incorporate activities that support the sensory channel and each child’s sensory profile
Tero Toivanen

Researchers define uniform method to interpret autism spectrum disorders - 2 views

www.physorg.com/news181832834.html

autism ASD research neuroscience Autism Spectrum Disorder

shared by Tero Toivanen on 05 Jan 10 - Cached
  • This approach makes it easier to understand both commonalities and differences between ASD and other conditions, such as Attention Deficit Hyperactivity Disorder (ADHD). This approach will make it possible to test predictions about the location of these brain networks, how they function differently in people with ASD and how to use this knowledge to design interventions and compensatory strategies.
  • A recent study of a U.S. metropolitan area estimates that 3.4 of every 1,000 children between 3 and 10 years-old have Autism.
  • Tero Toivanen on 05 Jan 10
     
    Dr. Dorit Ben Shalom recommends a uniform approach to evaluating and confronting the four common problems associated with ASD.
Tero Toivanen

An Apple for the Students | By Marcia Kaye | University of Toronto Magazine - 3 views

www.magazine.utoronto.ca/...ildren-autism-ipad-marcia-kaye

autism students special needs ipad ipads

shared by Tero Toivanen on 30 Apr 12 - No Cached
  • The two-year study, which ended last December, found that within six weeks the devices boosted kids’ attention spans, raised their ability to identify pictured objects by 45 to 60 per cent, and improved communication skills in these mostly nonverbal children by 20 per cent.
  • A surprising bonus: students who had never been sociable were suddenly requesting an iPad to initiate an activity with another student.
  • McEwen suggests that the devices’ appeal may lie in their multisensory nature, with images and sound – and vibration (thanks to the addition of a downloadable app). She adds that the device’s voice app, which is always calm and unemotional, appeals to those who thrive on consistency, including many children with ASD.
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  • One boy in kindergarten who had always ignored green “yes” and red “no” boxes on paper responded instantly to the identical boxes on the screen.
  • The iPad’s larger screen is better suited to children with vision or fine-motor challenges, such as the blind six-year-old in a wheelchair who delights in moving his arm across the tablet to create his own music.
  • Tero Toivanen on 30 Apr 12
     
    Autistic children develop better communications skills when using iPads, researcher finds
Graeme Wadlow

Talent in autism: hyper-systemizing, hyper-attention to detail and sensory hypersensiti... - 0 views

rstb.royalsocietypublishing.org/...1377.abstract

RP1 autm rstb.royalsocietypublishing Autism ASD

shared by Graeme Wadlow on 04 Jan 12 - No Cached
  • Graeme Wadlow on 04 Jan 12
     
    Philosophical Transactions B DMI Dec 2009 Baron-Cohen et al. 364 (1522): 1377
Graeme Wadlow

Explosive, oppositional, and aggressive behavior in children with autism compared to ot... - 0 views

www.sciencedirect.com/...S1750946711001450

RP1 autm attn ScienceDirect Attention-Deficit_Hyperactivity Disorder ADHD autism ASD Explosive; Oppositional; Aggressive;

shared by Graeme Wadlow on 04 Jan 12 - No Cached
  • Graeme Wadlow on 04 Jan 12
     
    ScienceDirect - Research in Autism Spectrum Disorders : Explosive, oppositional, and aggressive behavior in children with autism compared to other clinical disorders and typical children
Tero Toivanen

The Blog's First Question « Growing up on the Spectrum, the Blog - 0 views

growinguponthespectrum.com/...the-blogs-first-question

autism spectrum

shared by Tero Toivanen on 21 Mar 09 - Cached
  • I don’t have Lynn Koegel at my side so these are the answers of a mom who’s been through a lot of this and NOT of an autism expert who runs a clinic, so any mistakes I make are my own, not hers!
  • But the whole point of speech is to nail down that one-to-one correlation between the sound and the object it represents.
  • As far as the “up” thing goes, one thing that Lynn and I strongly agree on is that even though kids with special needs may at times require special attention, they also need to learn that the world doesn’t revolve around them–just like every kid needs to learn.
  • Tero Toivanen on 21 Mar 09
     
    The Blog's First Question « Growing up on the Spectrum, the Blog
Tero Toivanen

News from the Associated Press - newsjournalonline.com - 0 views

hosted.ap.org/...US_MED_AUTISM_RECOVERY

autism research behavioral therapy recover

shared by Tero Toivanen on 09 May 09 - Cached
  • Leo Lytel was diagnosed with autism as a toddler. But by age 9 he had overcome the disorder. His progress is part of a growing body of research that suggests at least 10 percent of children with autism can "recover" from it - most of them after undergoing years of intensive behavioral therapy.
  • She presented research this week at an autism conference in Chicago that included 20 children who, according to rigorous analysis, got a correct diagnosis but years later were no longer considered autistic.
  • Skeptics question the phenomenon, but University of Connecticut psychology professor Deborah Fein is among those convinced it's real.
  • ...10 more annotations...
  • Previous studies have suggested between 3 percent and 25 percent of autistic kids recover. Fein says her studies have shown the range is 10 percent to 20 percent.
  • But even after lots of therapy - often carefully designed educational and social activities with rewards - most autistic children remain autistic. Recovery is "not a realistic expectation for the majority of kids," but parents should know it can happen, Fein said.
  • The children in Fein's study, which is still ongoing, were diagnosed by an autism specialist before age 5 but no longer meet diagnostic criteria for autism. The initial diagnoses were verified through early medical records.
  • The researchers are also doing imaging tests to see if the recovered kids' brains look more like those of autistic or nonautistic children.
  • Imaging scans also are being done to examine brain function in formerly autistic kids.
  • Results from those tests are still being analyzed.
  • Most of the formerly autistic kids got long-term behavior treatment soon after diagnosis, in some cases for 30 or 40 hours weekly.
  • Many also have above-average IQs and had been diagnosed with relatively mild cases of autism. At age 2, many were within the normal range for motor development, able to walk, climb and hold a pencil.
  • Significant improvement suggesting recovery was evident by around age 7 in most cases, Fein said.
  • None of the children has shown any sign of relapse. But nearly three-fourths of the formerly autistic kids have had other disorders, including attention-deficit problems, tics and phobias; eight still are affected.
  • Tero Toivanen on 09 May 09
     
    Leo Lytel was diagnosed with autism as a toddler. But by age 9 he had overcome the disorder. His progress is part of a growing body of research that suggests at least 10 percent of children with autism can "recover" from it - most of them after undergoing years of intensive behavioral therapy.
Tero Toivanen

NeuroLogica Blog » The Genetics of Autism - 0 views

www.theness.com/neurologicablog

autism genetics

shared by Tero Toivanen on 03 May 09 - Cached
  • What this means is that there is likely to be a complex set of many factors that contribute to ASD - not one single cause.
  • The same exact situation is true for other entities, like schizophrenia and attention deficit disorder (ADD).
  • One difference, however, is that schizophrenia and ADD likely represent changes to particular parts of the brain, while autism is likely due to changes in the global architecture of the brain.
  • ...5 more annotations...
  • Getting back to the genetics of autism, current models are therefore consistent with what is being found when the genetics of autism is researched - researchers are finding many genes that predispose to autism in a subset of cases but no single or simple universal cause. At present, 133 different gene variants have been linked to autism.
  • This new research, conducted by Dr. Hakon Hakonarson of the Children’s Hospital of Philadelphia, is a genome wide analysis involving about 10,000 individuals.
  • The results are especially significant because the variants lie between two genes, called CDH9 and CDH10, which are known to play an important role in forming nerve connections in the brain.
  • The gene variants that correlated with ASD are for proteins that are involved in the process of neurons forming connections with each other. There is already other lines of evidence that suggest what is different in ASD brains is a decrease in the amount of interconnectedness and communication among neurons. It is therefore likely no coincidence that this study found genetic correlations for proteins involved with neuronal connections.
  • This also is compatible with the finding that many separate genes are potentially involved with ASD - for there are many separate genes and processes involved with forming and maintaining neuronal connections.
  • Tero Toivanen on 03 May 09
     
    A new genome-wide analysis of families with autism has found significant gene associations, adding to the growing evidence for strong genetic contribution to autism.
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