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Dakota Declue

New plan of attack in cancer fight: Two-drug combination, under certain circumstances, ... - 0 views

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    Big new break through in the steps to curing cancer. Harvard Scientist have found a new drug combination that stops the growth of cancer and could be the answer to curing all cancer. Although the research isn't the cure from cancer its the start that is needed to find cancer. In order for the two drugs to work they must be given together. The two drug combination could possible cure most types of cancer but for some it could spell disaster.
Nicholas Scholz

Parkinsons DIsease - NIH - 0 views

  • Parkinson's disease (PD) belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells
  • symptoms of PD are tremor, or trembling in hands
  • bradykinesia, or slowness of movemen
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  • As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks
  • difficulty in swallowing
  • At present, there is no cure for PD
  • and progressive
  • A therapy called deep brain stimulation (DBS) has now been approved by the U.S. Food and Drug Administration
  • Usually, patients are given levodopa
  • movements called dyskinesias that are a common side effect of levodopa
  • PD is both chronic
  • In some cases, surgery may be appropriate if the disease doesn't respond to drugs
  • No one can predict which symptoms will affect an individual patient, and the intensity of the symptoms also varies from person to person.
  • PD research in laboratories at the National Institutes of Health (NIH)
  • Scientists looking for the cause of PD
  • develop new protective drugs that can delay, prevent, or reverse the disease.
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    This article pertains to the neurological disorder, Parkinson's Disease (PD). PD is known to reduce motor system function due to the loss of dopamine-producing brain cells. Most symptoms related to PD include tremors, trembling, and slowness of movement (bradykinesia). As the disease progresses these tremors begin to effect daily activities like chewing and speaking. Unfortunately there is no cure for Parkinson's Disease. The most common treatment for PD is the use of medications such as levodopa. Due to complications with current medications other treatments like deep brain stimulation and surgery are commonly used. Parkinson's Disease is both chronic and progressive. Tremors and other symptoms will occur for long periods of time and possibly grow worse. Patients with PD experience varying symptoms and intensities. Current research being done in response to Parkinson's is being conducted at the National Institute of Health (NIH) and elsewhere. Current topics of research include discovering the cause of PD, and the development of protective drugs needed to delay, prevent, and even reverse the disease.
Nicholas Scholz

Alzheimer's - Alzheimer's Association - 0 views

  • Alzheimer's is a type of dementia that causes problems with memory, thinking and behavior.
  • Alzheimer's disease accounts for 50 to 80 percent of dementia cases.
  • Up to 5 percent of people with the disease have early onset Alzheimer's
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  • Those with Alzheimer's live an average of eight years after their symptoms become noticeable
  • However, serious memory loss, confusion and other major changes in the way our minds work may be a sign that brain cells are failing.
  • Each nerve cell connects with many others to form communication networks
  • Keeping everything running requires coordination as well as large amounts of fuel and oxygen
  • Plaques are deposits of a protein fragment called beta-amyloid (BAY-tuh AM-uh-loyd) that build up in the spaces between nerve cells.
  • Tangles are twisted fibers of another protein called tau (rhymes with “wow”) that build up inside cells.
  • It's the destruction and death of nerve cells that causes memory failure, personality changes, problems carrying out daily activities and other symptoms of Alzheimer'
  • Ninety percent of what we know about Alzheimer's has been discovered in the last 15 years
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    Alzheimer's is actually a common form of dementia. Roughly 50-80 percent of patients with dementia are associated with Alzheimer's. Alzheimer's is considered a neurological disorder with loss of memory, thinking and behavioral function. Alzheimer's is common diagnosed in patients 65 and older with the exception of patients with Early-Onset Alzheimer's. Alzheimer's progressively worsens over time and commonly culminates in death 8 years after symptoms start to arrive. Again no cure has been found for alzheimer's, but certain medications are used to treat symptoms. A build-up of plaques and tangles in the brain is suspected to kill nerve cells and cause a loss of brain function. The loss of nerve cells causes gaps in the communication network and eventually causes a loss of function in those areas of the brain. Although scientists do not know their exact role in Alzheimer's, patients have been associated with an abundant amount of these abnormal structures.
Nicholas Scholz

Epilepsy - NIH - 0 views

  • The epilepsies are a spectrum of brain disorders ranging from severe, life-threatening and disabling, to ones that are much more benign
  • seizures can be controlled with modern medicines and surgical techniques
  • Epilepsy may develop because of an abnormality in brain wiring, an imbalance of nerve signaling chemicals called neurotransmitters
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  • Only when a person has had two or more seizures is he or she considered to have epilepsy
  • For about 70 percent of those diagnosed with epilepsy,
  • normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and behavior
  • Issues may also arise as a result of the stigma attached to having epilepsy
  • the risk of seizures restricts their independence (some states refuse drivers licenses to people with epilepsy) and recreational activities.
  • Ongoing research is focused on developing new model systems that can be used to more quickly screen potential new treatments
  • Researchers funded by the National Institutes of Health have developed a flexible brain implant that could one day be used to treat seizures
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    Epilepsy is a neurological disorder associated with sudden seizures. In diagnosing epilepsy, the patient must have displayed two unexpected seizures. Epilepsy can be life - threatening and disabling or benign. Typical symptoms associated with epilepsy are strange sensations, emotions, and behavior. The cause of epilepsy is uncertain, but abnormal brain wiring may have an effect. With no cure for epilepsy, modern day medications and surgeries are used to treat patients. Due to the stigma associated with epilepsy, some children develop behavioral and emotional issues. The restriction of independence, like being denied a drivers license due to seizures, is also emotionally challenging for these patients. Current research being conducted for patients with epilepsy include the development of new models used to determine treatments, and brain implants which control seizures. 
Elizabeth Bundschuh

#Gene Silencing - 0 views

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    In cancer cells good genes are turned off, while bad ones are turned on through a process called DNA Methylation. The good genes could suppress the cancer if the methyl groups suppressing the genes were removed. Soy Isoflavones, antioxidants found in anything made of soy flour, have been shown to reverse Methylation. This allows the good genes to become activated. This can not only help prevent cancer, but help improve the efficiency of existing treatments, radiation and chemotherapy. The prevention of methylation may also help slow the progression and spreading of cancer. Soy Isoflavones have virtually no negative side affects making them another useful tool in finding better ways to fight and cure cancer.
Nicholas Scholz

Treatments and Medications Used for Patients with MS - 0 views

  • Corticosteroids are mainly used to reduce the inflammation that spikes during a relapse
  • Beta interferons. These types of drugs — such as Avonex, Betaseron, Extavia and Rebif — appear to slow the progress of multiple sclerosis, reduce the number of attacks and lessen the severity of attacks
  • (Copaxone). This medication may reduce the number of MS attacks
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  • (Tysabri). This medication may reduce the number of MS attacks by interfering with the movement of potentially damaging immune cells from your bloodstream to your brain and spinal cord.
  • Teriflunomide (Aubagio). This oral medication reduces attacks and lesions in people with MS.
  • Medications such as amantadine may help reduce fatigue due to multiple sclerosis.
  • Dalfampridine (Ampyra). This oral medication may improve walking speed in some people. The major side effect is seizures.
  • Muscle relaxants. If you have multiple sclerosis, you may experience painful or uncontrollable muscle stiffness or spasms, particularly in your legs. Muscle relaxants such as baclofen (Lioresal) and tizanidine (Zanaflex) may improve muscle spasticity
  • A physical or occupational therapist can teach you stretching and strengthening exercises and show you how to use devices that can make it easier to perform daily tasks.
  • For example, stem cell transplantation is being studied. In a stem cell transplant, doctors inject healthy stem cells into your body to replace diseased stem cells.
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    Though MS obviously has no cure there are plenty of procedures and medications that can be used to lessen the effects of the disease. Treating specific attacks reduces the damage to the myelin sheath. Two methods for controlling the attacks are plasma exchanges and corticosteroids. Another way to control the effects of MS is by slowing the progression of the disease. There are many different drugs that slow the rate of relapses some of which include Beta Interferons, Copaxone, Gilenya, and Tysabri. In addition to these medications, other strategies can be used to treat the symptoms, which include physical therapy and muscle relaxants. 
Elizabeth Bundschuh

Introduction to Cancer Immunotherapy - 0 views

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    There is no "magic bullet" in the fight against cancer, but one step towards curing cancer is Immunotherapy. The generally accepted hypothesis is that the immune system is the best tool humans have for fighting disease. Immunotherapy is thought to be less toxic than current treatments, however it is rarely used by itself to treat cancer. There are limitations to the effectiveness of Immunotherapy; the normal immune system cannot sense tumor cells, the response from the immune system is not strong enough when the body does recognize tumor cells, and tumors can defend themselves. There are three types of Immunotherapy Passive, components of the immune system are engineered outside of the body to attack cancer cells; Active, stimulates the body's own immune system to fight cancer; and Combination, uses both passive and active activity. Passive Immunotherapy's use antibodies created outside of the body to provide immunity or help fight off a disease. One type of passive immunotherapy is Monoclonal antibody therapy (mAb), the most widely used form of immunotherapy. Active Immunotherapy work by stimulating the immune system to 'actively' respond to the disease. One type of active immunotherapy is Provenge, a therapeutic prostate cancer vaccine. Therapeutic cancer vaccines are given to patients with cancer to help stimulate the immune system to fight the cancer. Combination Therapy is still in clinical studies but is thought to have a greater potential than active or passive immunotherapy because it combines the activity of both therapies. Immunotherapy may not be the magic bullet to fighting cancer, but when used early and with other treatments it has proven effective.
Nicholas Scholz

Predicting the Spread of Brain Tumors Using Modern Day Biotechnology - 0 views

  • ISOpure uses a set of tumor expression profiles and a panel of healthy tissue expression profiles to generate a purified cancer profile for each tumor sample, and an estimate of the proportion of RNA originating from cancerous cells
  • samples pre-selected to have a high cancerous cell content using pathological estimates [20-23], thereby introducing variability into expression profiles that cannot be removed by current computational pre-processing methods
  • he challenge of computational purification is to decompose each tumor profile tn (a vector of length G) into its component cancer profile (the vector cn), and normal profile
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  • Computational purification of tumor expression profiles by ISOpure improves the accuracy of subsequent prognostic models for lung and prostate cancer by reducing inter-sample variation in the amount and type of gene expression signal in the tumor profile that is due to normal tissue contamination.
  • Our analysis demonstrated approximately 10% improvement in prediction of EPE when using ISOpure cancer profiles compared with the unpurified profiles.
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    Using the ISOpure computational purification tool, scientists and medical professionals can develop a prognosis and treatment plan for a certain cancer patients at a much quicker rate. The tool used in this process can help identify the cancerous tissue located in the organs and provide medical professionals further notice of the proportion of RNA originating from cancer cells allowing them to develop treatment plans ahead of time. ISOpure uses an algorithm which determines the proportion of RNA in the organ(s). The real challenges of developing these treatments is of course extracting a portion of tissue with both a normal profile and a cancer profile to predict the spread of the disease. After this portion of tissue has been extracted the ISOpure modeling can process the data using simple MATLAB software. The success of this computational tool is noted to improve the prediction of extra-prostatic-extension (EPE) by 10% in cancer profiles compared to the unpurified models. 
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