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Home/ Authentic Science Research 2013-2014/ Contents contributed and discussions participated by Elizabeth Bundschuh

Contents contributed and discussions participated by Elizabeth Bundschuh

Elizabeth Bundschuh

Ethnobotany - 0 views

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    Article discusses the different uses of plants briefly and then provides ideas for Experiments. One possible Experiment is how bacteria reacts with different plant extracts. Then it could help determine whether homeopathic medicine works.
Elizabeth Bundschuh

Microorganisms - 0 views

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    Discusses different ways to research bacteria growth. Also provides solutions for potential problems. Talks about using chemicals to see what protects best against bacteria.
Elizabeth Bundschuh

Homeopathy: The effective alternative to Medicine - 0 views

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    Homeopathic medicine treats/alleviates symptoms instead of indiscriminately killing bacteria. Helps keep an internal balance of Bacteria. Details Multiple studies.
Elizabeth Bundschuh

Examples of Antibiotic Sensitivity Testing Methods - 0 views

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    There are several different ways to test antibiotic resistance. The category is Diffusion methods. About 1mil of a solution is used and bacteria growth is observed. The second is Disk diffusion method which uses an agar plate. The antibiotic is placed in a ring outside the bacteria and if the bacteria grows outside of the ring it is resistant to the antibiotic, if it doesn't the antibiotic works. There are other methods such as the E-Test, which involves a plastic strip and varying strengths of an antibiotic; Genotypic Methods, which allows testing for a specific mutation; and other more expensive methods of testing.
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    There are several different ways to test antibiotic resistance. The category is Diffusion methods. About 1mil of a solution is used and bacteria growth is observed. The second is Disk diffusion method which uses an agar plate. The antibiotic is placed in a ring outside the bacteria and if the bacteria grows outside of the ring it is resistant to the antibiotic, if it doesn't the antibiotic works. There are other methods such as the E-Test, which involves a plastic strip and varying strengths of an antibiotic; Genotypic Methods, which allows testing for a specific mutation; and other more expensive methods of testing.
Elizabeth Bundschuh

Mission Critical:Preventing Anitibiotic Resistant - 0 views

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    Antibiotic Resistance is a real problem plaguing healthcare. To prevent antibiotic from never working, steps need to be taken now. For example, patients should not save medicine for the next time they are sick. Another thing a person can do is not skip doses of medicine. There are also many things doctors and pharmacists can do. They can collaborate to better educate patients and be careful about how medicine is prescribed.
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    Antibiotic Resistance is a real problem plaguing healthcare. To prevent antibiotic from never working, steps need to be taken now. For example, patients should not save medicine for the next time they are sick. Another thing a person can do is not skip doses of medicine. There are also many things doctors and pharmacists can do. They can collaborate to better educate patients and be careful about how medicine is prescribed.
Elizabeth Bundschuh

Researchers identify genetic mutation for rare cancer | University of Michigan Comprehe... - 0 views

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    A woman with a solitary fibrous cancer, the cancer is only seen a couple hundred times a year, was enrolled MI-ONCOSEQ which led to the discovery of the mutation that causes this cancer. Researchers at University of Michigan ran the tumors genome and identified a mutations. The mutation was unusual, a fusion between two genes, NAB2 and STAT6. Normally mutation are identified because of the they are seen over and over again. However, in this woman's case, there were no known mutations, so scientists looked at what had changed. Then 51 other samples of solitary fibrous tumors were tested for the mutation; all of them tested positive for the mutation. The NAB2-STAT6 fusion may prove hard to treat with target therapy, but scientists may be able to disrupt its growth cycle which leads to this fusion. More research still needs to be done to determine ways in which the knowledge of this mutations can be applied, but for now it is a great start at tackling these rare tumors.
Elizabeth Bundschuh

#Gene Silencing - 0 views

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    In cancer cells good genes are turned off, while bad ones are turned on through a process called DNA Methylation. The good genes could suppress the cancer if the methyl groups suppressing the genes were removed. Soy Isoflavones, antioxidants found in anything made of soy flour, have been shown to reverse Methylation. This allows the good genes to become activated. This can not only help prevent cancer, but help improve the efficiency of existing treatments, radiation and chemotherapy. The prevention of methylation may also help slow the progression and spreading of cancer. Soy Isoflavones have virtually no negative side affects making them another useful tool in finding better ways to fight and cure cancer.
Elizabeth Bundschuh

Medical advances hold promise for less-destructive cancer treatment by way of genetic m... - 0 views

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    If a mutation occurs in a person's genes it can cause cancer. The future of cancer therapy is identifying and targeting these mutations. A trial at the University of Florida, known as NSCABP-FC-7 takes the genetic fingerprint of a patients DNA and gives them a personalized treatment based on the information. The idea is to move away from the traditional cytotoxic treatment, and towards less toxic personalized medicine. However, the toxicity of cancer drugs is decreasing due to technology's increasing ability to target and destroy specific cells, and not healthy cells. Washington University St. Louis as well as other institutions have become part of the study. Overall, the future of cancer treatment lies in targeted therapies and personalized medicine.
Elizabeth Bundschuh

Proton Therapy: The Cancer Treatment of the Future - 0 views

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    Proton therapy in a painless, noninvasive type of radiation to treat malignant tumors. It has been used successfully in against a variety of tumors and has fewer side affects then conventional photon therapy. Both Photon and Proton therapies work in the same ways by destroying cancer cells and preventing them from dividing. Proton therapy penetrates less healthy tissue than photon therapy. That means that proton therapy has fewer side effects and a faster recovery. Proton therapy needs time to grow. Costs for therapy rooms are falling, but many insurances do not cover proton therapy and many medical professionals need to be educated about and trained to use proton therapy. Overall proton therapy is a quickly becoming a more efficient, better way to treat cancer.
Elizabeth Bundschuh

Do we know what causes childhood leukemia? - 0 views

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    The cause of most cases of pediatric leukemia is not known, as most sufferers do not display any risk factors for the disease. However scientists have begun to understand how certain changes in DNA can cause leukemia. Cancer can be caused by mutation oncogenes, the genes that control when cells divide. A translocation between chromosomes 2 and 22 causes almost all cases of childhood chronic myeloid leukemia and childhood acute lymphocytic leukemia. Other genetic mutations can be inherited, however most of the mutations that cause leukemia develop after birth. Environmental factors, when combined with a genetic predisposition for leukemia, may trigger the disease. However the cause of most pediatric leukemia remains unknown.
Elizabeth Bundschuh

Washington University, St. Jude team to unravel genetic basis of childhood cancers | Ne... - 0 views

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    Washington University School of Medicine and St. Jude's Children's Research Hospital have teamed up to identify genetic mutations that cause pediatric cancer. There are over 600 patient's genes being analyzed. The tumor cells are compared to the patients healthy cells and the differences are recorded. The program is trying to identify a mutation that causes a healthy cell to turn into a cancerous one. This in turn can help scientists develop new treatments to help young cancer patients.
Elizabeth Bundschuh

Childhood Cancer's Health Woes Persist for Years - WSJ.com - 0 views

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    Pediatric patients are surviving their cancer and growing into adults. However, doctors are becoming increasingly concerned about the long-term health effects of the treatments that saved their patient's life. Many serious health conditions go undiagnosed because Doctors do not always think about the conditions that may effects pediatric cancer survivors. There was a study conducted with 1700 participants by St. Jude's Hospital. The participants were 10 years past their diagnosis and underwent lots of tests to determine any long-term conditions they might have. The average age of the study was 33. There are almost 400,000 pediatric cancer survivors and that number will grow. It is imperative to ensure follow up programs are in place and that doctors use minimal radiation.
Elizabeth Bundschuh

Introduction to Cancer Immunotherapy - 0 views

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    There is no "magic bullet" in the fight against cancer, but one step towards curing cancer is Immunotherapy. The generally accepted hypothesis is that the immune system is the best tool humans have for fighting disease. Immunotherapy is thought to be less toxic than current treatments, however it is rarely used by itself to treat cancer. There are limitations to the effectiveness of Immunotherapy; the normal immune system cannot sense tumor cells, the response from the immune system is not strong enough when the body does recognize tumor cells, and tumors can defend themselves. There are three types of Immunotherapy Passive, components of the immune system are engineered outside of the body to attack cancer cells; Active, stimulates the body's own immune system to fight cancer; and Combination, uses both passive and active activity. Passive Immunotherapy's use antibodies created outside of the body to provide immunity or help fight off a disease. One type of passive immunotherapy is Monoclonal antibody therapy (mAb), the most widely used form of immunotherapy. Active Immunotherapy work by stimulating the immune system to 'actively' respond to the disease. One type of active immunotherapy is Provenge, a therapeutic prostate cancer vaccine. Therapeutic cancer vaccines are given to patients with cancer to help stimulate the immune system to fight the cancer. Combination Therapy is still in clinical studies but is thought to have a greater potential than active or passive immunotherapy because it combines the activity of both therapies. Immunotherapy may not be the magic bullet to fighting cancer, but when used early and with other treatments it has proven effective.
Elizabeth Bundschuh

Types of Cancer Immunotherapy | What Is Immunotherapy - 0 views

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    Immunotherapy can be used to treat cancer by activating the body's immune system. One way to do this is by using Monoclonal Antibodies which stimulate a variety of immune responses that lead to tumor-cells death. Another type of immunotherapy is deactivating Checkpoint Inhibitors. These checkpoints help to make sure the immune system does not attack healthy cells; deactivating these checkpoints on cancer cells it allows the immune system to attack and has been effective in clinical trials. The third type of immunotherapy is Cytokines, which stimulates a broad immune response against a specific tumor antigen. The last type of immunotherapy is therapeutic cancer vaccines which stimulate the immune system to fight against a tumor's antigens. This is a durable response that tries to activate the immune system to fight the tumor cells. There are many ways immunotherapy can be used to help fight cancer.
Elizabeth Bundschuh

Profile Somatic Genotyping Study - Dana-Farber Cancer Institute - 0 views

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    Scientists at the Brigham and Women's Hospital as well as scientists at the Dana Farber Cancer Institute have been compiling and analyzing DNA from patients with tumors. The study using a program known as OncoMap, scanned for known mutations. In a new phase of the study, the program OncoPanel, is designed to recognize new mutations as well as previously known mutations. The goal of this study is to help locate these mutations which then could allow scientists to develop new forms of target therapy to combat cancer.
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