Bioengineering to generate healthy skin - 1 views
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That is, using a small biopsy from a specific patient, they can generate almost the entire cutaneous surface of that individual in the lab.
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that it is possible to isolate epidermic stem cells from patients with different genetic skin diseases, cultivate them and, using molecular engineering as a first step, incorporate the therapeutic genes into each patient's genome to take the place of the one that the patient does not have or that functions abnormally. Afterwards, in the second step, the stem cells would be assembled into patches ready to be transplanted onto the patients.
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"What we did in this case -- explains Marcela del Río -- was to transfer a normal SPINK-5 gene to a patient's stem cells and later use these cells to generate skin that could be transplanted to experimental models, such as mice."