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Galactic Cosmic Radiation consisting of high-energy, high-charged (HZE) particles poses a significant threat to future astronauts in deep space. Aside from cancer, concerns have been raised about late degenerative risks, including effects on the brain. In this study we examined the effects of 56Fe particle irradiation in an APP/PS1 mouse model of Alzheimer's disease (AD). We demonstrated 6 months after exposure to 10 and 100 cGy 56Fe radiation at 1 GeV/µ, that APP/PS1 mice show decreased cognitive abilities measured by contextual fear conditioning and novel object recognition tests. Furthermore, in male mice we saw acceleration of Aβ plaque pathology using Congo red and 6E10 staining, which was further confirmed by ELISA measures of Aβ isoforms. Increases were not due to higher levels of amyloid precursor protein (APP) or increased cleavage as measured by levels of the β C-terminal fragment of APP. Additionally, we saw no change in microglial activation levels judging by CD68 and Iba-1 immunoreactivities in and around Aβ plaques or insulin degrading enzyme, which has been shown to degrade Aβ. However, immunohistochemical analysis of ICAM-1 showed evidence of endothelial activation after 100 cGy irradiation in male mice, suggesting possible alterations in Aβ trafficking through the blood brain barrier as a possible cause of plaque increase. Overall, our results show for the first time that HZE particle radiation can increase Aβ plaque pathology in an APP/PS1 mouse model of AD.

Demo of a Linux Desktop controlled by a PS3 move controller.

A long read but very interesting and well written.

PS: Does this quote from the article not sound a lot like Inception? 'In any given situation, the brain will retrieve old memories to inform an organism's behavior. If the memory is relevant to the situation, the organism can act on the information; if it is not relevant, then the organism can learn from the situation and create a new memory. With reconsolidation, researchers argued, there seemed to be a brief window in between the retrieval of an old memory and the creation of a new memory in which the old memory is vulnerable to manipulation.'

Soon caesium in your watch !

very nice indeed ... how much more accurate are our galileo clocks?

This small clock is around 10^-12 @1d in stability (loose 1 second after 300000 years) and 50 ns in accuracy. For comparison Galileo and GPS clocks are around 10^-14 @1d in stability and 1 ns in accuracy. And ACES/PHARAO will be around 3*10^-16 @1d in stability and 0.3 ps accuracy.

who wants 100 cores ... future of PAGMO?

The problem with this flurry of activity today regarding multicore architectures is that it is really unclear which one will be the winner in the long run. Never understimate the power of inertia, especially in the software industry (after all, people are still programming in COBOL and Fortran today). For instance, NVIDIA gives you the Teslas with 10000 cores, but then you have to rewrite extensive parts of your code in order to take advantage of this. Is this an investment worth undertaking? Difficult to say, it would certainly be if the whole software world moves into that direction (which is not happening - yet?). But then you have other approaches coming out, suche as the Cell processor by IBM (the one on the PS3) which has really impressive floating point performance and, of course, a completely different programming model. The nice thing about this Tilera processor seems to be that it is a general-purpose processor, which may not require extensive re-engineering of existing code (but I'm really hypothesizing, since the thechincal details are not very abundant on their website).

Moreover PaGMO computation model is more towards systems with distributed memory, and not with shared memory (i.e. multi-core). In the latter, at certain point the memory access becomes the bottleneck.

A report on a blind schizophreniac person who regained vision in some of her personalities and in others not.

Quantum internet will enable perfectly secure communications, but the technology and means to build the required quantum memories and routers are still many years distant. The proposal here is to store qubits and send them in containers over the oceans. Researchers claim that it is possible to send information at bandwidths measured in teraahertz outperforming the predictions of a quantum router internet. It can be thought in space systems as well. Then the problem is still for how long are we able to store a qubit, without dephasing... PS: As a curiosity, you can find a very interesting book about containers and how in some way they changed our world: Mark Levinson's book 'The Box' http://press.princeton.edu/titles/9383.html Maybe they will do it again