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Strains of the quadriceps muscle usually occur during sprinting, jumping or kicking. Strains are seen in all the quadriceps muscles but are most common in the rectus femoris, which is more vulnerable to strain as it passes over two joints: the hip and the knee.

Thigh contusions, resulting from a direct blow, can be a very disabling injury. Contusions of the anterior portion of the thigh muscle are usually more serious than those involving the lateral portion of the quadriceps muscle, because of the differences in muscle mass percent in the two areas.