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When Pantelis Georgiou and his fellow biomedical engineers at Imperial College London decided to design an intelligent insulin pump for diabetes patients, they started at the source. "We asked ourselves, what does a pancreas do to control blood glucose?" Georgiou recalls. The answer is pretty well known: The organ relies primarily on two populations of cells—beta cells, to secrete insulin when blood glucose is high, and alpha cells, which release a hormone called glucagon when glucose levels are low. "We simulated them both in microchip form," Georgiou says. This biomimetic approach diverges from today's dominant method of delivering only insulin using a relatively simple control system.

Theodore Berger and his team at the USC Viterbi School of Engineering’s Department of Biomedical Engineering have developed a neural prosthesis for rats that is able to restore their ability to form long-term memories after they had been pharmacologically blocked.In a dramatic demonstration, Berger blocked the ability to rats to form long-term memories by using pharmacological agents to disrupt the neural circuitry that communicates between two subregions of the hippocampus, CA1 and CA3, which interact to create long-term memory, prior research has shown.

For the price of a sports car, you can have a pint of your blood drawn and a month later receive your entire genome—all 6 billion base pairs—encoded in a 1.5-gigabyte data file. That means the price has dropped to 1/50 000 of what it was less than a decade ago (the first genome, after all, cost US $3 billion). Yet the price is expected to fall to 1/1000 of the current price in the next four years. The cultural ramifications of a $100 genome—which is where we’re headed, whether it takes 4 years or 10—are as wide and deep as those of any other recent innovation, including search engines and cellphones.

The race to create tiny wireless sensors that could monitor anything from pressure in the eyes and brain to the stability of bridges appears to be heating up. Earlier this month, IEEE Spectrum reported on two approaches to creating an almost-indefinitely-running sensor using piezoelectric systems to convert tiny vibrations into power. Now, another team from the University of Michigan has created an alternative approach that uses solar power to keep the sensor running autonomously for many years.

Experimental microbial fuel cells could turn bacteria into batteries that generate electricity from biomass. The key to this technology is the ability of bacteria to transfer electrons to their surroundings—for example, to the anode of a microbial fuel cell. But if the organisms have to be in direct contact with the anode, such devices would have to have extremely large surface areas. Researchers from Aarhus University, in Denmark, report today in the journal Nature that bacteria appear to conduct electricity while separated by several millimeters, at least a thousand times as far apart than previously demonstrated. The naturally occurring electric currents, if confirmed, would allow bacteria spaced at least 12 millimeters apart to communicate electrically. The discovery might lead to new paths to treating infection and a better understanding of microbial ecosystems.