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"An industrial assembly line includes a factory, workers, and a conveyor system," said NYU Chemistry Professor Nadrian Seeman, the study's senior author. "We have emulated each of those features using DNA components." The assembly line relies on three DNA-based components. The first is DNA origami, a composition that uses a few hundred short DNA strands to direct a very long DNA strand to form structures to any desired shape. These shapes are approximately 100 x 100 nanometers in area, and about 2 nm thick (a nanometer is one billionth of a meter). DNA origami serves as the assembly line's framework and also houses its track. The second are three DNA machines, or cassettes, that serve as programmable cargo-donating devices. The cargo species the researchers used are gold nanoparticles, which measure 5 to 10 nanometers in diameter. Changing the cassette's control sequences allows the researchers to enable or prevent the donation of the cargoes to the growing construct. The third is a DNA "walker," which is analogous to the chassis of a car being assembled. It moves along the assembly line's track, stopping at the DNA machines to collect and carry the DNA "cargo." As the walker moves along the pathway prescribed by the origami tile track, it encounters sequentially the three DNA devices. These devices can be switched between an "on" state, allowing its cargo to be transferred to the walker, and an "off" state, in which no transfer occurs. In this way, the DNA product at the end of the assembly line may include cargo picked up from one, two, or three of the DNA machines. "A key feature of the assembly line is the programmability of the cargo-donating DNA machines, which allows the generation of eight different products," explained Seeman.

King Tut, depicted here by a gold funerary mask, was a frail pharaoh, according to a new DNA study. Tutankhamun was beset by malaria and a bone disorder—and possibly compromised by his newly discovered incestuous origins, researchers say. (Read the full story: "King Tut Was Disabled, Malarial, and Inbred, DNA Shows.")Released Tuesday by the Journal of the American Medical Association, the report is the first DNA study ever conducted with ancient Egyptian royal mummies. It apparently solves several mysteries surrounding the 14th-century B.C. pharaoh, including how he died and who his parents were."He was not a very strong pharaoh. He was not riding the chariots," said study team member Carsten Pusch, a geneticist at Germany's University of Tübingen. "Picture instead a frail, weak boy who had a bit of a club foot and who needed a cane to walk."

Andrew Phillips holds the title of Scientist with Microsoft Research Cambridge, and he's working on a method of programming that compiles into DNA. Part of this involves a visual programming language called Stochastic Pi Machine, or SPiM. This system models biological processes to help give researchers feedback on how organisms will react to modifications. The hope is that this can be used to help scientists program for large biological systems using modular components compiled to DNA. Yes, I’m in way over my head here, but I do my best to ask Andrew about the role this will play in medical treatment going forward, what it means to DNA computing, and the ability of back-engineering the genetic code we don’t use now.

Scientists from Columbia University, Arizona State University, the University of Michigan, and the California Institute of Technology (Caltech) have created a robot that’s just 4 nanometers wide. And no, it doesn’t have flashing lights, video cameras or wheels. It does, however, have four legs, and the ability to start, move, turn, and stop. Descendants of the molecular nanobot, or “spider,” could someday be used to treat diseases such as cancer or diabetes. The team built the spider by starting with a protein called streptavidin, that conveniently has four symmetrically-placed binding pockets for a chemical called biotin. The legs were made from four strands of biotin-labeled DNA, which were bound to the pockets. Three of the legs were made from enzymatic DNA, which is a type that binds to and then dissociates (cuts away) from other particular sequences of DNA. Its fourth leg was made from what the researchers call a “start strand” of DNA - it keeps the spider tethered to its starting site, until it’s released.

Andrew Phillips holds the title of Scientist with Microsoft Research Cambridge, and he's working on a method of programming that compiles into DNA. Part of this involves a visual programming language called Stochastic Pi Machine, or SPiM. This system models biological processes to help give researchers feedback on how organisms will react to modifications. The hope is that this can be used to help scientists program for large biological systems using modular components compiled to DNA. Yes, I’m in way over my head here, but I do my best to ask Andrew about the role this will play in medical treatment going forward, what it means to DNA computing, and the ability of back-engineering the genetic code we don’t use now

) Die gezielte Manipulation von Strukturen im Nanometerbereich ist eine Grundlage der modernen Biotechnologie. Zu den vielseitigsten Bausteinen im Bereich von Millionstel Millimetern gehört die DNA, der Träger der Erbinformation. Im Organismus kommt das Molekül in linearen und zirkulären Formen vor, aus denen dann technologisch höhere Strukturen erzeugt werden können. Deren spezifische Form ist die Folge eines Wechselspiels mehrerer physikalischer Kräfte. LMU-Forscher um den Biophysiker Professor Erwin Frey konnten in Zusammenarbeit mit Schweizer Wissenschaftlern nun klären, welches Gewicht diese Kräfte jeweils haben und welche effektive Form der Bausteine daraus resultiert ("Excluded Volume Effects on Semiflexible Ring Polymers").

Die gezielte Manipulation von Strukturen im Nanometerbereich ist eine Grundlage der modernen Biotechnologie. Zu den vielseitigsten Bausteinen im Bereich von Millionstel Millimetern gehört die DNA, der Träger der Erbinformation. Im Organismus kommt das Molekül in linearen und zirkulären Formen vor, aus denen dann technologisch höhere Strukturen erzeugt werden können. Deren spezifische Form ist die Folge eines Wechselspiels mehrerer physikalischer Kräfte. LMU-Forscher um den Biophysiker Professor Erwin Frey konnten in Zusammenarbeit mit Schweizer Wissenschaftlern nun klären, welches Gewicht diese Kräfte jeweils haben und welche effektive Form der Bausteine daraus resultiert ("Excluded Volume Effects on Semiflexible Ring Polymers").

Single-walled carbon nanotube (SWCNT)-based thin film transistors (TFTs) could be at the core of next-generation flexible electronics – displays, electronic circuits, sensors, memory chips, and other applications that are transitioning from rigid substrates, such as silicon and glass, to flexible substrates. What's holding back commercial applications is that industrial-type manufacturing of large scale SWCNT-based nanoelectronic devices isn't practical yet because controlling the morphology of single-walled carbon nanotubes is still causing headaches for materials engineers.