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Bringing a new drug to market typically costs around $2.6 billion and involves 10-12 years of clinical trials and regulatory review, which consumes more than half of the standard 20-year patent term. To help innovators recover this investment, the United States offers Patent Term Extensions (PTEs) under the Hatch-Waxman Act of 1984 and the Generic Animal Drug and Patent Term Restoration Act of 1988. A qualifying patent covering human drugs, medical devices, animal drugs, veterinary biologics, or food and color additives may receive up to five extra years of exclusivity plus a six-month pediatric extension. Eligibility requires that the patent remain in force, has not been previously extended, and corresponds to the first approved marketing of the product. The extension period is calculated by subtracting pre-grant regulatory review time and any applicant inactivity from the total regulatory review duration. In Europe, Supplementary Protection Certificates (SPCs) introduced in 1993 serve a similar purpose. SPCs can extend protection for approved active ingredients or combinations by up to five years, with a mandatory six-month pediatric supplement. These certificates are obtained through national patent offices or the European Patent Office and apply only to the specific ingredient or combination listed in the marketing authorization. Globally, most developed markets including Japan, South Korea, Australia, and Israel impose a five-year cap on patent term extensions. Canada and India currently lack a comparable system. Successful lifecycle management requires integrating regulatory timelines into patent strategies, tracking approval dates in each jurisdiction, and filing extension applications promptly. By securing these additional years of exclusivity, pharmaceutical companies can delay generic competition and maintain vital revenue streams to fund future research and development. For a detailed, step-by-step guide to PTE and SPC requirements, calculation meth

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WWW.OFFICE.COM/SETUP BLOGS: WHICH VERSION OF MICROSOFT OFFICE IS BEST FOR ME? www.office.com/setup Blogs: Office 365 and Office 2016 share a lot of similarities, yet deciding between the two involves a lot of factors. Office 365 is a subscription-based service that currently uses Office 2016 apps, but when the next version of Office is released, users will get that as part of their subscription. Office 2016 is a buy-once app suite that brings you the Office 2016 apps as they are, without any available updates in the future. If you want to upgrade to the latest version of Office without paying for a subscription, you'll have to pay full price for the new version - there's no discounted upgrade option. These are only a couple differences between the two products. Looking to invest in Office? We break down the differences between the two products to help you decide which is better for personal and home use. See at Microsoft Store Quick-reference table Apps and pricing Multiple devices Connectivity Support Storage Conclusion QUICK-REFERENCE TABLE Category Office 365 Home Office 365 Personal Office Home & Student 2016 Office Home & Business 2016 Office Professional 2016 Price $99.99 /year $9.99 /month $69.99 /year $6.99 /month $149.99 $229.99 $399.99 Users Up to 5 1 1 1 1 Apps Word Excel PowerPoint OneNote Outlook Publisher Access Word Excel PowerPoint OneNote Outlook Publisher Access Word Excel PowerPoint OneNote Word Excel PowerPoint OneNote Outlook Word Excel PowerPoint OneNote Outlook Publisher Access Devices 5 PCs or Macs 5 tablets 5 phones 1 PC or Mac 1 tablet 1 phone 1 PC 1 PC 1 PC Skype minutes 60 per month for each user 60 None None None OneDrive storage 1TB each for five users 1TB None None None APPS AND PRICING Office apps on the go. - www.office.com/setup Office 365 is a subscription-based service. If you choose to pay on a yearly basis, you essentially get a discount that works out to two free months per year. If you choose to pay on a monthly b

www.office.com/setup Blogs: Office 2016 for Mac is here, so we bring you everything you need to know about the new version of Office for Mac 2016, including Office 365, UK pricing, new features and more. OFFICE FOR MAC 2016 FIRST LAUNCHED AS PART OF OFFICE 365 IN JULY OF 2015, BUT MAC USERS WANTING TO BUY A COPY OUTRIGHT, RATHER THAN SUBSCRIBE, HAD TO WAIT FOR MICROSOFT TO LAUNCH THE BOXED VERSION. THAT FINALLY HAPPENED IN SEPTEMBER 2015, WHEN THOSE MAC USERS GOT THEIR WISH AND OFFICE 2016 FOR MAC BECAME AVAILABLE FOR £119.99 UPFRONT. HERE, WE TALK YOU THROUGH THE FEATURES IN OFFICE FOR MAC 2016, AND HELP YOU DECIDE WHETHER TO SUBSCRIBE TO OFFICE 365 OR BUY A COPY OUTRIGHT. PLUS, WE SHARE OFFICE FOR MAC 2016 UK PRICING FOR EACH VERSION. A number of new features for the MacBook Pro Touch Bar have been added as of February 2017, these are discussed here. Don't expect Microsoft Office for Mac 2017 anytime soon (or at all, for that matter). There was a five year gap between this current version of Office for Mac and its predecessor, Microsoft Office for Mac 2011. However, those with an Office 365 account will get regular, automatic updates since it is an online subscription. If you buy Office outright as a one-time software download, you won't get these benefits, so something to bear in mind. MICROSOFT OFFICE FOR MAC 2016 UK PRICE: HOW MUCH DOES OFFICE FOR MAC 2016 COST? Office Home & Student 2016 for Mac costs £119.99 ($149.99) and includes Word, Excel, PowerPoint and OneNote. It's available to buy from Microsoft UK here or Microsoft US here. Office Home & Business 2016 for Mac costs £229.99 ($229.99) and includes Outlook as well as Word, Excel, PowerPoint and OneNote. It's available to buy from Microsoft UK here or Microsoft US here. These versions are only available for one Mac. To install on more than one Mac Microsoft appears to be pushing users towards the 365 subscription model. If you buy a copy outright, you will only be able to install the copy on

Korean cola prices rose 9% year-on-year, while processed foods rose by nearly 70%. Data from the Consumer Affairs Institute of Korea's Comprehensive Information Website released on June 11 showed that processed foods such as Korean cola and instant rice were up 9% year-on-year in May.

www.office.com/setup Blogs: Evernote and OneNote are two of our favorite tools, but both have changed substantially since we last compared these two apps-in some ways, not for the best. Here's where these two stand today. www.office.com/setup LIFEHACKER FACEOFF: ONENOTE VS. EVERNOTE Now that Microsoft OneNote is free for Mac and Windows, the price and cross-platform barriers to…Read more WHAT'S NEW IN EVERNOTE In the last year, Evernote introduced a new pricing plan, redesigned its webapp, and added new features for its Android and iOS apps. THE FREE PLAN LOSES A FEATURE, BUT NOW THERE'S A MORE AFFORDABLE PAID PLAN Let's talk price first with Evernote, since it's the biggest change in the last year. The free plan no longer lets you email notes to Evernote, something most users enjoyed and used often prior to that change. Although you can get around this limitation with an IFTTT recipe, you won't get the full flexibility of Evernote's email-to-notes feature, such as specifying your destination notebook in the email subject line. So that's a bummer. On the positive side, however, Evernote introduced a new, more affordable paid plan called Evernote Plus. For $25 a year, you get offline notebooks for Evernote's mobile apps and the ability to lock the app on your phone with a PIN. Both of these used to require Evernote's Premium plan, which used to cost $45 a year. Finally, Evernote's Premium plan now costs $50 a year. But in return for those five extra bucks, you get larger upload limits: 10GB a month, instead of the previous 4GB data cap. With Evernote Premium, you can search attachments, scan business cards, view previous note versions, annotate PDFs, and use the new note presentation mode. EVERNOTE'S USER INTERFACE KEEPS EVOLVING www.office.com/setup Last year, Evernote took its redesigned, minimalist web client out of beta. Though slicker and easier on the eyes, the makeover also made the webapp less functional. You can't order

www.office.com/setup Blogs: Office 365 is a subscription based package that buys you time limited access to a number of Microsoft services and software packages, including the latest desktop Office suite, an online version of Office, cloud storage, and premium mobile apps.Stop Bashing Microsoft: 5 Ways In Which They're Awesome Stop Bashing Microsoft: 5 Ways In Which They're AwesomeMicrosoft doesn't always get fair treatment. When it comes down to it, they're a pretty awesome company. There's been enough Microsoft bashing, now it's time for some love.READ MORE Office 365 follows a business model known as Software as a Service (SaaS), which has commonly been used for deploying enterprise software. With subscription-based services like Spotify, Napster, or Amazon Prime, it has found its way into the consumer software market some time ago. Does Office 365 provide enough value to be worth the money? CAN YOU STILL USE IT ON YOUR DESKTOP? Yes, absolutely! Microsoft isn't moving Office entirely into the cloud just yet. While you can access Office Online via the browser and store your documents on OneDrive, Office 365 offers many other ways to access and edit your documents. The current package of Office 365 includes the Office 2013 desktop suite (Office 2011 for Mac users). In the summer or fall of this year, you will be able to upgrade to Office 2016.Don't Pay For Word! 5 Reasons You Should Use Office Online Don't Pay For Word! 5 Reasons You Should Use Office OnlineOffice Online is the free and cloud-connected version of Microsoft Office. Limitations are compensated by features, useful even to users of desktop Office. Best of all is itsREAD MORE Microsoft Office - www.office.com/setup WHAT IS INCLUDED & WHAT IS THE PRICE TAG? The exact composition of the package depends on the Office flavor you choose. Office 365 Home, Office 365 Personal, and Office 365 University include the following software: Word Excel PowerPoint OneNote (now free for everyone) Outlook Publ

Electric car maker Tesla has suffered continuous losses for nearly 15 years since its inception, has not yet achieved profit for a year, but its CEO Musk stated that in order to achieve them The clean energy target must be profitable. Tesla was established in July 2003 This year was 15th anniversary

2016 has ended and for you as a training manager this means end-of-the-year reports and planning for the New Year. You will be looking at the training initiatives and their success in the past year and planning for this year. To develop an effective training development strategy, you need to be aware of the trends in learning and development for this year. In case you use e-learning for your training, you definitely need to know the trends to watch out for. This blog will talk about 6 trends specific to e-learning that will dominate 2017.

The U.S. Environmental Protection Agency expects to save $12 million over four years. The City of Chicago anticipates saving $1.3 million over the same length of time. And the State of Minnesota expects to save at least $800,000. Governments of all sizes are finding ways to reduce IT costs while improving efficiency. What's their secret weapon? With public sector budgets shrinking in many places around the globe, smart governments are making taxpayer dollars stretch further by migrating from an on-premise environment to Microsoft Office 365 in the cloud. By moving to Office 365, governments can reduce both their capital and operating costs. And by saving money, they can make taxpayer dollars go further during a time when budgets are tight and there's often less revenue to work with. So how exactly can Office 365 save governments money? First, governments can cut back on the capital cost of investing in more computer servers. Second, they can reduce the administrative cost of having to maintain an IT environment. Third, they can lower their energy costs by reducing the size of their data centers. And they can also reduce costs using the many tools within Office 365 that improve employee efficiency. According to a study conducted by Forrester Consulting, Office 365 delivers an ROI of 321 percent with a payback period of two months for a composite midsize organization. That translates into huge value for public sector organizations! Among the government agencies that anticipating money saved by implementing Office 365 is the Environmental Protection Agency. The agency expects to save $12 million over four years by moving to the cloud and Office 365. Some of those savings will be in energy costs as the agency relies on Microsoft to operate its data centers. "The EPA will continue to lead the pack on environmental stewardship, and moving an IT environment to the cloud is a natural part of that," says Greg Myers, vice president of Microsoft Federal. "There

an Argentine woman has recovered from her incarceration 20 years later. It is bizarre that the perpetrator was her family and she was kidnapped in bed for a long time in order to punish her for making a boyfriend.

The Nokia E71 has once again gained another award! After the Mobile Choice UK touted E71 as the "Phone of the Year" and "Best Smartphone of the Year", this time WIRED magazine have awarded the "smart simplicity" phone as the "Test Best Cell Phone".

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Back by popular demand this year is Group's eConnect Conference.  This one one of my favorite events to be a part of this last year and so excited to participate again this year!  If for no other reason to attend this conference is the opportunity to visit Group's headquarter's in Loveland, Colorado.  The setting is beautiful and the facility is incredibly inspiring.  

SHARE Hotel Chocolat has released its first half-year (H1) results for financial year 2018/19, recording revenue of £80.7m, a 13% increase compared with £71.7m for the previous year.

www.office.com/setup Blogs: Today marks the general availability of Office 2016 for Windows, a suite of desktop applications that together with new mobile and web apps pushes Microsoft's new vision for PC-based productivity. Office 2016 is available immediately to Office 365 subscribers, as well as to individuals who would prefer to buy the software in standalone form. "We see Office 2016 as being just as important as the first release of Office," Microsoft group program manager Shawn Villaron told me in a briefing last week. "In the early days, Office was about bringing really important tools together to empower the individual for personal productivity. That was the way people wanted to work at that time. And for 20 to 30 years, Office fit right in. Today, things are changing. More people collaborate on work as groups and teams, so Office 2016 represents the change from personal productivity to team productivity." And that, really, is Office 2016 in a nutshell. If you're a typical information worker, student, or other person in need of standard productivity tools, Office 2016 of course works fine and represents an obvious and stable evolution from the Office version you're currently using. But the real meat in this release-now and going forward, as Office will of course be updated regularly, like Windows 10-is the designed around this new way of working. Confusing matters somewhat, Office-not Office 2016, but Office generally-is all over the place now. In addition to the classic, full-featured desktop suites on both Windows and Mac, Microsoft has high-quality Office Online web apps, mobile apps for Android, iOS, and Windows/Windows phones-and Office 365-specific solutions that are often available as web apps but are sometimes just integrated into the desktop applications. This ain't your father's Office anymore. Office everywhere: Microsoft Office is available on virtually any device you care to use. - www.office.com/setup Office eve

This tutorial on using conditional formatting to highlight dates is brought to us by MVP Frédéric Le Guen, with special acknowledgment and thanks to Ken Puls for assistance with translation from French to English. Date functions in Excel make it is possible to perform date calculations, like addition or subtraction, resulting in automated or semi-automated worksheets. The NOW function, which calculates values based on the current date and time, is a great example of this. Taking this functionality a step further, when you mix date functions with conditional formatting, you can create spreadsheets that display date alerts automatically when a deadline is near or differentiates between types of days, like weekends and weekdays. THE BASICS OF CONDITIONAL FORMATTING FOR DATES To find conditional formatting for dates, go to Home > Conditional Formatting > Highlight Cell Rules > A Date Occuring. www.office.com/setup You can select the following date options, ranging from yesterday to next month: www.office.com/setup These 10 date options generate rules based on the current date. If you need to create rules for other dates (e.g., greater than a month from the current date), you can create your own new rule. Below are step-by-step instructions for a few of my favorite conditional formats for dates. HIGHLIGHTING WEEKENDS When you design an automated calendar you don't need to color the weekends yourself. With the conditional formatting tool, you can automatically change the colors of weekends by basing the format on the WEEKDAY function. Assume that you have the date table-a calendar without conditional formatting: www.office.com/setup To change the color of the weekends, open the menu Conditional Formatting > New Rule www.office.com/setup In the next dialog box, select the menu Use a formula to determine which cell to format. www.office.com/setup In the text box Format values where this formula is true, enter the following WEEKDAY formula to determ

www.office.com/setup Blogs: The shrouded veil of secrecy has been lifted from the latest edition of Microsoft Office. Excitement for Office 2016 is still lagging behind the Windows 10 enthusiasm camp, but following the July 29 release of Windows 10, attention will return to the world's most popular productivity suite.When Does Windows 10 Come Out, How Can You Get It & What Happens to the Technical Preview? When Does Windows 10 Come Out, How Can You Get It & What Happens to the Technical Preview?Windows 10 is coming soon. Still confused about how the upgrade will work and wondering about the timeline? We have some answers, although more questions remain.READ MORE Office 2016, like Windows 10, has been re-designed within a revised Microsoft ethos. Office 2016 has been built from the ground-up with mobile and cloud users in mind, slotting in with the ever expanding fleet of Microsoft productivity applications. Office is, in general, a different set of tools from days gone by. We aren't confined to the five-or-so core products, and we can expand the functionality of the Office ecosystem using a massive range of add-ins and templates. Office 2016 logo - www.office.com/setup I'm using VirtualBox to preview Office 2016. Microsoft strongly suggested uninstalling Office 2013, which isn't currently viable due to work commitments. Using a virtual machine, however is a great way to explore different Office products alongside each other, without having to uninstall your current suite. I've also had a look at Office 2016 on Windows 10 Build 10130. Verdict: good times.How To Use VirtualBox: User's Guide How To Use VirtualBox: User's GuideLearn to use VirtualBox. Get virtual computers up and running inside your computer, without having to buy any new hardware.READ MORE Anyway, enough of that. Let's look at Office 2016. NEW OVERVIEW Much akin to the extended and inclusive testing phase of Windows 10, the Office 2016 preview has now accumulated over 1 million users,

Revenue for the fourth quarter of 2011 was $74.3 million, compared with $57.4 million for the fourth quarter of fiscal www.avg.com/activation 2010, an increase www.avg.com/activate of 29 percent. For the fiscal year 2011, revenue Install Avg With License Number activation was $272.4 million, avg.com/retail compared to $217.2 million reported in fiscal year 2010, an increase of 25 percent avg.com/activation.

A brilliant young scholar and gifted entrepreneur - Azeem Ibrahim was honoured as Alumnus of the Year in recognition of his exceptional career. His achievements have attracted considerable recognition around the globe and over the last few years Azeem has met and advised a number of world leaders on a wide variety of issues.