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Supercritical fluid chromatography (SFC) is an analytical technique that utilizes supercritical fluids as a mobile phase for sample separation.

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The analytical supercritical fluid chromatograph uses supercritical fluid (such as CO2) with good dissolution and mass transfer characteristics as the mobile phase, and optimizes the analysis and preparation conditions by adjusting the flow rate and composition of the mobile phase, as well as the system temperature and pressure.