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After completing molecule's basic benchwork and characterization, it is time to leverage powerful simulation software for in vitro-in vivo extrapolation. Integrating in silico advancements into program will help consumer expedite timeline for CMC (chemistry, manufacturing, and controls) and dosing strategies. We can identify absorption risks in the early development and optimize preclinical and clinical dosing strategies.

How can physiologically-based pharmacokinetic (PBPK) modeling maximize ADME performance and identify a path forward for GLP Tox and FIH formulations? GastroPlus incorporates in-vivo and in-vitro data to build animal models. The animal models can be scaled to human models, providing advanced insights on ADME performance in animals and humans. Case studies on insights that drive more efficient development…