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Casey Finnerty

Flu Deaths Reach Epidemic Level, but May Be at Peak - NYTimes.com - 0 views

  • Although the report supported getting flu shots, it said that new vaccines offering lifelong protection against all flu strains, instead of annual partial protection against a mix-and-match set, must be created.
  • “Vaccine effectiveness” is a very different metric from vaccine-virus match, which is done in a lab. Vaccine efficacy is measured by interviewing hundreds of sick or recovering patients who had positive flu tests and asking whether and when they had received shots.
  • During the 2009 swine flu pandemic, many elderly Americans had natural protection, presumably from flus they caught in the 1930s or ’40s.
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  • “Think about that,” Dr. Osterholm said. “Even though they were old, they were still protected. We’ve got to figure out how to capture that kind of immunity — which current vaccines do not.”
  • Dr. Bresee acknowledged the difficulties, saying: “If I had the perfect answer as to how to make a better flu vaccine, I’d probably get a Nobel Prize.”
  • a preliminary study rated this year’s vaccine as 62 percent effective, even though it is a good match for the most worrisome virus circulating.
  • urged Americans to keep getting flu shots.
  • Even though deaths stepped — barely — into epidemic territory for the first time last Saturday, the C.D.C. officials expressed no alarm, and said it was possible that new flu infections were peaking in some parts of the country.
  • Epidemiologists count how many death certificates are filed in a flu year, compare the number with normal years, and estimate what percentage were probably flu-related.
  • The C.D.C.’s vaccine effectiveness study bore out the point of view of a report released last year by the University of Minnesota’s Center for Infectious Disease Research and Policy. It said that the shot’s effectiveness had been “overpromoted and overhyped,” said Michael T. Osterholm, the center’s director.
  • At the same time, he praised the C.D.C. for measuring vaccine effectiveness in midseason. “We’re the only ones in the world who have data like that,” he said.
  • “To get a vaccine across the ‘Valley of Death’ is likely to cost $1 billion,”
  • the metric means the shot “reduces by 62 percent your chance of getting a flu so bad that you have to go to a doctor or hospital.”
  • “far from perfect, but by far the best tool we have to prevent influenza.”
  • Most vaccinations given in childhood for threats like measles and diphtheria are 90 percent effective or better. But flu viruses mutate so fast that they must be remade annually.
Casey Finnerty

Flu shot time? Google Flu Trends predicts worst season on record. - Slate Magazine - 0 views

  • If you ask the Centers for Disease Control and Prevention in Atlanta, this year’s flu season is looking “moderately severe.”
  • if you ask Google Flu Trends, we’re in the midst of an outbreak that is shaping up to be the most extensive on record.
  • CDC still drives the bulk of national media coverage
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  • The CDC’s current estimates aren’t all that current.
  • the numbers can tell us only how many people were suffering from the flu a couple weeks ago.
  • scans millions of Google searches from around the world to track flu activity in near real time.
  • CDC outpatient surveillance figure of an unprecedented 8.9 percent.
  • “Is it going to be a more severe season than last year? I think without question,” Jhung said. “Is it going to be a more severe season than a couple years ago, or the previous 10 years? We don’t know, and won’t know until the end of the season.”
  • the dominant strain so far this year is H3N2, not the novel “swine flu” strain of H1N1 that spooked the world.
  • the figure to which Google Flu Trends corresponds is the one that tells us what percentage of outpatient doctor visits are flu-related at the institutions in the CDC’s reporting network. But a separate PLOS One study from 2011 found that it doesn’t correlate quite as well with another CDC metric that’s based on the number of laboratory-confirmed cases of the flu.
mattgreatens

Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico - 0 views

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    This is one of my supplementary articles.
Casey Finnerty

Production of swine flu vaccine is way behind - Yahoo! News - 2 views

  • Also, Protein Sciences Corp. of Meriden, Conn., landed a five-year, $147 million contract to develop a vaccine using its recombinant technology — flu proteins grown in insect cells. The hope is that the first doses would be available within 12 weeks of the beginning of a pandemic. That is about twice as fast as flu vaccine produced from eggs.
Casey Finnerty

PLoS ONE: Fatal Cases of Influenza A in Childhood - 7 views

  • This work presents a rare insight into fatal influenza H3N2 in healthy children.
    • Casey Finnerty
       
      So I think we can see why some virologists were uncomfortable with keeping the swine barn open at the state fair this year!
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    Vaccinations are nice, until an antigenic strain is formed. In which case it's back to the drawing board to create a new one as soon as possible. Influenza is constantly changing in order to thrive. Amazing!
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