The main therapy of Gas Gangrene is amputation even before systemic infection, hyperbaric oxygen, or penicillin treatment therapy. Combination therapies were tested on mice with Gas Gangrene, which proved that metronidazole and penicillin together produced a higher mortality rate than that of metronidazole alone. But, metronidazole and clindamycin were more effective than penicillin alone. So some combination therapies are effective, while others are more dangerous.
Clostridial toxins are the main cause of gas gangrene. The toxins produce PLC and PFO, which lead to shock, vascular dysfunction, acute inflammatory response, and decreases endothelial cell and neutrophil function